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Results show that VGF is epigenetically modified in human non-small-cell lung cancer (NSCLC) tissues if compared to tumor-free lung tissues, which results in an increased transcription and protein expression.
results suggest VGF enhances dendritic maturation and that these effects can be altered by common SNPs in the VGF gene
We conclude that some of the already identified variants in VGF from human polymorphism studies may contribute to eating disorders and obesity.
Data show although no any significant differences between patient groups and lean subjects of proteins SYT4, BAG3, APOA1, and VAV3, except for VGF protein, there was a trend between the expression of these four genes and their protein levels.
Data show that two VGF peptides (NAPP-19 and QQET-30) were identified in plasma.
Data indicate an increased number of neurosecretory protein VGF-expressing T cells in patients with Alzheimer's disease (AD) compared to aged healthy controls.
Results indicate that neuron-restrictive silencer factor plays an important role as a repressor of VGF gene regulation in neuroblastoma cells through a mechanism that is dependent on VGF-neuron-restrictive silencer element
NERPs may be potent endogenous suppressors of glucose-dependent insulin secretion.
DISC1 knockdown leads to a reduction of VGF in neurons.
Knock-in mice expressing human VGF were fertile, had increased body weight, whereas those with c-terminal region deletion had reduced adiposity, increased energy expenditure, and improved glucose tolerance.
We conclude that VGF contributes to survival and function of peripheral T cells
Among the 19 genes tested, VGF was found to be completely methylated in several Urothelial Cell Carcinoma cell lines
results indicate that VGF and PGP9.5 PH are potential biomarkers for ovarian carcinoma
The expression of NPY and VGF was increased in the arcuate nucleus, but decreased in the nucleus of the Tractus Solitarius in the brains of type-II diabetic patients.
[review] The vgf gene is induced in vivo by neurotrophins including nerve growth factor (NGF), brain derived growth factor (BDNF) and glial derived growth actor (GDNF), by synaptic activity and by homeostatic and other stimuli.
VGF is regulated by SOD1 and plays a critical role in motor neuron survival
localization of neuroendocrine regulatory peptide-1 and-2 (NERP-1 and NERP-2); results suggest that neuroendocrine NERP-1 and NERP-2 might function as local modulatorsin the neuroendocrine system
VGF is downregulated in bipolar disorder in the CA region of the hippocampus and Brodmann's area 9 of the prefrontal cortex.
VGF mRNA levels were significantly reduced in drug-free depressed patients, as compared with controls, and were modulated in response to effective antidepressant treatment.
Application of neurosecretory protein VGF biomarker model to current diagnostic criteria provides an objective biomarker pattern that identifies patients with amyotrophic lateral sclerosis.
Study demonstrates that VGF-overexpressing mice exhibit behavioral and morphological abnormalities that may be related to the mental illnesses such as schizophrenia and depression. These findings indicate that VGF may be implicated in the pathogenesis of several mental illnesses and in brain development.
Upregulation of VGF may be implicated in the pathophysiology of schizophrenia.
conclude that the metabolic profile of germline VGF knockout mice is largely the result of VGF ablation in embryonic CNS neurons
VGF neuropeptides promote oligodendrogenesis in vitro, whereas Snf2h cKO mice treated with full-length VGF-encoding adenoviruses removed the requirement of exercise for survival.
These observed changes in energy expenditure and food intake were associated with an increase in the hypothalamic contents of the VGF-derived peptides AQEE, TLQP and NERP-2. The complex phenotype of the VGF-/- mice is a likely consequence of global ablation of the gene and its derived peptides during development, as well as in the adult.
GnRH stimulated the secretion of the VGF-derived peptide NERP1. NERP1 caused a concentration-dependent decrease in Fshb gene induction.
results suggest hypothalamic VGF responds to environmental demands and plays an important role in energy balance and glycemic control likely acting in the melanocortin pathway downstream of BDNF.
Data indicate that high-fat diet induced obese mice showed reduced plasma VGF C-terminus, NAPPE and QQET-like (ERVW) peptide.
VGF expression is regulated by DISC1 through the activation of the PI3K/AKT/CREB pathway.
This study found that VGF expression, both mRNA and protein, was increased 1 h after training in the dorsal hippocampus.
Derived from the C-terminus of VGF, endogenous TLQP-21 peptide contributes to the mechanisms of spinal neuroplasticity after inflammation and nerve injury.
VGF has a role in adrenal large dense core vesicle formation and the regulation of catecholamine levels and blood pressure
These findings reveal that NERP-2 regulates glucose-stimulated insulin secretion by elevating intracellular calcium concentrations.
We propose that VGF and/or VGF-derived peptides modulate sympathetic outflow pathways to regulate fat storage and energy expenditure.
Modulation of VGF levels and/or VGF signaling may consequently represent an alternative means to regulate circulating glucose levels and insulin sensitivity.
VGF may act downstream of brain-derived neurotrophic factor and exert antidepressive effects by enhancing neurogenesis in the hippocampus.
the exercise-regulated gene VGF has an antidepressant effect
while Vgf may be a reliable biomarker of progression of muscle weakness in patients with ALS, restoration of Vgf expression in spinal cord motor neurons may therapeutically rescue spinal cord motorneurons against excitotoxic injury
This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known.
VGF nerve growth factor inducible
, Neurosecretory protein VGF
, neuro-endocrine specific protein VGF
, neurosecretory protein VGF
, VGF8a protein