anti-Spleen tyrosine Kinase (SYK) Antikörper

Human Spleen tyrosine Kinase (SYK) Interaktionspartner

1. NF-kappaB and Syk signaling pathways are instrumental for cancer progression. (Review)

2. Calcium phosphate particles stimulate SYK and caspase-1 activation in vascular smooth muscle cells, leading to the release of IL-1beta, at least in part via exosomes.

3. Aberrant SYK overexpression in monomorphic epitheliotropic intestinal T-cell lymphoma is likely caused by hypomethylation of the SYK promoter, while no common mutations in the SYK gene or in its promoter could be detected.

4. Low SYK(L) expression is associated with epithelial-to-mesenchymal transition in lung cancer.

5. After blocking the beta-glucan receptor (CR3) or inhibiting downstream kinase (SYK) in neutrophils, the killing percent to C. albicans (regardless of endemic and non-endemic strains) and the ratio of LC3B-II/I of neutrophils were significantly decreased.

6. Results suggest that Syk, MAP4, and calpain-1 expression are correlated with each other and these proteins may be involved in early stages of tumour spread.

7. integrin cytoplasmic domains do not directly induce Syk conformational changes and do not activate Syk via the same mechanism as double-phosphorylated immunoreceptor tyrosine-based activation motif.

8. The LMP2A of Epstein-Barr Virus was found to interfer with cofilin degradation in nasopharyngeal cancer cells by accelerating the proteasomal degradation of Cbl and Syk.

9. Study of skin biopsy samples from bullous pemphigoid patients and immunization-induced murine experimental epidermolysis bullosa identified SYK expression in dermal myeloid cells as a requirement to promote inflammation in autoantibody-driven pathologies.

10. hese results implicate that Syk controls oxidative stress-induced human B cell death via nuclear translocation of Nrf2 and MMP collapse. These results suggest that Syk is a novel regulator of Nrf2 activation.

11. A new mechanism by which SYK signaling regulates ovarian cancer cell motility.

12. High SYK expression is associated with Intestinal Inflammation and Immune Dysfunction in Inflammatory Bowel Diseases.

13. High SYK expression is associated with glioma.

14. In this article, the authors have shown that Natural killer cells can reduce their functional role through downregulation of Syk and Zap70 kinases.

15. DFNA5 variant is associated with tobacco- and HPV-mediated oral oncogenesis.

16. This study identifies a novel signaling involving SYK/c-MYC/MALAT1 as a promising therapeutic target for the treatment of Ewing sarcoma.

17. Comparison of the distributions of tau pTyr18 and double-phosphorylated Syk in the transgenic mouse brain and human hippocampus showed that the phosphorylation of tyrosine 18 in tau already occurs at an early stage of tauopathy and increases with the progression of neurodegeneration. Syk appears unlikely to be a major kinase that phosphorylates tyrosine 18 of tau at the early stage of tauopathy.

18. Results show that Syk activation occurs following Abeta deposition and the formation of tau pathological species. As Syk activation also promotes Abeta formation and tau hyperphosphorylation, results suggest that Alzheimer's disease pathological lesions may be self-propagating via a Syk dependent mechanism highlighting Syk as an attractive therapeutic target for the treatment of Alzheimer's disease.

19. study reports that neutrophils constitutively express various Src family isoforms as well as Syk, and that inhibition of these protein tyrosine kinases selectively hinders inflammatory cytokine generation by acting posttranscriptionally

20. expressed by immune cells and keratinocytes in skin lesions of cutaneous lupus erythematosus patients

Mouse (Murine) Spleen tyrosine Kinase (SYK) Interaktionspartner

1. Mice deficient in macrophage C-type lectin protein (Mincle) or with selective depletion of tyrosine-protein kinase SYK (Syk) had increased systemic translocation of gut microbiota.

2. Our findings allude to the involvement of SYK in the regulation of innate immune cells such as gammadelta T cells and neutrophils in the context of acute lung injury (ALI) for the first time. Further, our study shows that SYK inhibitor, R406 enhances the survival rate of mice with ALI probably by controlling overtly aggressive innate immune cells through downregulation of inflammatory cytokines and oxidative stress.

3. Results indicate that autoantibody-induced arthritis requires Syk kinase (Syk) expression in neutrophils.

4. These results suggested that the Syk/JNK signaling pathway may play a vital role in the inflammasome activation and modulate host immune responses against S. pneumoniae.

5. Syk induced the activation of the PI3K/Akt pathway upon gammadeltaTCR stimulation. Mice deficient in PI3K signaling exhibited a complete loss of gammadeltaT17, without impaired development of IFN-gamma-producing gammadeltaT cells.

6. this study shows that SYK-CARD9 signaling promotes gut Fungi-mediated inflammasome activation to restrict colitis and colon cancer

7. Study of skin biopsy samples from bullous pemphigoid patients and immunization-induced murine experimental epidermolysis bullosa identified SYK expression in dermal myeloid cells as a requirement to promote inflammation in autoantibody-driven pathologies.

8. SEA-induced NLRP3 inflammasome activation in HSCs is dependent upon the activities of spleen tyrosine kinase (Syk).

9. study proposes that Syk signaling in DCs and neutrophils plays a critical role during sepsis-induced acute kidney injury (AKI). Therefore, Syk inhibition in innate immune cells might serve as an effective strategy to limit inflammatory cascade during AKI.

10. High SYK expression is associated with Intestinal Inflammation and Immune Dysfunction in Inflammatory Bowel Diseases.

11. High SYK expression is associated with glioma.

12. Cryptotanshinone inhibits IgEmediated degranulation through inhibition of spleen tyrosine kinase and tyrosineprotein kinase phosphorylation in mast cells.

13. Results indicate spleen tyrosine kinase (SYK) as an essential mediator of brown fat formation and function.

14. CD11b promotes the differentiation of osteoclasts induced by RANKL through the Syk signaling pathway.

15. Phosphorylation levels of 10 phosphosites in spleen tyrosine kinase (SYK) were increased following B cell receptor activation. 4 cluster regions, encompassing 8 phosphosites, were activated by mercury. Phosphorylation of tyrosine-342 and -346 residues were most sensitive to mercury exposure.

16. Comparison of the distributions of tau pTyr18 and double-phosphorylated Syk in the transgenic mouse brain and human hippocampus showed that the phosphorylation of tyrosine 18 in tau already occurs at an early stage of tauopathy and increases with the progression of neurodegeneration. Syk appears unlikely to be a major kinase that phosphorylates tyrosine 18 of tau at the early stage of tauopathy.

17. Syk kinase acts downstream of receptors controlling granule cells tangential migration

18. Results show that Syk activation occurs following Abeta deposition and the formation of tau pathological species. As Syk activation also promotes Abeta formation and tau hyperphosphorylation, results suggest that Alzheimer's disease pathological lesions may be self-propagating via a Syk dependent mechanism highlighting Syk as an attractive therapeutic target for the treatment of Alzheimer's disease.

19. Syk-induced signals in bone marrow stromal cell lines are mediated by phospholipase C gamma1 (PLCgamma1) in osteogenesis and PLCgamma2 in adipogenesis.

20. Study demonstrates that redundant complexes formed by the mutant SYK(Y3F) protein allow it to maintain signaling to receptor-proximal interaction partners, resulting in proper initiation of BCR-proximal signals.

Cow (Bovine) Spleen tyrosine Kinase (SYK) Interaktionspartner

1. These data suggest that Syk mRNA expression dynamics is closely related to bovine leukemia virus-induced disease.