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anti-Mouse (Murine) HMMR Antikörper:
anti-Rat (Rattus) HMMR Antikörper:
anti-Human HMMR Antikörper:
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Human Polyclonal HMMR Primary Antibody für ELISA, ICC - ABIN4350366
Krishnamurthy, Stout, Sapp, Matuska, Lauer, Grande-Allen: Dysregulation of hyaluronan homeostasis during aortic valve disease. in Matrix biology : journal of the International Society for Matrix Biology 2016
RHAMM localises at the mitotic spindle of ovarian granulosa cells via its C-terminus, deletion of which impairs proper spindle orientation and folliculogenesis.
RHAMM is not found on the cell-surface of embryonic stem cells, but it is required to maintain pluripotency and its dominant mechanism of action is through the modulation of signal transduction pathways at microtubules
Hyaluronon acid activation of RHAMM significantly impacts smooth muscle cell-ECM (zeige MMRN1 Antikörper) adhesive interactions and contributes to constrictive artery wall remodeling in mice.
This study demonistrated that Rhamm expression in adult mouse subventricular zone and rostral migratory stream and in ischemic cortex.
Overexpressing RHAMM was located intracellular and activated ERK1/2 (zeige MAPK1/3 Antikörper).
Results suggest that the CD44 (zeige CD44 Antikörper) and RHAMM receptors function on membrane lipid rafts during Cryptococcus neoformans invasion.
RHAMM isoform B promotes liver metastasis in a mouse model of multistep tumorigenesis.
intracellular RHAMM(Delta163) functions as an adaptor protein to control microtubule polymerization during interphase and mitosis as a result of localizing ERK1/2 (zeige MAPK1/3 Antikörper)-MEK1 (zeige MAP2K1 Antikörper) complexes to their tubulin (zeige TUBB Antikörper)-associated substrates
Gene deletion of Rhamm attenuates the formation of aggressive fibromatosis.
CD44 (zeige CD44 Antikörper) and RHAMM are molecularly redundant and have roles in a model of arthritis and inflammation
RHAMM, most likely RHAMMv3 (RHAMMB), can serve as a prognostic factor for lung adenocarcinomas and a potential therapeutic target in non-small cell lung carcinoma to inhibit tumor migration
Data show that receptor of hyaluronan-mediated motility (RHAMM) mRNA expression in breast cancer biopsies is inversely correlated with tumor grade and overall survival.
spindle-associated (zeige HAUS1 Antikörper) RHAMM as an intrinsic regulator of male germ cell fate and as a gatekeeper preventing initiation of testicular germ cell tumors (TGCT).
Overexpression of the hyaluronan receptor HMMR in primary LUAD was associated with an inflammatory molecular signature and poor prognosis. Attenuating HMMR in LUAD cells diminished their ability to initiate lung tumors and distant metastases.
The present study suggests that RHAMM is a novel beta-catenin (zeige CTNNB1 Antikörper) intracellular binding partner, protecting beta-catenin (zeige CTNNB1 Antikörper) from degradation and supporting the nuclear translocation of this key cellular mediator
RHAMM expression identifies an aggressive subpopulation of tumor budding cells and is an independent adverse prognostic factor for colorectal cancer patients.
a causative link between altered function of AURKA-HMMR-TPX2-TUBG1 and breast carcinogenesis in BRCA1/2 mutation carriers
Identify RHAMM as a critical regulator of TPX2 (zeige TPX2 Antikörper) location/ Aurora kinase A (zeige AURKA Antikörper) signaling and suggest that RHAMM ensures bipolar spindle assembly and mitotic progression through the integration of biochemical and structural pathways.
RHAMM might be a promising marker to identify early stage (nodal negative) patients at risk for dismal survival, who may benefit from specific adjuvant therapies.
analysis of the role of growth factors in Hyaluronan/RHAMM interactions in mesenchymal tumor pathogenesis [review]
The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
hyaluronan mediated motility receptor
, intracellular hyaluronic acid-binding protein
, receptor for hyaluronan-mediated motility
, hyaluronan-mediated motility receptor