Dacomitinib (PF299804, PF299)

Details zu Produkt Nr. ABIN3220489
Inhibition Assay (InhA), Functional Studies (Func)
Verwendungszweck Dacomitinib(PF299804, PF-00299804) is a potent, orally available, irreversible tyrosine kinase HER 1 (EGFR), HER2 and HER4 inhibitor with IC50 of 6, 45.7 and 73.7 nM for EGFR, ERBB2 and ERBB4, respectively.
Produktmerkmale Target: EGFR inhibitor, HER2 inhibitor
Receptor: EGFR/ErbB2/ErbB4
Reinigung All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.
Reinheit 97 % +
Formel C24H25ClFN5O2
Löslichkeit DMSO > 10 mM
Hintergrund JAK/STAT Signaling,Tyrosine Kinase/Adaptors
Molekulargewicht 469.94 g/mol
CAS-Nummer 1110813-31-4
Applikations-hinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Solid
Lagerung -20 °C
Informationen zur Lagerung For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
Several freeze/thaw cycles should not damage the activity of our small molecule products.
However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.
Haltbarkeit 24 months