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Human Polyclonal GNA11 Primary Antibody für WB - ABIN1881378
Gavard, Gutkind: Protein kinase C-related kinase and ROCK are required for thrombin-induced endothelial cell permeability downstream from Galpha12/13 and Galpha11/q. in The Journal of biological chemistry 2008
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GNAQ/GNA11Q209 mutations characterized a distinct, albeit uncommon subtype of non-uveal melanoma (0.5-1%). These mutations were essentially melanoma-specific, occurred in all subtypes of this disease (including cutaneous, mucosal, uveal, and unknown primary), and were mutually exclusive with other common melanoma mutations.
GNA11 mutations are associated with extremity capillary malformations causing overgrowth.
There were no significant differences in the prevalence of GNAQ (zeige GNAQ Antikörper) and GNA11 mutations between patients with or without metastatic disease
a novel germline gain-of-function Galpha11 mutation, Val340Met, causing Autosomal Dominant Hypocalcemia Type 2 demonstrates the importance of the Galpha11 C-terminal region for G-protein function and CaSR (zeige CASR Antikörper) signal transduction.
studies have identified a third Galpha11 mutation (Thr54Met) causing Familial Hypocalciuric Hypercalcemia Type 2 and reveal a critical role for the Galpha11 interdomain interface in CaSR (zeige CASR Antikörper) signaling and Ca(2 (zeige CA2 Antikörper)+) o homeostasis.
Adenocarcinomas or adenomas derived from pigmented ciliary epithelium is distinguished from uveal melanoma by the absence of SOX10 (zeige SOX10 Antikörper) expression and presence of the BRAF (zeige BRAF Antikörper) V600E mutation.
Mutations in GNAQ (zeige GNAQ Antikörper) and GNA11 genes in Greek uveal melanoma population present frequencies that qualify them as potential targets for customized therapy.
Sporadic melanotic schwannoma with overlapping features of melanocytoma bearing a GNA11 mutation in an adolescent girl.
we find iris melanomas to be related genetically to choroidal and ciliary body melanomas, frequently harboring GNAQ (zeige GNAQ Antikörper), GNA11, and EIF1AX (zeige EIF1AX Antikörper) mutations.
GNAQ and GNA11 mutations occur frequently in mucosal melanoma and may be a prognostic factor for MM. Our data implicate that GNAQ/11 may be potential targets for targeted therapy of mucosal melanoma.
G protein-coupled receptor Kinase 2 reacts with this protein's signaling homology domain for binding G protein subunits
The phylogenetic trees reveal that porcine Gna11, is evolutionarily close to the human homolog.
Galpha11 is inhibitory to osteoanabolic actions of both parathyroid hormone (zeige PTH Antikörper) and exercise
results suggest that alveolar Gq/11 signaling maintains alveolar homeostasis and likely independently increases TGFbeta (zeige TGFB1 Antikörper) activation in response to the mechanical stress of the epithelium and decreases epithelial IL-33 (zeige IL33 Antikörper) synthesis. Together, these findings suggest that disruption of Gq/11 signaling promotes inflammatory emphysema but protects against mechanically induced lung injury.
the results have identified 138 and 150 ovarian genes that are up-regulated or down-regulated, respectively, at the end of gestation in a Galphaq (zeige GNAQ Antikörper)/11-dependent fashion.
claudin-3 (zeige CLDN3 Antikörper) and claudin-5 (zeige CLDN5 Antikörper) expression is increased by DHEAS (zeige SULT2A1 Antikörper) and tight junction formation is stimulated via a Gnalpha11-coupled receptor in Sertoli cells
ZIP9/Gna11 interactions mediate the non-classical testosterone signaling cascade in spermatogenic GC-2 cells.
the conditional deletion of Galphaq (zeige GNAQ Antikörper)/11 from granulosa/luteal cells prevents the progesterone withdrawal that occurs at the end of pregnancy and impairs parturition.
Loss of gq/11 genes does not abolish melanopsin (zeige OPN4 Antikörper) phototransduction.
Mediated by lysophosphatidylinositol, Galpha(q (zeige GNAQ Antikörper)/11) is activated in sensory neurons.
Dehydroepiandrosterone sulfate (DHEAS (zeige SULT2A1 Antikörper))-induced signaling is mediated through interaction with a membrane-bound G-protein-coupled receptor (zeige GPR34 Antikörper), since silencing of Gnalpha11 leads to the abolition of the DHEAS (zeige SULT2A1 Antikörper)-induced stimulation of Erk1/2, ATF-1 (zeige AFT1 Antikörper), and CREB (zeige CREB1 Antikörper).
Pasteurella multocida toxin prevents osteoblast differentiation by transactivation of the MAP-kinase (zeige MAPK1 Antikörper) cascade via the Galpha(q (zeige GNAQ Antikörper)/11)--p63RhoGEF--RhoA (zeige RHOA Antikörper) axis.
may be involved in mediating second messenger signals from the endothelin receptor in adipocytes
Guanine nucleotide-binding protein alpha-11 subunit
, phospholipase C-activating G-protein
, G-protein subunit alpha-11
, g alpha-11
, guanine nucleotide-binding protein G(y) subunit alpha
, guanine nucleotide-binding protein subunit alpha-11
, guanine nucleotide-binding protein, Gq class, GNA11
, G-protein subunit GL2 alpha
, G alpha-11
, guanine nucleotide binding protein alpha 11
, guanine nucleotide regulatory protein G alpha 11
, guanine nucleotide-binding protein alpha 11 subunit