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Human Polyclonal O3FAR1 Primary Antibody für ICC, IF - ABIN314627
Liu, Chen, Sokolowska, Eberlein, Alsaaty, Martinez-Anton, Logun, Qi, Shelhamer: The fish oil ingredient, docosahexaenoic acid, activates cytosolic phospholipase A₂ via GPR120 receptor to produce prostaglandin E₂ and plays an anti-inflammatory role in macrophages. in Immunology 2014
Show all 16 Pubmed References
Human Monoclonal O3FAR1 Primary Antibody für FACS, IF - ABIN533489
Gotoh, Hong, Iga, Hishikawa, Suzuki, Song, Choi, Adachi, Hirasawa, Tsujimoto, Sasaki, Roh: The regulation of adipogenesis through GPR120. in Biochemical and biophysical research communications 2007
Show all 4 Pubmed References
Human Polyclonal O3FAR1 Primary Antibody für IHC (p) - ABIN270758
Milton, Khaire, Ingram, ODonnell, La Thangue: 14-3-3 proteins integrate E2F activity with the DNA damage response. in The EMBO journal 2006
Human Polyclonal O3FAR1 Primary Antibody für IF (p), IHC (p) - ABIN1387736
Meng, Yuan, Zhang, Zhang, Fu, Zhu, Shu, Wang, Gao, Xi, Sun, Zhang, Jiang, Wang: Stearic acid suppresses mammary gland development by inhibiting PI3K/Akt signaling pathway through GPR120 in pubertal mice. in Biochemical and biophysical research communications 2017
Human Polyclonal O3FAR1 Primary Antibody für IHC (p) - ABIN4311410
Li, Kokrashvili, Mosinger, Margolskee: Gustducin couples fatty acid receptors to GLP-1 release in colon. in American journal of physiology. Endocrinology and metabolism 2013
we established that GPR120 functions as a chemoresistance-promoting receptor in breast cancer. The activation of GPR120 signaling using its ligands in breast cancer cells promoted the resistance against epirubicin-induced cell death by increasing ABC transporter expression and de novo fatty acid synthesis.
Results show that downregulation of GPR120 in decidua was correlated with human miscarriage suggesting that GPR120 plays protective role in the maintenance of pregnancy by promoting decidualization during early pregnancy. Moreover, the augmentation of decidualization by GPR120 was mediated by improved glucose influx and metabolism of human endometrial stromal cells.
FFA1 and FFA4 are involved in the regulation of cellular functions during tumor progression in colon cancer DLD1 cells.
GPR120 mediates docosahexaenoic acid-induced apoptosis by regulating IP3R, reactive oxygen species, and endoplasmic reticulum stress levels in cisplatin-resistant cancer cells
Our study suggests that GPR120 is an important inflammatory mediator during the development of osteoarthritis
these findings define a mechanism by which FFAR1-and FFAR4-dependent activation of Hippo pathway mediates DHA-induced apoptosis of androgen-independent prostate cancer cells.
FFAR4 overexpression may mediate the process of cholangiocarcinoma (CCA) epithelial mesenchymal transition. In addition, FFAR4 is promising as a new diagnostic molecule and therapeutic target for CCA.
Results indicate that FFAR4 plays a more critical role than FFAR1 in mediation of fat-regulated neurotensin release from neuroendocrine cells and in inhibitory crosstalk between MEK/ERK1/2 and AMPK in the control of NT release downstream of FFAR1 and FFAR4.
Compared with nevi, primary melanoma and melanoma metastasis showed significantly higher levels of GPR120 staining.
An increased level of GPR120 in esophageal cancer tissues.
Data suggest that cytokines TNFalpha and interleukin-1b markedly reduce GPR120/FFAR4 expression in adipocytes; in contrast, these cytokines induce expression of GPR84 and GPR41/FFAR3 in adipocytes. These studies were conducted in adipocytes cultured from subcutaneous adipose tissue. (GPR = G-protein coupled receptor; FFAR = free fatty acid receptor)
Fatty acids are capable of directly acting on visceral adipocytes to modulate differently TNF-alpha, IL-6, IL-10 and adiponectin expression, with a different and greater effect in morbidly obese subjects. These effects are largely annulled when GPR120 expression was silenced, which suggests that they could be mediated by GPR120.
The results of this study suggest that n-3 PUFA protect hepatic steatosis by activating FFA4 in hepatocytes, and its signaling cascade sequentially involves FFA4, Gq/11 proteins, CaMKK, AMPK, and SREBP-1c suppression.
Studied action of linoleic acid (LA) on cell migration and neoplasm invasiveness of breast cancer cells. Findings show Akt2 activation requires EGFR and PI3K activity, whereas migration and invasion are dependent on FFAR4, EGFR and PI3K/Akt activity.
Eicosapentaenoic acid prevents TNF-alpha-induced decrease of alpha-methylglucose uptake and AMPK phosphorylation in Caco-2 cells via GPR120 and AMPK activation.
P.R270H of FFAR4 impairs Gq and Gi signalling of FFAR4 in vitro.
G protein-coupled receptor 120 (GPR120) represents a promising target for the treatment of obesity-related metabolic disorders for its involvement in the regulation of adipogenesis, inflammation, glucose uptake, and insulin resistance. This review summarizes recent studies and advances regarding the systemic role of GPR120 in adipose tissue, including both white and brown adipocytes. [review]
p.R270H variant of GPR120 modulates the risk of type 2 diabetes in interaction with dietary fat intake.
These results indicated that GPR120 enhanced and GPR40 inhibited the cell motile activity of highly migratory osteosarcoma cells.
LPA1 plays a critical role in EGF responses and that FFA4 agonists inhibit proliferation by suppressing positive cross-talk between LPA1 and the EGF receptor
browning of adipocyte was induced by 9-PAHSA through activating GPR120 and inhibiting the LPS/NF-kappaB pathway.
FFAR4 is differentially expressed and correlated to cytokine expressions in peritoneal macrophages and alveolar macrophages from BALB/c mice.
Ovarian hormones may directly regulate GPR120 expression in the reproductive cycle at the pituitary level.
this is the first animal study to provide evidence that FFA4 may mediate the protective roles of n-3 fatty acids on lean mass percentage as well as fat mass percentage.
Data suggest that omega-3 fatty acids, common dietary lipids, participate in immunomodulation; here, EPA (eicosapentaenoic acid) activates macrophage RAW264.7 cells through GPR120-mediated Raf-ERK1/2-IKKbeta-NFkappaB p65 signaling pathways.
GPR120 suppresses adipose tissue lipolysis and synergizes with GPR40 in antidiabetic efficacy
Docosahexaenoic acid activates GPR120 to prevent experimental colitis in IL-10 deficient mice.
GPR120 (and GPR40) act in concert in the hypothalamus to reduce energy efficiency and regulate the inflammation associated with obesity.
Acute reductions in food intake and food reward suggest that GPR120 could mediate the effects of central omega-3 polyunsaturated fatty acids to inhibit appetite.
These data reveal important structure-function and signaling differences between the two FFA4 isoforms, and for the first time link FFA4 to modulation of ROS in macrophages.
Results provide evidence that GPR120 promotes adipogenesis by increasing PPARgamma expression via [Ca(2+)]i and ERK1/2 signal pathway in 3T3-L1 adipocytes.
GPR120-induced incretin glucse-dependent insulinotropic polypeptide secretion is indirectly mediated by cholecystokinin.
Leukocyte GPR120/FFAR4 WT or KO mice in the LDL receptor KO background were generated by bone marrow transplantation.leukocyte GPR120 expression has minimal effects on dietary PUFA-induced plasma lipid/lipoprotein reduction and atheroprotection, and there is no distinction between n-3 versus n-6 PUFAs in activating anti-inflammatory effects of leukocyte GPR120/FFAR4 in vivo
Collectively, these findings showed that SA suppressed mammary gland development of pubertal mice, which was coincident with the SA-inhibited HC11 proliferation, and was associated with inhibition of PI3K/Akt signaling pathway through activation of GPR120.
omega-3 fatty acids-induced proliferation of bronchiole epithelial cells through FFA4 is responsible for Omacor-induced accelerated recovery from airway injury.
GPR120 silencing in adipocytes inhibited the expression of PPARgamma and miR-143, whereas GPR120 overexpression led to increased expressions of PPARgamma and miR-143.
GPR120 expression in beta-cells and GPR120-mediated insulinotropic effects are altered in obesity and diabetic states in distinct ways, and these alterations may be mediated by PPARgamma.
Data show that agonizing G protein-coupled receptor 120 (GPR120) differentially regulates the pro-inflammatory adipocytokines.
determination of the presence of FFA4 receptor in bovine neutrophils
GPR120 is highly expressed in porcine mature adipose tissue and is positively associated with adipose tissue development. 5 CpG islands across GPR120 gene exhibit different methylation states. DNA methylation of GPR120 5'-untranslated and first exon regions can negatively regulate its expression levels.
C/EBP-beta plays a vital role in regulating GPR120 transcription.
This gene encodes a G protein-coupled receptor (GPR) which belongs to the rhodopsin family of GPRs. The encoded protein functions as a receptor for free fatty acids, including omega-3, and participates in suppressing anti-inflammatory responses and insulin sensitizing. Multiple transcript variants encoding different isoforms have been found for this gene.
G-protein coupled receptor 120
, G-protein coupled receptor 129
, G-protein coupled receptor GT01
, G-protein coupled receptor PGR4
, omega-3 fatty acid receptor 1
, G protein-coupled receptor 120
, G-protein-coupled receptor GT01