Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

MLN8237(Alisertib)

InhA, Func 1028486-01-2
Produktnummer ABIN3219868
  • Applikation
    Inhibition Assay (InhA), Functional Studies (Func)
    Verwendungszweck
    Alisertib is a second-generation, orally bioavailable, highly selective small molecule inhibitor of the serine/threonine protein kinase Aurora A kinase with potential antineoplastic activity. Alisertib binds to and inhibits Aurora A kinase, which may result in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregation, and inhibition of cell proliferation. Aurora A kinase localizes to the spindle poles and to spindle microtubules during mitosis, and is thought to regulate spindle assembly. Aberrant expression of Aurora kinases occurs in a wide variety of cancers, including colon and breast cancers.
    Produktmerkmale
    Tradename: Alisertib
    Target: Aurora Kinase inhibitor
    Receptor: Aurora A, Aurora B
    Aufreinigung
    All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.
    Reinheit
    97 % +
    Formel
    C27H20ClFN4O4
    Löslichkeit
    Soluble in DMSO
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Solid
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
    Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
    Several freeze/thaw cycles should not damage the activity of our small molecule products.
    However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.
    Haltbarkeit
    24 months
  • Hintergrund
    Cell Cycle/Checkpoint
    Molekulargewicht
    518.92 g/mol
    CAS-Nummer
    1028486-01-2
Sie sind hier:
Kundenservice