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anti-Human DIO2 Antikörper:
anti-Mouse (Murine) DIO2 Antikörper:
anti-Rat (Rattus) DIO2 Antikörper:
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Mouse (Murine) Polyclonal DIO2 Primary Antibody für ELISA, IHC - ABIN314280
Langford, Baron, Joy, Del Valle, Shack: Contributions of HIV infection in the hypothalamus and substance abuse/use to HPT dysregulation. in Psychoneuroendocrinology 2011
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Mouse (Murine) Polyclonal DIO2 Primary Antibody für IHC, ELISA - ABIN190862
Gumieniak, Perlstein, Williams, Hopkins, Brown, Raby, Williams: Ala92 type 2 deiodinase allele increases risk for the development of hypertension. in Hypertension 2007
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The Thr92Ala polymorphism of D2 was not associated with thyroid parameters, HRQoL, and cognitive functioning in the general population and in participants on thyroid hormone (zeige PTH Antikörper) replacement therapy.
Thyroidectomized patients carrying DIO2 Thr92Ala are at increased risk of reduced intracellular and serum T3 concentrations that are not adequately compensated for by LT4, thus providing evidence in favor of customized treatment of hypothyroidism in athyreotic patients.
D2-Thr92Ala genetic variant is associated with the severity and the obstetric outcome of preeclampsia, and it also influences thyroid hormone (zeige PTH Antikörper) levels.
Homozygosity for the Dio2 Thr92Ala polymorphism is associated with higher HbA1C levels in type 2 diabetes patients. [Meta-Analysis]
the reduction of SAT DIO2 expression is negatively correlated with DBP (zeige GC Antikörper) and TG levels that are associated with the MetS (zeige ETV3 Antikörper). This might have an effect on developing MetS (zeige ETV3 Antikörper).
In subjects who are alcohol dependent, the rs225014 DIO2 gene was associated with significant differences in the amount of naturalistic alcohol drinking.
Data provide evidence in humans that genetic predisposition combined with early osteoarthritis-related changes results in loff of epigenetic silencing of DIO2.
DIO2 gene plays a role in the etiology of recurrent depressive disorder.Association of the DIO2 gene single nucleotide polymorphisms with recurrent depressive disorder.
DIO2 gene polymorphisms may play a role in the incidence of MCI (zeige MCIN Antikörper) in male patients.
conversion of T4 to T3 by D2 is required for TRalpha1/PI3K (zeige PIK3CA Antikörper)-mediated nongenomic actions of T4 in HUVECs, including stimulation of Akt (zeige AKT1 Antikörper) phosphorylation and Rac (zeige AKT1 Antikörper) activation, which result in cell migration.
Results indicate that basal cell carcinoma cells constitute an example in which the thyroid hormone (zeige PTH Antikörper) signal is finely tuned by the concerted expression of opposite-acting deiodinases. The dual regulation of Dio2 and Dio3 (zeige DIO3 Antikörper) expression plays a critical role in cell cycle progression and cell death by influencing cyclin D1 (zeige CCND1 Antikörper)-mediated entry into the G1-S phase.
Two mouse models of early developmental disruption of Dio2 in myocyte precursor exhibit no significant skeletal muscle phenotype.
Dio3 (zeige DIO3 Antikörper)-/- mice display degeneration of retinal cones, the photoreceptors that mediate daylight and color vision. In Dio2-/- mice, cone function was largely normal but deletion of Dio2 in Dio3 (zeige DIO3 Antikörper)-/- mice markedly recovered cone numbers and electroretinogram responses, suggesting counterbalancing roles for both enzymes in cone survival.
The consistent association between Calr (zeige CALR Antikörper) and Dio2 expression suggests that enhanced expression of these two genes facilitate detrimental effects on cartilage integrity.
mice with astrocyte-specific Dio2 inactivation (Astro-D2KO) have normal serum T3 but exhibit anxiety-depression-like behavior as found in open field and elevated plus maze studies and when tested for depression using the tail-suspension and the forced-swimming tests
Mice subjected to a running regime have significant increased cartilage damage and synovitis scores. Lack of Dio2 protected against cartilage damage in this model and was reflected in a specific gene expression profile.
Data show that type 2 deiodinase (Dio2) inactivation in skeletal myocytes preserves T3 thyroid hormone (zeige PTH Antikörper) content and only mildly disrupts thyroid hormone (zeige PTH Antikörper) signaling.
These studies reveal that tissue-specific differences in D2 ubiquitination are an inherent property of the TRH/TSH feedback mechanism
congenital severe reduction of thyrotroph Dio2 causes a major impairment of the TSH response to hypothyroidism
Systemic changes in thyroid hormone (zeige PTH Antikörper) economy as a result of acute food deprivation are not dependent on the deiodinases D1 or D2 but are mediated in part by sequestration of type 4 and type 3 in tissues and their enhanced metabolism by deiodinase D3.
This study investigated deiodinase 1 (Dio1 (zeige DIO1 Antikörper)), deiodinase 2 (Dio2), and deiodinase 3 (Dio3 (zeige DIO3 Antikörper)) mRNA expression at the several zebrafish life stages and found life stage specific expression of these genes that were highly localized.
Increased expression of mammary TRbeta1 (zeige THRB Antikörper) and DIO2, and decreased RXRalpha (zeige RXRA Antikörper), provide a mechanism to increase thyroid hormone (zeige PTH Antikörper) activity within the mammary gland during lactation.
No changes in TRb or DI-2 and DI-3 expression in tail tissue collected from Triclosan exposure larvae were found.
The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms.
thyroxine deiodinase, type II
, type 2 DI
, type 2 iodothyronine deiodinase
, type II iodothyronine deiodinase
, type-II 5'-deiodinase
, type-II 5'deiodinase
, iodothyronine type II deiodinase
, type-II 5' deiodinase
, deiodinase, iodothyronine, type 2
, deiodinase, iodothyronine, type II
, deiodinase 2
, type 2 deiodinase