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Trichostatin A

Inh 58880-19-6 (2E,4E,6R)-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide

Produktnummer ABIN1027849

Datenblatt (PDF)

Applikation

Inhibition (Inh)

Verwendungszweck

HDAC inhibitor

Produktmerkmale

Histone deacetylase inhibitor.

Reinheit

>98 %

Chemical Name

(2E,4E,6R)-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide

Formel

C17H22N2O3

Löslichkeit

Soluble to 10 mM in ethanol and to 50 mM in DMSO
Geldanamycin
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Radicicol
Inh 12772-57-5

Geldanamycin- FITC
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Nicotinamide
Inh 98-92-0 Pyridine-3-carboxylic acid amide

5-Azacytidine
Inh Cell-permeable 320-67-2 4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one

Panobinostat
Inh 404950-80-7 (E)-N-Hydroxy-3-(4-((2-(2-methyl-1H-indol-3-yl)ethylamino)methyl)phenyl)acrylamide

HPA (Hexyl-4-pentynoic acid)
Inh Cell-permeable 96017-59-3 2-(2-Propynyl)octanoic acid (racemic)

EX-527
Inh Cell-permeable 49843-98-3 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-xarboxamide (racemic)

Daminozide
Inh 1596-84-5 1-(2,2-Dimethylhydrazide)butanedioic acid

Mithramycin A
Inh 18378-89-7

Kommentare

Source: Synthetic.
Appearance: Beige Solid

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Solid

Vorsichtsmaßnahmen

Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R20/21/22 - Harmful by inhilation, in contact with skin and if swallowed R68 - Possible risk of irreversible effects Hazard Phrases: H302-H312-H315-H317-H319-H332-H335 Precautionary Phrases: P261-P280-P305 + P351 + P338

Handhabung

Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R20/21/22 - Harmful by inhilation, in contact with skin and if swallowed R68 - Possible risk of irreversible effects Hazard Phrases: H302-H312-H315-H317-H319-H332-H335 Precautionary Phrases: P261-P280-P305 + P351 + P338

Lagerung

-20 °C
Hintergrund

Trichostatin A is an antifungal and selectively inhibits the class I and II mammalian histon deacetlyase families of enzymes. TSA inhibits the eukayotic cell cycle during the beginning of the growth stage. It can be used to alter gene expression but interfering with the removal of acetyl groups thereby altering the ability of DNA transcription factors to access the DNA inside chromatin. It also has anti-cancer properties

Molekulargewicht

302.37

CAS-Nummer

58880-19-6