anti-HAS1 (HAS1) Antikörper

Human Hyaluronan Synthase 1 (HAS1) Interaktionspartner

1. Reduced expression of HAS1 and HAS2 (zeige HAS2 Antikörper) is associated with melanoma progression and suggests that HAS1 and HAS2 (zeige HAS2 Antikörper) have a prognostic significance in cutaneous melanoma.

2. Regulation of Hyaluronan (HA) Metabolism Mediated by HYBID (Hyaluronan-binding Protein Involved in HA Depolymerization, KIAA1199 (zeige KIAA1199 Antikörper)) and HA Synthases in Growth Factor-stimulated Fibroblasts.

3. The minor allele genotypes of HAS1 SNPs are significantly more frequent in MM, WM, CLL and in affected members of a monoclonal gammopathy-prone family than they are in breast cancer, sporadic MGUS or healthy donors

4. transcriptional regulation of the HAS and HAS2 (zeige HAS2 Antikörper)-antisense RNA 1 genes, was analyzed.

5. HAS1 is the main enzyme responsible for hyaluronan production by normal keratinocytes.

6. The HAS1-dependent coat is induced by inflammatory agents and glycemic stress, mediated by altered presentation of either CD44 (zeige CD44 Antikörper) or hyaluronan, and can offer a rapid cellular response to injury and inflammation.

7. Among the genes affected by FAK (zeige PTK2 Antikörper) or HAS3 (zeige HAS3 Antikörper) inhibition were genes, playing role in apoptosis, cell cycle regulation, adhesion, transcription, heatshock and WNT (zeige WNT2 Antikörper) pathways.

8. Inverse expression of hyaluronidase 2 (zeige HYAL2 Antikörper) and hyaluronan synthases 1-3 is associated with reduced hyaluronan content in malignant cutaneous melanoma.

9. aberrant intronic HAS1 splicing in multiple myeloma patients may rely on intronic HAS1 deletions and mutations that are frequent in MM patients but absent from healthy donors

10. TGF-beta1 (zeige TGFB1 Antikörper) up-regulation of HAS1 transcription was mediated via Smad3 (zeige SMAD3 Antikörper) but not Smad2 (zeige SMAD2 Antikörper), while HAS1 induction by IL-1beta (zeige IL1B Antikörper) was Sp3 (zeige SP3 Antikörper), not Sp1 (zeige PSG1 Antikörper), dependent.

Pig (Porcine) Hyaluronan Synthase 1 (HAS1) Interaktionspartner

1. The HA concentration in follicular fluids increased during atresia and HAS1 may be the dominant HAS protein in theca cells to produce HA in pig ovaries.

Mouse (Murine) Hyaluronan Synthase 1 (HAS1) Interaktionspartner

1. In the present study, we examined expression patterns of Has1, -2, -3 mRNA in developing mouse molar and incisor tooth germs from embryonic day (E) 11.5 to postnatal day (P) 7, focusing on Hertwig's epithelial root sheath (HERS) and the apical bud in particular. Has1 mRNA expression was not detected in all tooth germs examined

2. HAS1 was significantly upregulated at the level of gene expression during muscle hypertrophy.

3. analysis of changes in cervical glycosaminoglycan composition during normal pregnancy and preterm birth: Has1 is expressed in preterm birth, while Has2 (zeige HAS2 Antikörper) is induced at term

4. Selective loss of Has1 and Has3 (zeige HAS3 Antikörper) leads to a proinflammatory milieu that favors recruitment of neutrophils and other inflammation-related changes in the dermis.

5. repression of HA-accumulation by both COX-2 (zeige COX2 Antikörper) selective and non-selective COX (zeige CPOX Antikörper) inhibition implicates COX-2 (zeige COX2 Antikörper) in the regulation of HA synthesis via stimulation of HAS1 and HAS2 (zeige HAS2 Antikörper) expression in vivo

6. Has-1 transduced ASMCs accumulated the greatest amount of HA containing ECM (zeige MMRN1 Antikörper) than the other transduced ASMCs.Confocal microscopy showed CD44 (zeige CD44 Antikörper) positive monocytes bound to hyaluronidase (zeige HAase Antikörper) sensitive ECM (zeige MMRN1 Antikörper) in has-1 transduced ASMCs.