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CA19.9 appears as a physiological product whose synthesis strongly depends on the tissue specific and epigenetically-regulated expression of B3GALT5 (zeige B3GALT5 ELISA Kits) and ST3GAL3.
ST3Gal3 knockdown synergistically enhanced cisplatin-induced apoptosis in ovarian cancer cells
ST3Gal III modulates breast cancer cell adhesion and invasion by altering the expression of invasion-related molecules.
Dysfunctional ST3GAL3 may result in perturbation of the posttranslational sialylation of proteins in these pathways
ST3GAL3 mutations impair the development of higher cognitive functions.
Expression of ST3Gal IV (zeige ST3GAL4 ELISA Kits) in several gastrointestinal cell lines is correlated with the expression of sialyl Lewis x (zeige FUT4 ELISA Kits) at the cell surface.
Characterization of the promoter region of the ST3Gal III gene.
19 different transcripts of ST3GalIII were isolated and cloned; tissue distribution analysis showed complex patterns in neural and muscular tissues
High levels of ST3GAL-III in the tumor tissue correlated with secondary local tumor recurrence (p = 0.005; p = 0.012).
Identification of a new ST3Gal3 transcript from fetal brain.
St3gal2 (zeige ST3GAL2 ELISA Kits)/3 double-null mice displayed dysmyelination marked by a reduction in major myelin proteins, fewer myelinated axons, a decrease in myelin thickness, possibly by dysregulation of ganglioside-mediated oligodendroglial precursor cell proliferation.
mRNA levels of St3gal3 potentially involved in antithrombin (zeige SERPINC1 ELISA Kits) sialylation, were 85% lower in neonates in comparison with adults.
these studies demonstrate that ST3Gal-III plays an important role in Siglec-F (zeige SIGLEC5 ELISA Kits) ligand formation and eosinophil apoptosis with resultant effects on eosinophilic inflammation in the lung.
The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi apparatus but can be proteolytically processed to a soluble form. This protein is a member of glycosyltransferase family 29. Mutations in this gene have been associated with autosomal recessive nonsymdromic mental retardation-12 (MRT12). Multiple transcript variants encoding several different isoforms have been found for this gene.
, CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase
, alpha 2,3-sialyltransferase ST3Gal III
, alpha-2,3-sialyltransferase III
, Gal beta-1,3(4)GlcNAc alpha-2,3 sialyltransferase
, ST3Gal III
, alpha 2,3-ST 3
, alpha 2,3-sialyltransferase III
, alpha-2,3-sialyltransferase II
, sialyltransferase 6 (N-acetyllacosaminide alpha 2,3-sialyltransferase)
, sialyltransferase 6
, sialyltransferase ST3Gal-III
, N-acetyllactosaminide alpha-2,3-sialyltransferase
, beta-galactoside alpha-2,3-sialyltransferase 3
, gal beta-1,3(4) GlcNAc alpha-2,3 sialyltransferase
, sialyltransferase (N-acetyllacosaminide alpha 2,3-sialyltransferase)
, sialyltransferase 3
, N-acetyllacosaminide alpha 2,3-sialyltransferase
, sialyltransferase (N-acetyllacosaminide alpha 23-sialyltransferase)
, sialyltransferase 6(N-acetyllacosaminide alpha 23-sialyltransferase)
, CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3- sialyltransferase
, N-acetyllactosaminide alpha-2,3- sialyltransferase
, gal beta-1,3(4)GlcNAc alpha-2,3 sialyltransferase
, ST3 beta-galactoside alpha-2,3-sialyltransferase 3