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one additional protein, namely P58 (zeige CDK11B Proteine)(IPK), specifically precipitated with Akita proinsulin (zeige INS Proteine) and approximately ten fold more PDIA6, but not other PDI (zeige PDIA3 Proteine) family members, was bound to Akita proinsulin (zeige INS Proteine). The latter suggests that PDIA6 may act as a key reductase
these findings demonstrated that ER Ca2 (zeige CA2 Proteine)+, PDIA6, IRE1alpha (zeige ERN1 Proteine), and miR (zeige MLXIP Proteine)-322 function in a dynamic feedback loop modulating the UPR under conditions of disrupted ER Ca2 (zeige CA2 Proteine)+ homeostasis.
By facilitating disulfide bond formation, and enhanced ER protein folding, PDIA6 may contribute to the protective effects of ATF6 (zeige ATF6 Proteine) in the ischemic mouse heart.
Results indicate that protein disulfide isomerase family 6 (PDIA6) overexpression promoted the proliferation of HeLa cells by suppressing the phosphorylation of beta-catenin, thereby inhibiting the degradation of beta-catenin through the ubiquitin-proteasome pathway.
the chaperone 78-kDa glucose-regulated protein (GRP78 (zeige HSPA5 Proteine)) protects the MPD (zeige MVD Proteine) against PDI (zeige PADI1 Proteine)-dependent disulfide-bond isomerization by binding to this domain and, thereby, preventing ADAM17 (zeige ADAM17 Proteine) inhibition.
Downregulation of PDIA6 inhibited BC cell proliferation and invasion in vitro as well as tumor growth and metastasis in vivo. In addition, PDIA6 downregulation suppressed the Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling pathway.
Results indicate that re-expression of miR (zeige MLXIP Proteine)-127-3p and miR (zeige MLXIP Proteine)-376a-3p induces a strong tumor suppressor effect in GCTSC, which is partially mediated via COA1 (zeige UBXN11 Proteine) and PDIA6.
ACE (zeige ACE Proteine) and PDIA6 were identified as potential HSPA2 (zeige HSPA2 Proteine)-interacting proteins; this assemblage resides in membrane raft microdomains located in the peri (zeige PLIN1 Proteine)-acrosomal region of the sperm head.
Restoration of miR (zeige MLXIP Proteine)-127-3p and miR (zeige MLXIP Proteine)-376a-3p counteracts the neoplastic phenotype of giant cell tumor of bone derived stromal cells by targeting COA1 (zeige UBXN11 Proteine), GLE1 (zeige GLE1 Proteine) and PDIA6.
PDIA3 (zeige PDIA3 Proteine) and PDIA6 gene expression is a neoplasm aggressiveness marker in primary ductal breast cancer.
CDDP-resistant non-small lung cancer cells undergo profound remodeling of their endoplasmic reticulum (ER) proteome (>80 proteins identified by proteomics) and exhibit a dramatic overexpression of two protein disulfide isomerases, PDIA4 and PDIA6.
Txnip (zeige TXNIP Proteine) is located in the endoplasmic reticulum and interacts with endogenous PDIA6. Txnip (zeige TXNIP Proteine) increases PDI (zeige PADI1 Proteine) activity.
levels of expression of ERp5 and GRP78 (zeige HSPA5 Proteine) correlated with the level of expression of membrane-bound MICA (zeige MICA Proteine) in chronic lymphocytic leukemia patients.
Protein disulfide isomerases (EC 22.214.171.124), such as PDIA6, are endoplasmic reticulum (ER) resident proteins that catalyze formation, reduction, and isomerization of disulfide bonds in proteins and are thought to play a role in folding of disulfide-bonded proteins (Hayano and Kikuchi, 1995
protein disulfide isomerase-related protein
, protein disulfide-isomerase A6
, thioredoxin domain containing 7
, thioredoxin domain-containing protein 7
, ER protein 5
, endoplasmic reticulum protein 5
, protein disulfide isomerase P5
, protein disulfide isomerase-associated 6
, thioredoxin domain containing 7 (protein disulfide isomerase)
, calcium-binding protein 1
, protein disulfide isomerase A6
, protein disulfide isomerase associated 6