This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010].
Kim, Sung, Youn, Park: "Gremlin-1 activates Akt/STAT3 signaling, which increases the glycolysis rate in breast cancer cells." in: Biochemical and biophysical research communications, Vol. 533, Issue 4, pp. 1378-1384, (2020) (PubMed).
Aliase für GREM1 Proteine
gremlin 1a, DAN family BMP antagonist (grem1a) Proteine gremlin 1, DAN family BMP antagonist (GREM1) Proteine gremlin 1 (LOC662541) Proteine gremlin 1, DAN family BMP antagonist (grem1) Proteine gremlin 1, DAN family BMP antagonist (Grem1) Proteine gremlin 1, DAN family BMP antagonist L homeolog (grem1.L) Proteine Cktsf1b1 Proteine CKTSF1B1 Proteine cktsf1b1 Proteine dand2 Proteine DAND2 Proteine drm Proteine Drm Proteine DRM Proteine Grem Proteine grem1 Proteine GREM1 Proteine gremlin Proteine GREMLIN Proteine gremlin-1 Proteine ihg-2 Proteine IHG-2 Proteine ld Proteine MGC136702 Proteine pig2 Proteine zgc:136702 Proteine