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Bosutinib (SKI-606)

InhA, Func 380843-75-4

Produktnummer ABIN3220262

Datenblatt (PDF)

Applikation

Inhibition Assay (InhA), Functional Studies (Func)

Verwendungszweck

Bosutinib is a Bcr-Abl kinase inhibitor for the treatment of Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML). Compared to other tyrosine kinase inhibitors, it has a more favourable hematologic toxicity profile. FDA approved on September 4, 2012.

Produktmerkmale

Tradename: Bosutinib
Source of Compound: synthetic
Target: MAPK inhibitor,Src inhibitor,Bcr-Abl inhibitor,CaMK inhibitor,CDK inhibitor
Receptor: MAPKK2, MAPKKK2,ABL1, Lyn, HCK, Src,Breakpoint cluster region protein(BCR),Bcr-Abl ,CaMK,CDK 2

Aufreinigung

All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.

Reinheit

99 %

Formel

C26H29Cl2N5O3

Löslichkeit

Soluble in DMSO
Geldanamycin
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Radicicol
Inh 12772-57-5

Geldanamycin- FITC
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Nicotinamide
Inh 98-92-0 Pyridine-3-carboxylic acid amide

5-Azacytidine
Inh Cell-permeable 320-67-2 4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one

Panobinostat
Inh 404950-80-7 (E)-N-Hydroxy-3-(4-((2-(2-methyl-1H-indol-3-yl)ethylamino)methyl)phenyl)acrylamide

HPA (Hexyl-4-pentynoic acid)
Inh Cell-permeable 96017-59-3 2-(2-Propynyl)octanoic acid (racemic)

EX-527
Inh Cell-permeable 49843-98-3 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-xarboxamide (racemic)

Daminozide
Inh 1596-84-5 1-(2,2-Dimethylhydrazide)butanedioic acid

Mithramycin A
Inh 18378-89-7

Applikationshinweise

Optimal working dilution should be determined by the investigator.

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Solid

Lagerung

-20 °C

Informationen zur Lagerung

For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
Several freeze/thaw cycles should not damage the activity of our small molecule products.
However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.

Haltbarkeit

24 months
Hintergrund

Cell cycle/Checkpoint,MAPK Signaling,Neuroscience,Tyrosine Kinase/Adaptors

Molekulargewicht

530.45 g/mol

CAS-Nummer

380843-75-4