Applikation: Inhibition Assay (InhA), Functional Studies (Func)
Verwendungszweck: Montelukast is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. It is usually administered orally. Montelukast blocks the action of leukotriene D4 on the cysteinyl leukotriene receptor CysLT1 in the lungs and bronchial tubes by binding to it. This reduces the bronchoconstriction otherwise caused by the leukotriene, and results in less inflammation. Because of its method of operation, it is not useful for the treatment of acute asthma attacks. Again because of its very specific locus of operation, it does not interact with other allergy medications such as theophylline. Montelukast is marketed in United States and many other countries by Merck & Co. with the brand name Singulair®. It is available as oral tablets, chewable tablets, and oral granules. In India and other countries, it is also marketed under the brand name Montair®, produced by Indian company Cipla.
Produktmerkmale: Tradename: SINGULAIR
Source of Compound: synthetic, MK-476
Target: CysLTR antagonist
Receptor: ALOX5,CysLTR1
Aufreinigung: All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.
Reinheit: 98 %
Formel: C35H36ClNO3S
Löslichkeit: sparingly soluble in water

Geldanamycin

Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Radicicol

Inh 12772-57-5

Geldanamycin- FITC

Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Nicotinamide

Inh 98-92-0 Pyridine-3-carboxylic acid amide

5-Azacytidine

Inh Cell-permeable 320-67-2 4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one

Panobinostat

Inh 404950-80-7 (E)-N-Hydroxy-3-(4-((2-(2-methyl-1H-indol-3-yl)ethylamino)methyl)phenyl)acrylamide

HPA (Hexyl-4-pentynoic acid)

Inh Cell-permeable 96017-59-3 2-(2-Propynyl)octanoic acid (racemic)

EX-527

Inh Cell-permeable 49843-98-3 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-xarboxamide (racemic)

Daminozide

Inh 1596-84-5 1-(2,2-Dimethylhydrazide)butanedioic acid

Mithramycin A

Inh 18378-89-7

Applikationshinweise: Optimal working dilution should be determined by the investigator.
Beschränkungen: Nur für Forschungszwecke einsetzbar

Format: Solid
Lagerung: -20 °C
Informationen zur Lagerung: For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
Several freeze/thaw cycles should not damage the activity of our small molecule products.
However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.
Haltbarkeit: 24 months

Hintergrund: Immunology/Inflammation
Molekulargewicht: 586.18 g/mol
CAS-Nummer: 158966-92-8

Montelukast

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