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Our results indicate a possible contribution of CNVs in LEPR (zeige LEPR Proteine), NEGR1, ARHGEF4 (zeige ARHGEF4 Proteine), and CPXCR1 (zeige CPXCR1 Proteine) and the intergenic regions 12q15c, 15q21.1a, and 22q11.21d to the development of obesity, particularly abdominal obesity in Mexican children.
NEGR1, strong candidate gene, associated with clinical features of Depression (e.g., earlier age at onset and recurrent and more severe forms of Depression). Gene expression patterns in the prefrontal and anterior cingulate cortex most closely matched the genetic findings.
Single nucleotide polymorphism in NEGR1 gene is associated with major depressive disorder.
Significant associations were identified at 3.5 years old for TMEM18 (zeige TMM18 Proteine) rs6548238, NEGR1 rs2815752, BDNF (zeige BDNF Proteine) rs10767664 and rs6265 (1 year old and 3.5 years old) with anthropometric phenotypes
NEGR1 interacts with NPC2 (zeige NPC2 Proteine) and increases its protein stability; it has a role in obesity
We observed novel selection signals in CDKAL1 (zeige CDKAL1 Proteine) and NEGR1, well-known diabetes and obesity susceptibility genes
NEGR1 could be an important locus influencing certain personality dimensions in BN patients.
First study to find an association between an obesity risk gene and differences in white matter integrity. As our subjects were young and healthy, our results suggest that NEGR1 has effects on brain structure independent of its effect on obesity.
Data indicate strong associations with severe obesity for single nucleotide polymorphism (SNP) rs9939609 within the FTO (zeige FTO Proteine) gene and SNP rs2815752 near the NEGR1 gene.
Results imply a regulatory role for TMEM18 (zeige TMM18 Proteine), BDNF (zeige BDNF Proteine), MTCH2 (zeige MTCH2 Proteine) and NEGR1 in adipocyte differentiation and biology. In addition, we show a variation of MAF (zeige MAF Proteine) expression during adipogenesis, while NPC1 (zeige NPC1 Proteine), PTER (zeige PTER Proteine) and SH2B1 (zeige SH2B1 Proteine) were not regulated.
The long non-coding RNA, BC048612, and microRNA-203 were determined to be positive and negative regulators of Negr1 gene expression respectively.
Negr1 controls the development of neurite arborization in vitro and in vivo.
a role of NEGR1 in the control of body weight and food intake
These results suggest a function for neurotractin/kilon as a trans-neural growth-promoting factor for outgrowing axons following hippocampal denervation.
glycosylphosphatidylinositol-anchored cell adhesion protein
neuronal growth regulator 1
, neuronal growth regulator 1-like
, IgLON family member 4
, a kindred of IgLON
, kindred of IgLON
, kilon protein