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Human Polyclonal PRKAR2A Primary Antibody für WB - ABIN519185
Uys, Ramburan, Loos, Kinnear, Korkie, Mouton, Riedemann, Moolman-Smook: Myomegalin is a novel A-kinase anchoring protein involved in the phosphorylation of cardiac myosin binding protein C. in BMC cell biology 2011
High PK-R2 (zeige PROKR2 Antikörper) expression is associated with colorectal cancer.
Prkar2a deficiency predisposes to hematopoietic malignancies in vivo. RIIalpha's likely association with HS and DLBCL was hitherto unrecognized and may lead to better understanding of these rare neoplasms.
Disruption of Snapin (zeige SNAPIN Antikörper)-PKR2 (zeige PROKR2 Antikörper) interaction did not affect PKR2 (zeige PROKR2 Antikörper) signaling, but increased the ligand-induced degradation, implying a role of Snapin (zeige SNAPIN Antikörper) in the trafficking of PKR2 (zeige PROKR2 Antikörper).
we demonstrate that neurochondrin has strong isoform selectivity towards the RIIa subunit of PKA with nanomolar affinity
Results show that mouse Prkar1a (zeige PRKAR1A Antikörper) and human PRKAR2A exhibited a dynamic spatio-temporal expression in tooth development, whereas neither human PRKAR1A (zeige PRKAR1A Antikörper) nor mouse Prkar2a showed their expression in odontogenesis.
These data demonstrate that some Kallmann syndrome-associated, intracellularly retained mutant PKR2 (zeige PROKR2 Antikörper) receptors can be functionally rescued, suggesting a potential treatment strategy for patients bearing such mutations.
while there is no change in type II regulatory (RIIalpha) or catalytic (Calpha (zeige PRKACA Antikörper)) subunit expression, site specific RIIalpha (Ser96) and Calpha (zeige PRKACA Antikörper) (Thr197) phosphorylation are increased in heart failure, as well as expression of type I regulatory subunit (RI)
Smad4 (zeige SMAD4 Antikörper) and the R subunit of the protein kinase A holoenzyme form a functional complex in vivo in response to TGFbeta (zeige TGFB1 Antikörper).
ETO nervy homology region (NHR) 3 domain-PKA(RIIalpha) protein interaction does not appear to significantly contribute to AML1-ETO's ability to induce leukemia.
These data implicate the involvement of PKA-RIIalpha anchoring apical targeting of distinct proteins and glycosphingolipids to apical plasma membrane domains and suggest that rerouting may underlie the delayed Golgi-to-apical surface transport of MDR1 (zeige TBC1D9 Antikörper).
angle X-ray scattering studies indicate RIalpha (zeige PRKAR1A Antikörper), RIIalpha, and RIIbeta (zeige PRKAR2B Antikörper) homodimers differ markedly in overall shape despite extensive sequence homology and similar molecular masses;cAMP binding does not cause large conformational changes(Prkar1a (zeige PRKAR1A Antikörper), Prkar2a)
PGD2 (zeige PTGDS Antikörper)-DP1 (zeige REEP5 Antikörper) axis-induced M2 polarization facilitates resolution of inflammation through the PRKAR2A-mediated suppression of JAK2 (zeige JAK2 Antikörper)/STAT1 (zeige STAT1 Antikörper) signaling.
Results indicte that Cypher/ZASP (zeige LDB3 Antikörper) interacted with the regulatory subunit RIIalpha of PKA.
a key role for AKAP (zeige AKAP1 Antikörper)-targeted PKA in control of heart rate and contractile function
The RII alpha regulatory subunit of protein kinase A is not required for normal T cell development, homeostasis, and the generation of a cell-mediated immune response in vivo.
The high-resolution crystal structures of the docking and dimerization (D/D) domain of the RIIalpha regulatory subunit of PKA in complex with the high-affinity anchoring peptide AKAP (zeige AKAP1 Antikörper)-IS explain the molecular basis for AKAP (zeige AKAP1 Antikörper)-regulatory subunit recognition.
crystal structure of RIIalpha holoenzyme solved and compared to the RIalpha (zeige PRKAR1A Antikörper) holoenzyme; structure demonstrates the conserved and isoform-specific features of RI and RII and the importance of ATP
AKAP121 (zeige AKAP1 Antikörper) and PKAR2A serve to enhance steroidogenesis by directing the synthesis and activation of STAR at the mitochondria in response to cAMP.
protein kinase cAMP dependent regulatory type II alpha showed a clear-cut double striation pattern on each m-line and z-line.
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER).
cAMP-dependent protein kinase regulatory subunit RII alpha
, cAMP-dependent protein kinase type II-alpha regulatory subunit
, protein kinase A, RII-alpha subunit
, cAMP-dependent protein kinase, regulatory subunit alpha 2
, protein kinase, cAMP-dependent, regulatory, type II, alpha
, carnitine/acylcarnitine translocase
, cAMP-dependent protein kinase type II-alpha regulatory subunit-like
, protein kinase cAMP-dependent regulatory type II alpha
, protein kinase, cAMP-dependent, regulatory, type 2, alpha
, LOW QUALITY PROTEIN: cAMP-dependent protein kinase type II-alpha regulatory subunit