VAPB Proteine (VAPB)

Bezeichnung:: VAMP (Vesicle-Associated Membrane Protein)-Associated Protein B and C Proteine (VAPB)

Auf www.antikoerper-online.de finden Sie aktuell 17 VAMP (Vesicle-Associated Membrane Protein)-Associated Protein B and C (VAPB) Proteine von 9 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen VAPB Antikörper (98) und VAPB Kits (7) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 128 VAPB Produkte verfügbar.

Synonyme:: AI225786, AI840687, AI848259, ALS8, D2Abb2e, fc05d09, R75548, vamp-b, vamp-c, Vamp33b, vap-b, vap-c, VAP33b, vapb, wu:fa96d05, wu:fc05d09, zgc:66045

alle Proteine anzeigen	Gen	GeneID	UniProt
	VAPB	9217	O95292
Ratte VAPB	VAPB	60431	Q9Z269
Maus VAPB	VAPB	56491
Weitere Synonyme anzeigen

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Verknüpfte Pathways mit VAPB Proteine

ER-Nucleus Signaling

Weitere Produktkategorien zu VAPB Protein

Weitere Proteine zu VAPB Interaktionspartnern

Human VAMP (Vesicle-Associated Membrane Protein)-Associated Protein B and C (VAPB) Interaktionspartner

report on a novel mutation of p.Pro56His in VABP (zeige KCNIP1 Proteine) found in a Chinese familial amyotrophic lateral sclerosis pedigree and description of the clinical characteristics of the family.
the component proteins of the machinery, OSBP (zeige OSBP Proteine), VAP (zeige F10 Proteine), SAC1 (zeige SACM1L Proteine), and PITPNB (zeige PITPNB Proteine), are all essential host factors for AiV (zeige ANXA4 Proteine) replication. Importantly, the machinery is directly recruited to the RNA replication sites through previously unknown interactions of VAP (zeige F10 Proteine)/OSBP (zeige OSBP Proteine)/SAC1 (zeige SACM1L Proteine) with the AiV (zeige ANXA4 Proteine) proteins and with ACBD3 (zeige Acbd3 Proteine).
Lifelong elevation of neuronal VAPB slowed the decline of neurological impairment, delayed denervation of hindlimb muscles, and prolonged survival of spinal motor neurons.
Study showed that alpha-synuclein perturbs endoplasmic reticulum-mitochondria associations and that this involves disruption to the VAPB-PTPIP51 (zeige FAM82A2 Proteine) tethering proteins. Using a range of assays including immunoprecipitation, cellular glutathione S-transferase (zeige GSTa2 Proteine) pull-down, proximity ligation and in vitro binding of recombinant proteins, study showed that alpha-synuclein is a direct binding partner for VAPB.
ACBD5 (zeige ACBD5 Proteine)-VAPB interaction regulates peroxisome-endoplasmic reticulum associations. Loss of PO-ER association perturbs PO membrane expansion and increases PO movement.
VAP (zeige F10 Proteine)-ACBD5 (zeige ACBD5 Proteine)-mediated contact between the endoplasmic reticulum and peroxisomes mediate organelle maintenance and lipid homeostasis.
Effects of the combined absence of VAPA (zeige VAPA Proteine) and VAPB in human cells were studied; cells lacking VAP (zeige F10 Proteine) accumulate high levels of PI4P, actin comets, and trans-Golgi proteins on endosomes. Such defects are mimicked by downregulation of OSBP (zeige OSBP Proteine), a VAP (zeige F10 Proteine) interactor and PI4P transporter that participates in VAP (zeige F10 Proteine)-dependent endoplasmic reticulum-endosomes tethers.
this is the first study to report Amyotrophic lateral sclerosis caused by a VAPB mutation in a Chinese population.
Our work revealed that VAP-A/B knockdown impaired the processing and secretion of PAUF, which is one of the cargo proteins of carriers of the trans-Golgi network to the cell surface.
Heterozygous P56S Vapb knock-in mice show mild age-dependent defects in motor behaviors as characteristic features of the disease. The homozygous P56S Vapb knock-in mice show more severe defects compared with heterozygous mice reflecting the dominant and dose-dependent effects of P56S mutation.

Mouse (Murine) VAMP (Vesicle-Associated Membrane Protein)-Associated Protein B and C (VAPB) Interaktionspartner

To identify pathological defects in animals expressing the P56S mutant VAPB protein at physiological levels in the appropriate tissues, we have generated Vapb knock-in mice
The disruption of the IRE1 (zeige ERN1 Proteine)-XBP1 (zeige XBP1 Proteine) pathway is a cause for the reduced myotube formation in P56S-VAPB-mutation expressing cells.
Vapb knock-out mice exhibit abnormal muscular triacylglycerol levels and FoxO (zeige FOXO3 Proteine) target gene transcriptional responses to fasting and refeeding
Mice knocked-out for Vapb showed mild motor deficits after 18 months of age.
VapB positively regulates RANKL (zeige TNFSF11 Proteine)-mediated osteoclastogenesis via PLCgamma2 (zeige PLCG2 Proteine)-Ca(2 (zeige CA2 Proteine)+)-NFAT (zeige NFATC1 Proteine) signaling
Co-expression of mutant protein-associated protein B (zeige LEPREL2 Proteine) (VAPB) enhances the transactive response DNA-binding protein (zeige HSF4 Proteine)-43 (TDP-43 (zeige TARDBP Proteine))-induced motor neuronal cell death while that of wild type-VAPB attenuates it.
Adeno (zeige ADORA2A Proteine)-associated viral-mediated over-expression of both wild-type and mutated form of human VAPB selectively induces death of primary motor neurons, albeit with different kinetics.
However, VAPBP56S but not VAPBwt transgenic mice develop cytoplasmic TDP-43 (zeige TARDBP Proteine) accumulations within spinal cord motor neurons that were first detected at 18 months of age.
The total loss of VAPB function in unfolded protein response, induced by one P56S mutant allele, may contribute to the development of P56SVAPB- induced amyotrophic lateral sclerosis.

VAPB Protein Überblick

Protein Überblick

The protein encoded by this gene is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking.

Alternative names and synonyms associated with VAPB

VAMP associated protein B and C (VAPB)
vesicle-associated membrane protein-associated protein B/C (Tsp_07972)
VAMP associated protein B and C (Vapb)
vesicle-associated membrane protein, associated protein B and C (Vapb)
VAMP (vesicle-associated membrane protein)-associated protein B and C (vapb)
VAMP (vesicle-associated membrane protein)-associated protein B and C L homeolog (vapb.L)

AI225786 Protein
AI840687 Protein
AI848259 Protein
ALS8 Protein
D2Abb2e Protein
fc05d09 Protein
R75548 Protein
vamp-b Protein
vamp-c Protein
Vamp33b Protein
vap-b Protein
vap-c Protein
VAP33b Protein
vapb Protein
wu:fa96d05 Protein
wu:fc05d09 Protein
zgc:66045 Protein

Bezeichner auf Proteinebene für VAPB

VAMP-associated 33 kDa protein , vesicle-associated membrane protein-associated protein B/C , VAMP (vesicle-associated membrane protein)-associated protein B and C , VAMP-associated protein B/C , VAMP-B , VAMP-associated protein B , VAP-B , vesicle-associated membrane protein, associated protein B and C , vesicle-associated membrane protein-associated protein B , VAMP-associated protein 33b , VAMP (vesicle-associated membrane protein)-associated protein B and C L homeolog

GENE ID	SPEZIES
9217	Homo sapiens
469984	Pan troglodytes
100350714	Oryctolagus cuniculus
10906529	Trichinella spiralis
60431	Rattus norvegicus
56491	Mus musculus
100144536	Sus scrofa
326580	Bos taurus
419317	Gallus gallus
100736066	Cavia porcellus
323628	Danio rerio
477274	Canis lupus familiaris
495400	Xenopus laevis

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