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anti-Human POU4F1 Antikörper:
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Human Polyclonal POU4F1 Primary Antibody für IF (p), IHC (p) - ABIN702400
Xue, Qian, Hu, Zhou, Zhou, Hu, Karakhanyan, Pang, Fu: Sequential regulatory loops as key gatekeepers for neuronal reprogramming in human cells. in Nature neuroscience 2016
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We report a case of a nine-year-old male who presented with facial nerve stimulation four years after cochlear implantation. A dilated internal auditory meatus was revealed. Genetic analysis demonstrated X-linked deafness type 2 (DFNX2) caused by a novel c.769C T nucleotide change in the POU domain, class 3, transcription factor 4 gene
Brn3a cooperates with activated RAS/RAF signalling by reducing oncogene-induced senescence in melanocytic tumourigenesis.
Data indicate that median methylation levels of BCAN, HOXD1, KCTD8, KLF11, NXPH1, POU4F1, SIM1, and TCF7L1 were >/=30% higher than in normal samples, representing potential biomarkers for tumor diagnosis.
PoU4F1 is highly expressed in t(8;21) samples, with AML/ETO appearning to promote some BRN3A expression
BRN3A possesses anti-apoptotic property, and considering the above results, it may be regarded as the key component in promoting tumorigenic growth in the uterine cervical cells.
Ewing sarcoma induce expression of neuronal markers such as BRN3A showing that the function of those same markers may be restricted or controlled in an sarcoma-dependent manner.
Dysregulation of POU4F1 is associated with t(8;21) acute myeloid leukemia.
genomic organization of the Brn-3a locus and the mechanisms that control the expression of two different proteins from one genomic locus
Measurement of Brn-3a levels in smears can be used to detect a significant proportion of cervical lesions that were missed by Pap smear.
These results indicate that Brn-3a could play an important role in the near future in improving cervical cancer screening.
oncogenic rearrangement of EWS to produce EWS/Fli-1 may enhance the antiapoptotic effect of Brn-3a and inhibit its ability to promote neuronal differentiation.
Hsp27 expression and cell survival are regulated by the POU transcription factor Brn3a
Brn-3a has a role in differential regulation of different human papilloma virus variants
Upregulation of Brn-3a is associated with prostate cancer
This study showed that three genes were found to be consistently regulated by Brn3a throughout postnatal retina development - Mapk10, Tusc5 and Cdh4.
Double morphant embryos targeted with morpholino oligonucleotides to both TFs develop significant cardiac defects (looping abnormalities and valve defects) suggesting essential roles for Brn-3a and Brn-3b in developing hearts.
Study demonstrates a sequential expression order of NEUROD1>ISL1>POU4F1>POU4F2 during the inner ear neurogenesis.
Pou4f1 and pou4f2 are dispensable for the long-term survival of adult retinal ganglion cells in mice.
The deficiency of Pou4f1 who perform poorly in motivation-based locomotor behaviors, such as voluntary wheel running and the accelerating rotarod, but show only minor abnormalities in gait and balance and exhibit normal levels of basal locomotion.
Data indicate that Brn3 transcription factors Brn3b affects Brn3a and Brn3c positive Retinal Ganglion Cells (RGCs) in cell autonomous and non-cell autonomous fashion.
The results demonstrated a critical role for Brn3a in generating dorsal root ganglia sensory neuron diversity and regulating sensory afferent projections to the central targets.
neither Brn3a nor Brn3c are expressed in intrinsically photosensitive retinal ganglion cells
Brn3 gene expression patterns in the retina and inner ear, these experiments suggest a deep functional similarity among primary somatosensory neurons, spiral and vestibular ganglion neurons, and retinal ganglion cells
Progressive increase in IOP and loss of Brn3a signals in D2 animals were consistent with glaucoma progression starting after 6 months of age.
An epistatic interaction between Brn3a and Isl1 is key to sensory neuron specification, in their absence almost all known markers of sensory neurons are lost. Data support the hypothesis that Brn3a and Isl1 bind to shared enhancers in target genes.
Data show a longitudinal domain positive for both Nkx6.1 and Nkx6.2 that is medial to the Pou4f1-positive red nucleus. This domain could correspond to part of the reticular formation, which extends from the diencephalon and the mesencephalon.
data define AR as a direct Brn-3a interactor and verify a simple interacting protein prediction methodology that is likely to be useful for many other proteins
Data show that Brn3a acts upstream of the Runx factors, which then repress TrkB expression to allow establishment of the non-overlapping Trk receptor profiles and correct terminally differentiated phenotypes.
Brn3a regulates the transition from neurogenesis to terminal differentiation and represses non-neural gene expression in the trigeminal ganglion.
Deficiency of Brn-3a may cause the increase and decrease of Cgrp-immunoreactive expression in small dorsal root ganglion (DRG) neurons projecting to the dorsal column and large DRG neurons projecting to the deep dorsal horn, respectively.
Nociceptors and low-threshold mechanoreceptors with medium-sized to large cell bodies in the trigeminal ganglion may be sensitive to the loss of Brn-3a.
Brn3a locus functions as a self-regulating unit to maintain a constant expression level of this key regulator of neural development.Sensory expression of Brn3a is regulated by a specific enhancer, Brn3a binds to conserved sites within this enhancer
Axon growth is markedly disturbed in Brn3a knockout mice; it is unlikely that Brn3a targets Bcl-2 or mediates the defects in axon guidance and neuronal survival observed in the sensory ganglia of Brn3a knockout mice.
This gene encodes a member of the POU-IV class of neural transcription factors. This protein is expressed in a subset of retinal ganglion cells and may be involved in the developing sensory nervous system. This protein may also promote the growth of cervical tumors. A translocation of this gene is associated with some adult acute myeloid leukemias.
POU domain, class 4, transcription factor 1
, brain-specific homeobox/POU domain protein 3A
, homeobox/POU domain protein RDC-1
, POU class 4 homeobox 1
, brain-specific homeobox/POU domain protein 3a
, class IV POU-homeodomain protein
, LOW QUALITY PROTEIN: POU domain, class 4, transcription factor 1