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anti-Human OAS2 Antikörper:
anti-Mouse (Murine) OAS2 Antikörper:
anti-Rat (Rattus) OAS2 Antikörper:
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Epigenetic regulation of OAS2 shows disease-specific DNA methylation (zeige HELLS Antikörper) profiles at individual CpG sites.
we characterized the functional consequences of the Neandertal haplotype in the transcriptional regulation of OAS (zeige SMOC1 Antikörper) genes at baseline and infected conditions. We found that cells from people with the Neandertal-like haplotype express lower levels of OAS3 (zeige OAS3 Antikörper) upon infection, as well as distinct isoforms of OAS1 (zeige OAS1 Antikörper) and OAS2
Suggest 2'5'-oligoadenylate synthetase 2 mediates T-cell receptor CD3-zeta (zeige CD247 Antikörper) chain down-regulation via caspase-3 (zeige CASP3 Antikörper) activation in oral cancer.
Data obtained suggest that the OAS2 rs1293762 and CD209 (zeige CD209 Antikörper) rs2287886 SNPs are associated with predisposition to chronic hepatitis C in Russian population.
Primary mononuclear cells from patients with systemic sclerosis have increased basal levels of OASL (zeige OASL Antikörper) and OAS2 genes.
The results suggest that OAS1 (zeige OAS1 Antikörper)-OAS3 (zeige OAS3 Antikörper)-OAS2 haplotypes are associated with differential susceptibility to clinical outcomes of dengue infection.
The data suggest a possible association between OAS2 and OAS3 (zeige OAS3 Antikörper) single nucleotide polymorphisms and the outcome of tick-borne encephalitis virus infection in a Russian population.
2'-5'-oligoadenylate synthetase type 2 (OAS2), a dsRNA binding protein involved in the pathway that activates RNase-L (zeige RNASEL Antikörper), is identified as a new binding partner for NOD2 (zeige NOD2 Antikörper).
A non-synonymous mutation in Oas2 (I405N) in the viral sensor Oas2 was found and the mutation caused post-partum failure of lactation in healthy mice with otherwise normally developed mammary glands, characterized by greatly reduced milk protein synthesis coupled with epithelial cell death, inhibition of proliferation and a robust interferon (zeige IFNA Antikörper) response. The mutation activates the OAS2 pathway.
Endogenous expression of the porcine OAS2 gene could be promoted by interferon (zeige IFNA Antikörper) (IFN)-beta (zeige IFNB1 Antikörper) or PRRSV infection in porcine alveolar macrophages. Knockdown of porcine OAS2 led to increases in PRRSV replication, and OAS2 expression suppressed replication of PRRSV in a retinoic acid inducible gene I (RIG-I (zeige DDX58 Antikörper))-dependent manner, anti-PRRSV activity of porcine OAS2 would be lost if RNase L (zeige RNASEL Antikörper) and OAS2 were both silenced.
This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described.
(2'-5')oligo(A) synthetase 2
, 2'-5'-oligoadenylate synthase 2
, 2-5A synthase 2
, p69 OAS / p71 OAS
, (2-5')oligo(A) synthase 2
, 2',5'-oligoadenylate synthetase-like 11
, 2'-5' oligoadenylate synthetase-like 11
, 2,5-oligoadenylate synthetase-like 11
, 2'-5'-oligoadenylate synthetase 2, 69/71kDa
, 2'-5' oligoadenylate synthetase 2
, 2',5'-oligoadenylate synthetase 2
, 2'-5'-oligoadenylate synthetase 2-like
, 2'-5'-oligoadenylate synthase 2-like