The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 also can affect the central nervous system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009].
Aktuelle Publikationen für unsere Endothelin 1 Proteine
Schildroth, Rettig-Zimmermann, Kalk, Steege, Fähling, Sendeski, Paliege, Lai, Bachmann, Persson, Hocher, Patzak: "Endothelin type A and B receptors in the control of afferent and efferent arterioles in mice." in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, Vol. 26, Issue 3, pp. 779-89, (2011) (PubMed).
Inoue, Yanagisawa, Takuwa, Mitsui, Kobayashi, Masaki: "The human preproendothelin-1 gene. Complete nucleotide sequence and regulation of expression." in: The Journal of biological chemistry, Vol. 264, Issue 25, pp. 14954-9, (1989) (PubMed).
Bloch, Friedrich, Lee, Eddy, Shows, Quertermous: "Structural organization and chromosomal assignment of the gene encoding endothelin." in: The Journal of biological chemistry, Vol. 264, Issue 18, pp. 10851-7, (1989) (PubMed).
Itoh, Yanagisawa, Ohkubo, Kimura, Kosaka, Inoue, Ishida, Mitsui, Onda, Fujino: "Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin." in: FEBS letters, Vol. 231, Issue 2, pp. 440-4, (1988) (PubMed).