Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Weitere Synonyme anzeigen
Wählen Sie die gewünschte Spezies
Frameshift Mutation of GLI1 is associated with Colorectal Cancer.
Histone deacetylase 6 (HDAC6 (zeige HDAC6 Proteine)) inhibition enhanced glioma stem cells (GSCs) radiosensitivity via inactivating sonic hedgehog protein (SHH (zeige SHH Proteine))/glioma-associated oncogene homolog 1 (Gli1) pathway.
HPI-1 worked more effectively than GANT-58 against breast carcinoma cells. In conclusion, HPI-1 could inhibit cell proliferation, reduce cell invasion and decrease cancer stem cell population in breast cancer cells. To target Gli-1 could be a potential strategy to suppress breast cancer stem cells.
High GLI1 expression is associated with unfavorable OS and FPS (zeige FDPS Proteine) in patients with gastric cancer. As a member of the Hedgehog (zeige SHH Proteine) signaling pathway, GLI1 co-expressed genes are also largely enriched in PI3K (zeige PIK3CA Proteine)/AKT (zeige AKT1 Proteine) pathway in gastric cancer.
the results suggest that aberrant expression of Gli1 serves a role in HSCR (zeige EDNRB Proteine) by targeting EDNRB (zeige EDNRB Proteine).
High GLI1 expression is associated with Small Cell Lung Cancer.
Abnormal elevation of Gli1 and decrease of miR (zeige MLXIP Proteine)-361 were found in esophageal cancer tissues. MiR (zeige MLXIP Proteine)-361 weakened invasion of cancer cells and impeded EMT (zeige ITK Proteine) process via the inhibition of Gli1.
Data show that miR (zeige MLXIP Proteine)-150 inhibits glioma-associated oncogene homolog 1 (Gli1) expression via targeting 3'-UTR of Gli1 gene.
Downregulation of miR (zeige MLXIP Proteine)-150 and elevation of Gli1 promote the development and invasion of colorectal cancer cell Epithelial-mesenchymal transition (EMT (zeige ITK Proteine)). MiR (zeige MLXIP Proteine)-150 attenuated the progression of colorectal cancer cell EMT (zeige ITK Proteine) via inhibiting Gli1.
data collectively suggest that silencing of PRMT1 (zeige PRMT1 Proteine) exerts anti-catabolic and anti-inflammatory effects on IL-1beta (zeige IL1B Proteine)-induced chondrocytes via suppressing the Gli-1 mediated Hedgehog (zeige SHH Proteine) signaling pathway, indicating that PRMT1 (zeige PRMT1 Proteine) plays a critical role in OA development and serves as a promising therapeutic target for OA.
Data indicate that the expression levels of transcription factors Gli1 and Gli2 in muscle were the lowest of the 13 tissues.
Dzip1 (zeige DZIP1 Proteine)-dependent stabilization of Spop/HIB is evolutionarily conserved and essential for proper regulation of Gli/Ci proteins in the Hh pathway.
Zyxin (zeige ZYX Proteine) inhibits Shh (zeige SHH Proteine) signaling during the CNS patterning in Xenopus laevis through interaction with Gli1
Mutation of hmgcs1 (zeige HMGCS1 Proteine) had no effect on Shh (zeige SHH Proteine) signaling at 2 and 3 days post fertilization (dpf), but did result in a decrease in the expression of gli1, a known Shh (zeige SHH Proteine) target gene, at 4 dpf, after morphological deficits in craniofacial development and chondrocyte differentiation were observed in hmgcs1 (zeige HMGCS1 Proteine) mutants.
a new mechanism of Gli transcription factor activation and implicate ARHGAP36 (zeige ARHGAP36 Proteine) dysregulation in the onset and/or progression of GLI-dependent cancers.
We show that Kif7 interacts with both Gli1 and Gli2a and suggest that it functions to sequester Gli proteins in the cytoplasm, in a manner analogous to the regulation of Ci by Cos2 in Drosophila.
Gli1 has a Hh-independent role in many motoneurons and V3 domain cells in embryos that lack Hh signalling, but removal of Gli1 activity does not affect more dorsal neurons.
These results reveal divergent requirements for Gli1 and Gli2 in mouse and zebrafish and indicate that zebrafish Gli1 is an activator of Hh-regulated genes, while zebrafish Gli2 has minor roles as a repressor or activator of Hh targets.
Gli1 regulates the maintenance of neural progenitors at the midbrain-hindbrain boundary in concert with E(Spl (zeige SGPL1 Proteine)) factor activity.
Zinc finger protein GLI1 (Gli1) marks mesenchymal progenitors responsible for both normal bone formation and fracture repair.
FLT3 (zeige FLT3 Proteine)-mutated in contrast to FLT3 (zeige FLT3 Proteine) wildtype cells or normal human hematopoietic progenitor cells are exquisitely sensitive to combined inhibition by FLT3 (zeige FLT3 Proteine), PI3K and GLI1/2 overcoming some of the limitations of current FLT3 (zeige FLT3 Proteine) directed therapy in AML (zeige RUNX1 Proteine).
The Function of SDF-1-CXCR4 Axis in SP Cells-Mediated Protective Role for Renal Ischemia/Reperfusion Injury by SHH/GLI1-ABCG2 Pathway
Shh (zeige SHH Proteine) production and Gli signaling is activated in vivo in lung, enhancing the Th2 response during a murine model of allergic asthma
Gli1-expressing bone marrow cells are responsible for primary myelofibrosis in a transgenic mouse model.
Results indicate that GLI1 is important for maintaining the invasive and mesenchymal-like properties of melanoma cells independent of MITF (zeige MITF Proteine).
USP21 (zeige USP21 Proteine) recruits and stabilises Gli1 at the centrosome.
High Gli1 expression is associated with leukemia.
Sufu (zeige SUFUH Proteine) is upregulated in active Shh (zeige SHH Proteine) responding tissues and accompanies Gli activators translocating into and Gli repressors out of the nucleus.
Gli1 and Gli2 exhibited different functions in the regulation of p63 expression or proliferation of p63(+) cells in Kras-AR driven tumors.
This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene.
glioma-associated oncogene 1
, glioma-associated oncogene homolog 1 (zinc finger protein)
, oncogene GLI
, zinc finger protein GLI1
, GLI-Kruppel family member GLI1
, GLI family zinc finger 1, gene 1
, zinc finger DNA binding protein Gli-1
, glioma-associated oncogene homolog
, zinc finger protein 5