SEC63 Proteine (SEC63)

Bezeichnung:: SEC63 Homolog (S. Cerevisiae) Proteine (SEC63)

Auf www.antikoerper-online.de finden Sie aktuell 7 SEC63 Homolog (S. Cerevisiae) (SEC63) Proteine von 3 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen SEC63 Antikörper (39) und und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 53 SEC63 Produkte verfügbar.

Synonyme:: 5730478J10Rik, AI649014, AW319215, DNAJC23, ERdj2, PRO2507, SEC63-like, SEC63L, zgc:92718

alle Proteine anzeigen	Gen	GeneID	UniProt
	SEC63	11231	Q9UGP8
	SEC63	140740	Q8VHE0
Ratte SEC63	SEC63	309858
Weitere Synonyme anzeigen

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Verknüpfte Pathways mit SEC63 Proteine

ER-Nucleus Signaling

Weitere Produktkategorien zu SEC63 Protein

Weitere Proteine zu SEC63 Interaktionspartnern

Human SEC63 Homolog (S. Cerevisiae) (SEC63) Interaktionspartner

Results suggest that loss of PRKCSH (zeige PRKCSH Proteine) and SEC63 leads to general defects in ciliogenesis, while quenching of the Wnt (zeige WNT2 Proteine) signaling cascade is cholangiocyte-restricted.
a SEC63 germline mutation may play a role in cyst formation in polycystic liver disease
Phosphorylation of Sec63 by CK2 (zeige CSNK2A1 Proteine) enhanced its binding to Sec62 (zeige TLOC1 Proteine)
Sec63 may perform a substrate-selective quantity control function during cotranslational endoplasmic reticulum import.
Silencing the human SEC63 genes inhibits transport of only a subset of signal-peptide-containing precursor proteins to endoplasmic reticulum.
identified nucleoredoxin (zeige NXN Proteine) as an interaction partner of Sec63; characterized this interaction; Sec63 is linked to the Wnt (zeige WNT2 Proteine) signaling pathways and this interaction may be the reason why mutations in SEC63 can lead to polycystic liver disease
identified a total of 26 novel mutations in PRKCSH (zeige PRKCSH Proteine) (n = 14) and SEC63 (n = 12), including four splice site mutations, eight insertions/ deletions, six non-sense mutations, and eight missense mutations
Mutations in SEC63 cause autosomal dominant polycystic liver disease, suggesting a role for cotranslational protein-processing pathways in maintaining epithelial luminal structure and implicating noncilial ER proteins in human polycystic disease.
Sec63p expression was observed in all cyst epithelia regardless of mutational state. And, Cystogenesis in SEC63-associated PCLD (zeige PRKCSH Proteine) occurs via a different mechanism.

Mouse (Murine) SEC63 Homolog (S. Cerevisiae) (SEC63) Interaktionspartner

SEC63 function regulates IRE1alpha (zeige ERN1 Proteine)/XBP1 (zeige XBP1 Proteine) activation. SEC63 and XBP1 (zeige XBP1 Proteine) are required for GPS cleavage and maturation of PC1 (zeige PCSK1 Proteine), protecting against polycystic disease.
The pro-carcinogenic growth behavior of hepatocytes with low SEC63 expression in the murine model indicates a potential role for SEC63 in hepatocarcinogenesis in general.
Knockout of the murine Sec63 gene inhibits transport of precursor proteins into the endoplasmic reticulum.
SEC63 gene expression is up-regulated and predominantly localized in mouse decidual cells during days 5-8 of pregnancy.

Zebrafish SEC63 Homolog (S. Cerevisiae) (SEC63) Interaktionspartner

disruption of sec63 leads to abnormalities in myelinating glia in both the central and peripheral nervous systems

SEC63 Protein Überblick

Protein Überblick

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER.

Alternative names and synonyms associated with SEC63

SEC63 homolog, protein translocation regulator (SEC63)
SEC63-like (S. cerevisiae) (Sec63)
SEC63 homolog, protein translocation regulator (Sec63)
SEC63 homolog, protein translocation regulator (sec63)
SEC63 homolog, protein translocation regulator L homeolog (sec63.L)

5730478J10Rik Protein
AI649014 Protein
AW319215 Protein
DNAJC23 Protein
ERdj2 Protein
PRO2507 Protein
SEC63-like Protein
SEC63L Protein
zgc:92718 Protein

Bezeichner auf Proteinebene für SEC63

translocation protein SEC63 homolog , SEC63-like protein , SEC63-like

GENE ID	SPEZIES
11231	Homo sapiens
140740	Mus musculus
309858	Rattus norvegicus
436861	Danio rerio
495416	Xenopus laevis
421774	Gallus gallus
475016	Canis lupus familiaris
541040	Bos taurus
100328696	Oryctolagus cuniculus
100728680	Cavia porcellus
100152304	Sus scrofa
100072096	Equus caballus

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