anti-V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A (Avian) (MAFA) Antikörper

Mouse (Murine) V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A (Avian) (MAFA) Interaktionspartner

1. Data suggest that hepatocytes can be reprogrammed into insulin (zeige INS Antikörper)-producing cells in vivo by transfection of neurogenin-3 (zeige NEUROG3 Antikörper), Pdx1 (zeige PDX1 Antikörper), and MafA genes using non-viral hydrodynamics injection; this procedure was used in treatment of streptozotocin diabetes; fasting blood glucose was reduced to normal. (Pdx1 (zeige PDX1 Antikörper) = pancreatic and duodenal homeobox 1 (zeige PDX1 Antikörper); MafA = v-maf (zeige MAF Antikörper) musculoaponeurotic fibrosarcoma oncogene (zeige RAB1A Antikörper) family, protein A (zeige GPR153 Antikörper))

2. Mafa was found to both potentiate the ability of Pdx1 (zeige PDX1 Antikörper) to induce beta-cell formation from Ngn3 (zeige NEUROG3 Antikörper)-positive endocrine precursors and enable Pdx1 (zeige PDX1 Antikörper) to produce beta-cells from alpha-cells.

3. MAFA controls autonomic nervous system-mediated insulin secretion by activating the transcription of nicotinic (ChrnB2 and ChrnB4) receptor genes, which is impaired in type 2 diabetes.

4. These findings demonstrate that regulation of monoamine levels by Mao (zeige MAO Antikörper) activity in beta cells is pivotal for physiological insulin (zeige INS Antikörper) secretion and that loss of MaoB (zeige MAOB Antikörper) expression may contribute to the beta cell dysfunction in type 2 diabetes.

5. is necessary for the maintenance of normal insulin (zeige INS Antikörper) levels even in embryos.

6. endogenous small-Maf (zeige MAF Antikörper) factors negatively regulate beta-cell function by competing for MafA binding, and thus, the inhibition of small-Maf (zeige MAF Antikörper) activity can improve beta-cell function

7. Data, including data from studies using transgenic/knockout mice, confirm the expression of Mafa and Mafb (zeige MAFB Antikörper) is specific to insulin (zeige INS Antikörper)-secreting cells of the pancreas.

8. These results suggest that MafA regulates the postnatal proliferation of beta-cells via prolactin (zeige PRL Antikörper) signaling.

9. results illustrate how consequential the reduction in Mafa activity is to islet beta-cell function under pathophysiological conditions.

10. Results not only clearly define why MafA is an essential transcriptional regulator of islet beta-cells, but also why cell maturation involves coordinated actions with MafB (zeige MAFB Antikörper).

Human V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A (Avian) (MAFA) Interaktionspartner

1. Pdx1 (zeige PDX1 Antikörper) and MafA (zeige KLRG1 Antikörper) play crucial roles in the pancreas and maintain mature beta-cell function. Our results showed that the expression of Pdx1 (zeige PDX1 Antikörper) and MafA (zeige KLRG1 Antikörper) were significantly upregulated after a sleeve gastrectomy for morbid obesity.

2. MAFA controls autonomic nervous system-mediated insulin secretion by activating the transcription of nicotinic (ChrnB2 and ChrnB4) receptor genes, which is impaired in patients with type 2 diabetes.

3. These findings demonstrate that regulation of monoamine levels by Mao (zeige MAO Antikörper) activity in beta cells is pivotal for physiological insulin (zeige INS Antikörper) secretion and that loss of MaoB (zeige MAOB Antikörper) expression may contribute to the beta cell dysfunction in type 2 diabetes.

4. MAFA (zeige KLRG1 Antikörper), MAFB (zeige MAFB Antikörper), NKX6.1 (zeige NKX6-1 Antikörper), and PDX1 (zeige PDX1 Antikörper) activity provides a gauge of islet beta cell function, with loss of MAFA (zeige KLRG1 Antikörper) (and/or MAFB (zeige MAFB Antikörper)) representing an early indicator of beta cell inactivity

5. Loss of MAFA (zeige KLRG1 Antikörper) expression is associated with insulinoma (zeige RPS15 Antikörper).

6. MAFA (zeige KLRG1 Antikörper) nuclear expression in pancreatic alpha and beta cells, and the percentage of alpha cells expressing PAX4 (zeige PAX4 Antikörper) are altered in patients with type 2 diabetes.

7. under oxidative and nonoxidative conditions p38 MAPK (zeige MAPK14 Antikörper) directly binds to MafA (zeige KLRG1 Antikörper) and triggers MafA (zeige KLRG1 Antikörper) degradation via ubiquitin proteasomal pathway.

8. Beta cell nuclear MafA (zeige KLRG1 Antikörper) is markedly decreased in humans with type 2 diabetes, which may contribute to impaired beta cell dysfunction.

9. Combined transfection of the three transcriptional factors, PDX-1 (zeige PDX1 Antikörper), NeuroD1 (zeige NEUROD1 Antikörper), and MafA (zeige KLRG1 Antikörper), causes differentiation of bone marrow mesenchymal stem cells into insulin (zeige INS Antikörper)-producing cells

10. Data suggest that MafA (zeige KLRG1 Antikörper) plays a novel role in the reprogramming of stem cells into pancreatic beta-progenitors, promotes the islet-like characteristics of PDMSCs, as well as functionally regulation of blood glucose levels in transplanted grafts.

Pig (Porcine) V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A (Avian) (MAFA) Interaktionspartner

1. Report pancreatic expression of MafA in pancreas.