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IL-15 Proteine

(Interleukin 15 (IL15))
The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. [provided by RefSeq, Feb 2011].

68 Treffer

IL15 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant >95 % as determined by Tris-Bis PAGE, > 95 % as determined by SEC-HPLC
Produktnummer ABIN7274953
 
IL15 Spezies: Human Wirt: Escherichia coli (E. coli) > 97 % AcA, CC Active
Produktnummer ABIN6239761
 
IL15 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Produktnummer ABIN7123549
 
IL15 Spezies: Human Wirt: Wheat germ Recombinant WB, ELISA, AA, AP
Produktnummer ABIN1307695
 
IL15 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant 90 % ELISA
Pubmed 4 Referenzen
Produktnummer ABIN1047241
 
IL15 Spezies: Maus Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Produktnummer ABIN6938879
 
IL15 Spezies: Human Wirt: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Produktnummer ABIN7013412
 
IL15 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS-PAGE. Active
Produktnummer ABIN6386427
 
IL15 Spezies: Maus Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Produktnummer ABIN6731261
 
IL15 Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Produktnummer ABIN6731260
 
IL15 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 95 % as determined by reducing SDS-PAGE.
Produktnummer ABIN7504981
 
IL15 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant >95 % (SDS-PAGE) Active
Produktnummer ABIN7566189
 
IL15 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant WB, SDS, ELISA
Produktnummer ABIN7577609
 
IL15 Spezies: Maus Wirt: Escherichia coli (E. coli) Recombinant >90 % as determined by SDS-PAGE. WB, SDS, Imm, ELISA, AcA Active
Produktnummer ABIN7607470
 
IL15 Spezies: Human Wirt: Mammalian Cells Recombinant >90 % as determined by SDS-PAGE. WB, SDS, Imm, ELISA, AcA Active
Produktnummer ABIN7607252
 
IL15 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant >95 % (SDS-PAGE)
Produktnummer ABIN7278701
 
IL15 Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % by SDS-PAGE. Active
Produktnummer ABIN7520156
 
IL15 Spezies: Human Wirt: CHO Cells Recombinant >98 % (SDS-PAGE)
Produktnummer ABIN6253292
 
IL15 Spezies: Human Wirt: CHO Cells Recombinant >98 % (SDS-PAGE) Active
Produktnummer ABIN7566192
 
IL15 Spezies: Schwein Wirt: Escherichia coli (E. coli) Recombinant > 90 % WB, SDS, Imm, PC
Produktnummer ABIN7387589
 
  • Typ Protein
    • Protein
  • Anwendung
    • SDS-PAGE (SDS)
    • Western Blotting (WB)
    • ELISA
    • Immunogen (Imm)
    • Positive Control (PC)
    • Activity Assay (AcA)
    • Immunoprecipitation (IP)
    • Antibody Production (AbP)
    • Standard (STD)
    • Affinity Purification (AP)
    • Antibody Array (AA)
    • Cell Culture (CC)
    • Functional Studies (Func)
    • Immunofluorescence (IF)
    • Protein Interaction (PI)
  • Reaktivität
    • Human
    • Mouse
    • Pig
    • Rat
    • Cow
    • Rabbit
    • Sheep
    • Chicken
    • Goat
    • Guinea Pig
    • Rhesus Monkey
    • Zebrafish (Danio rerio)
    • Buffalo
    • Cat
    • Cynomolgus
    • Green Monkey
    • Panda
  • In Publikationen zitiert
  • Abbildungen verfügbar
  • Preservative free only
  • Carrier free only
  • Wirt
    • Escherichia coli (E. coli)
    • Yeast
    • HEK-293 Cells
    • CHO Cells
    • Mammalian Cells
    • Wheat germ
  • Bindungsspezifität
    • AA 49-162
    • AA 50-162
    • Q149D
    • Q156D
    • AA 1-141
    • AA 1-162
    • AA 27-161
    • AA 48-162
    • AA 67-187
    • Transcript Variant 1
    • Transcript Variant 3
    • full length
  • Konjugat
    • His tag
    • Unkonjugiert
    • Fc Tag
    • Fc Tag,AVI tag,Biotin
    • Fc Tag,Biotin
    • Fc Tag,His tag
    • GST tag
    • His-Avi Tag,Biotin
    • His-IF2DI Tag
    • Myc-DYKDDDDK Tag
  • Protein-Typ
    • Recombinant
  • Format
    • Lyophilized
    • Liquid
  • Biologische Aktivität
    • Biologically Active
  • Grade
    • Premium grade
  • Hersteller
    • antibodies-online
    • CUSABIO
    • ACROBiosystems
    • Abbexa
    • ITSI-Biosciences
    • OriGene
    • Rockland
    • BioLegend
    • Cloud-Clone
    • ProSci
    • Signalway

Aktuelle Publikationen für unsere IL-15 Proteine

Stone, Chervin, Schreiber, Kranz: "Design and characterization of a protein superagonist of IL-15 fused with IL-15R? and a high-affinity T cell receptor." in: Biotechnology progress, Vol. 28, Issue 6, pp. 1588-97, (2012) (PubMed).

Tagaya, Kurys, Thies, Losi, Azimi, Hanover, Bamford, Waldmann: "Generation of secretable and nonsecretable interleukin 15 isoforms through alternate usage of signal peptides." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 26, pp. 14444-9, (1998) (PubMed).

Krause, Jandrig, Wernicke, Bulfone-Paus, Pohl, Diamantstein: "Genomic structure and chromosomal localization of the human interleukin 15 gene (IL-15)." in: Cytokine, Vol. 8, Issue 9, pp. 667-74, (1997) (PubMed).

Meazza, Verdiani, Biassoni, Coppolecchia, Gaggero, Orengo, Colombo, Azzarone, Ferrini: "Identification of a novel interleukin-15 (IL-15) transcript isoform generated by alternative splicing in human small cell lung cancer cell lines." in: Oncogene, Vol. 12, Issue 10, pp. 2187-92, (1996) (PubMed).

Grabstein, Eisenman, Shanebeck, Rauch, Srinivasan, Fung, Beers, Richardson, Schoenborn, Ahdieh: "Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor." in: Science (New York, N.Y.), Vol. 264, Issue 5161, pp. 965-8, (1994) (PubMed).

Aliase für IL-15 Proteine

interleukin 15 (IL15) Proteine
interleukin 15 (Il15) Proteine
AI503618 Proteine
IL-15 Proteine
IL15 Proteine
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