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F13A1 Proteine

(Coagulation Factor XIII, A1 Polypeptide (F13A1))
This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits\; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008].

Häufig verwendete F13A1 Proteine

Aliase für F13A1 Proteine

coagulation factor XIII A1 chain (F13a1) Proteine
coagulation factor XIII, A1 polypeptide b (f13a1b) Proteine
coagulation factor XIII A chain (F13A1) Proteine
coagulation factor XIII, A1 subunit (F13a1) Proteine
coagulation factor XIII A chain (F13a1) Proteine
1200014I03Rik Proteine
AI462306 Proteine
F13a Proteine
F13A Proteine
f13a1 Proteine
F13A1 Proteine
wu:fo83d04 Proteine
zgc:153334 Proteine
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