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Human Monoclonal TGFb Primary Antibody für - ABIN577154
Nishiyama, McDonough, Bruns, Burgeson: Type XII and XIV collagens mediate interactions between banded collagen fibers in vitro and may modulate extracellular matrix deformability. in The Journal of biological chemistry 1994
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Human Monoclonal TGFb Primary Antibody für FACS, IHC - ABIN6664767
Chen, Ren, Zhang, Sun, Wang, Li, Zhang, Zhao: Disorganized vascular structures in sporadic venous malformations: a possible correlation with balancing effect between Tie2 and TGF-β. in Scientific reports 2016
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Mouse (Murine) Monoclonal TGFb Primary Antibody für FACS, IHC - ABIN3020892
Xia, Ren, Zhu, Yu, Zhang, Sun, Zhao, Chen: Downregulation of miR-145 in venous malformations: Its association with disorganized vessels and sclerotherapy. in European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2017
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Human Polyclonal TGFb Primary Antibody für IHC (p), ELISA - ABIN2476753
Goldraich, Ramos, Goldraich: Urography versus DMSA scan in children with vesicoureteric reflux. in Pediatric nephrology (Berlin, Germany) 1990
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Cow (Bovine) Monoclonal TGFb Primary Antibody für ELISA, FACS - ABIN2476751
Mahan, Ballal, Nanda: Mitral valve tear complicating percutaneous valvuloplasty: diagnosis by transesophageal Doppler color flow mapping. in American heart journal 1991
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TGF-beta 1/CTGF based on the p38 MAPK signaling pathway play an important role in the occurance and development of hypertrophy of human lumbar ligamentum flavum.
TGFbeta1 protects colorectal tumor cells from stressinduced apoptosis through repressing basal and stressinduced XAF1 gene transcription levels and activation of RAS-ERK signaling.
High serum TGFB1 expression is associated with drug resistance in breast cancer.
Low TGFB1 expression is associated with pre-eclampsia.
In children of early age with pielonefritis on the background of vesicoureteral reflux and the presence of genotype C-509capital ES, Cyrillic and T+869capital TE, Cyrillic (65,02+/-6,74%) transforming growth factor beta1 (TGF beta1) gene the probability of developing the disease is 4.48 times higher, compared to genotype of T-509capital TE, Cyrillic+869capital ES, Cyrillic and 3.03 times higher compared to genotype S-5...
TGFbeta1 regulates HGF-induced and MET-mediated cell migration, through positive regulation of C-ets-1 and negative regulation of miR-128-3p expression in basal-like breast cancer cell lines and in triple-negative breast cancer tissue.
our data point at SMYD3 as a pivotal SMAD3 cofactor that promotes TGFbeta-dependent mesenchymal gene expression and cell migration in breast cancer, and support SMYD3 as a promising pharmacological target for anti-cancer therapy.
TGFB1 alleles and specific genotypes, and 4-locus TGFB1 haplotypes influence BC susceptibility.
The aim of our study was to evaluate the changes of Advanced Glycation End Products, ERK1/2, and TGFB/Smad proteins expression in the muscularis propria of the anterior vaginal wall of patients affected from Pelvic Organ Prolapse compared with controls.
Serum MCP-1 and TGF-beta1 levels increased in polymyositis/dermatomyositis patients.
BAY 41-2272 significantly reduced TGF-b induced fibroblast proliferation, but did not reduce viability. This inhibitory effect was further supported by forskolin. Both BAY 41-2272 and forskolin alone reduced TGF-beta induced collagen and fibronectin de novo synthesis as well as deposition.
Here, the authors show that TGF-beta-induced SMAD1/5 phosphorylation requires members of two classes of type I receptor, TGFBR1 and ACVR1, and establish a new paradigm for receptor activation where TGFBR1 phosphorylates and activates ACVR1, which phosphorylates SMAD1/5.
TGF-beta1 and lncRNA-ATB expression was upregulated in patients with atherosclerosis, and increased expression levels of TGF-beta1 and lncRNA-ATB may be used to effectively distinguish atherosclerosis patients from normal healthy individuals.
this study shows higher peritoneum and serum levels of TGF-beta1 in women with endometriosis
TGFbeta1 signalling could induce the proliferation.
Our results point to a defect in the TGF-beta1 signaling pathway in T cells of patients with active systemic lupus erythematosus away from remission periods.
LncRNA HAND2-AS1 inhibits non-small cell lung cancer migration, invasion and maintains cell stemness through the interactions with TGFB1.
Lupus Nephritis (LN) patients had significant lower values of serum TGF-beta1 compared with non-LN patients; the values further decreased with more damage of kidney tissues and progression of systemic lupus erythematosus activity.
LncRNA POU3F3 overexpression led to down-regulated TGF-beta1 expression, while exogenous TGF-b1 and TGF-b1 inhibitor treatment did not significantly change the expression level of lncRNA POU3F3. Therefore, lncRNA POU3F3 may promote cancer cell migration and invasion in nasopharyngeal carcinoma by up-regulating TGF-b1
Meta-analysis shows that the polymorphism with homozygote TT and heterozygote C/T of TGF-beta 509C/T (rs1800469) is significantly associated with the increased risk of myocardial infarction.
These data support the contention that FGF2 and TGFB1 modulate THBS1 via miR-221.
TGF-beta1 stimulated lubricin secretion by superficial zone chondrocytes at all densities with twice-a-week TGF-beta treatment. It is noteworthy that the daily treatment of TGF-beta1 increased lubricin much higher compared with twice-a-week treatment.
hypoxia increased the expression of platelet-derived growth factor (PDGF) and transforming growth factor-beta1 (TGF-beta1) and decreased the expression of neprilysin (NEP), which contributed to the hypoxia-induced Endothelial-to-mesenchymal transition of pulmonary artery endothelial cells.
TGF-beta1 modulates the expression of syndecan-4 in cultured vascular endothelial cells in a biphasic manner.
Taken together, Staphylococcus aureus induces TGF-beta1 and bFGF expression through the activation of AP-1 and NF-kappaB in bovine mammary gland fibroblasts.
localized to maternal septum in the interdigitation area of cotyledonary villi and caruncle
The results identify TGFB1 and ESRRA as likely transcriptional regulators of rumen epithelial development and energy metabolism, respectively, and provide targets for modulation of rumen development and function in the growing calf.
the combined treatment with TGF-beta1 and BMP-7 or treatment first with TGF-beta1 followed by BMP-7 was more effective than other treatment groups in both chondrogenic differentiation and SZP secretion.
Tenascin-X promotes activation of latent TGF-beta1 and subsequent epithelial to mesenchymal transition in mammary epithelial cells.
a detailed computational model for TGF-beta signalling that incorporates elements of previous models together with crosstalking between Smad1/5/8 and Smad2/3 channels through a negative feedback loop dependent on Smad7.
Endogenous TGF-beta1 became more bioactive following activation of the transgene protein product in chondrocytes.
A novel peptide, P2K, regulating TGF-beta1 signaling had an anabolic effect on bovine intervertebral disc cells and rabbit degenerated discs.
Data show that TGF-beta pathways operate during ovarian fetal development, and fibrillin 3 is highly expressed at a critical stage early in developing human and bovine fetal ovaries.
Role of TGF-beta1 and TNF-alpha in IL-1beta mediated activation of proMMP-9 in pulmonary artery smooth muscle cells: involvement of an aprotinin sensitive protease.
Immunohistochemistry in rectus abdominis muscle from foetuses at 180 and 260 days post-conception
vascular endothelial growth factor indirectly stimulates smooth muscle cell proliferation and migration through the modulation of basic fibroblast growth factor and transforming growth factor beta(1) released by endothelial cells
Data show that as antral follicles develop, transforming growth factor (TGF)-beta3 is the most abundant TGF-beta isoform and TGF-beta1 protein levels decline in large follicles.
TGF-beta 1 signaling pathway controls pericyte growth state and contractile phenotype
Reactive oxygen species mediate TGF-beta1-induced TIMP-3 gene expression
MGP plays a role in endothelial cell function, by increasing transforming growth factor-beta1 activity and stimulating VEGF expression
TGFB1overexpressing bone marrowderived mesenchymal stem cells promoted new bone formation in the rabbit femoral defect model.
Data indicate that cardiac contractility modulation (CCM) therapy exerted protective effects against myocardial fibrosis potentially by inhibiting TGF-beta1/Smad3 signaling pathway in chronic heart failure .
Studied effects of panax notoginseng saponins on the differentiation of mesenchymal stem cells using gene silencing of TGF-B1 signal pathway.
study suggested that TGF-beta1/Smad3/smad7 is a major pathway which plays an important role in the regulation of the IUA and specific inhibitor of Smad3 (SIS3) may provide a new therapeutic strategy for IUA.
cell therapy promoted TGF-beta1 expression in nucleus pulposus, leading to anti-inflammatory effects via the inhibition of NF-kappaB, and the amelioration of disc degradation.
that prenatal tracheal occlusion increases TGF-beta/Rho kinase pathway, myofibroblast differentiation, and matrix deposition in neonatal rabbit and human congenital diaphragmatic hernia lungs
observation. Based on the above results, we conclude that TGF-beta1-immobilized PLGA-gelatin scaffold seeded with ASCs considerably enhances the quality of the tissue-engineered cartilage, therefore, advancing the field of cartilage tissue engineering
Smad7 plays a crucial role in antagonizing epithelial-mesenchymal transition induced by TGFbeta signaling and is a Notch signaling target in limbal epithelial stem cells.
the role of IL-10 in inhibited allograft rejection may be associated with CD4+CD25+ regulatory T cells and IL-10, and may be independent of TGF-b
After NOTCH1 knockdown and TGFB1 stimulation, rabbit mesenchymal stem cells expressed higher levels of proteoglycan and collagen II.
Adverse biventricular remodeling in isolated right ventricular hypertension is mediated by increased transforming growth factor-beta1 signaling.
TGF-beta1 gene transcription significantly correlates with the surgical vaginal and dermal wound closure rate.
Wound closure was significantly protracted (P < 0.02), whereas TGFbeta1 gene expression was significantly increased (P < 0.0001) during the wound healing process in oophorectomised rabbits.
Radix astragali injection inhibits fibroblast proliferation in hypertrophic scars through down-regulating mRNA expression and protein synthesis of TGF-beta and Smad3.
Report established neointimal hyperplasia in vein grafts expands via TGF-beta1 (TGFB1)-mediated progressive fibrosis.
Thrombomodulin downregulation in vein gafts is mediated by paracrine release of TGF-beta1 caused by pressure-induced vessel stretch.
Angiotensin-(1-7) attenuates postangioplasty collagen synthesis in rabbits possibly through down-regulating the expression of TGF-beta1 and inhibiting the activation of Smad2 pathway.
TGF-beta1 may not be the primary mediator of muscle fibrosis in distraction osteogenesis
Glucosamine hydrochloride treatment can can partially decrease the expression levels of IL-1 beta and increase the expression levels of TGF-beta 1, which delays the development of osteoarthritis.
TGF beta is involved in the pathogenesis of tympanosclerosis.
There was significantly higher expression of TGF-beta1 and MMP-9 in nasal mucosa of experimental allergic rhinitis guinea pigs than in controls.
TGFB1 can inhibit Salmonella replication whereas TRP53 can promote Salmonella replication in porcine peripheral blood mononuclear cells and murine macrophages.
TGF-beta1 is activated or inactivated by MMP20 or KLK4 and that the amelogenin cleavage product is necessary for the in-solution mobility of TGF-beta1.
Activated TGF-beta signaling rescued miR-143-reduced FSHR and intracellular signaling molecules, and miR-143-induced porcine granulosa cell apoptosis.
TGF-beta1-induced epithelial-myofibroblast plasticity is FAK- dependent, whereas TGF-beta1-induced apoptosis is favored when FAK signaling is inhibited.
this study shows that TGF-beta1 protects intestinal integrity and influences Smad and MAPK signal pathways in intestinal epithelium cells after TNF-alpha challenge
this study shows that anemonin may ameliorate LPS-induced intestinal injury and improve restoration by regulating the TGF-b1 and EGFR signaling pathways
The results indicated that TGF-beta-1 was associated with the restoration of intestinal morphology and barrier function following weaning stress.
Data (including data from in vitro and in vivo experiments) suggest that day 14 elongated conceptus secretes proteins that up-regulate TGFbeta1 mRNA and TGFbeta1 expression in endometrium; TGFbeta1 may be important during pregnancy maintenance.
The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1, IL-10, and IL-6 in ovarian follicles are reported.
Dietary (1,3/1,6)-beta-D-glucan reduced the mRNA expression of transforming growth factor (TGF) beta2 and tended to reduce the mRNA expression of TGF-beta1 in lung tissue of neonatal piglet.
TGF-beta1, via TGF-beta1 receptor I and p38 MAPK signaling, reduces CFTR expression to impair CFTR-mediated anion secretion, which would likely compound the effects associated with mild CFTR mutations and ultimately would compromise male fertility.
High yield isolation of BMP-2 from bone and in vivo activity of a combination of BMP-2/TGF-beta1.
Boar seminal plasma contained TGF- beta1 and IL-10 but with high individual variation.
The present study was aimed to determine the association between metalloproteinase 3 (MMP3), transforming growth factor beta 1 (TGFbeta1) and collagen type X alpha I (COL10A1) gene polymorphisms with traits related to leg weakness in pigs.
Inhibition of transforming growth factor beta-1 augments liver regeneration after partial portal vein ligation in a porcine experimental model.
TGF-beta prevents excessive heart valve growth under normal physiological conditions while it promotes cell proliferation in the early stages of repair.
Crystals of dimeric porcine proTGF-beta1 reveal a ring-shaped complex, a novel fold for the prodomain, and show how the prodomain shields the growth factor from recognition by receptors and alters its conformation.
The effects of different polymorphisms of TGF-beta1 on litter size in Large white pigs are reported.
TGF-beta disrupts an IGF-II-stimulated autocrine amplification cascade that is necessary for muscle differentiation in vitro.
beta-Catenin plays a critical role in mediating TGF-beta1-induced myofibroblast differentiation in aortic valve interstitial cells.
The downregulation of miRNA30e induced the protein expression of Snai1, transforming growth factor (TGF)beta and mothers against decapentaplegic homolog 2 (Smad2) and suppressed that of NADPH oxidase 4 (Nox4) in vitro.
TGF-beta1 modulates Cx43 through nuclear translocation of Smads and resultant binding to the promoter of Cx43.
Genome-wide experiments demonstrate that the proneural factor ASCL1 assists SMAD3 in the binding to a subset of enhancers. Once located at the enhancers, SMAD3 recruits the histone demethylase JMJD3 and the remodeling factor CHD8, creating the appropriate chromatin landscape to allow enhancer transcription and posterior gene activation
TGFbeta1-induced expression of caldesmon mediates epithelial-mesenchymal transition.
In the present study, the favorable role of hesperetin extracted from citrus peels was verified to prevent the progression of BDL-induced liver fibrosis via inhibiting TGF-beta1/Smad pathway-mediated extracellular matrix progression and apoptosis.
these data show that ablating PITPs in MKs indirectly dysregulates hematopoiesis in the BM by disrupting alpha-granule physiology and secretion of TGF-beta1.
NEDD4 enhances osteoblast proliferation by removing pSMAD1 activated by TGFbeta1.
increase the understanding of Tgfbeta1-mediated effects in microglia and place emphasis on the importance of Tgfbeta1 for microglia maturation and maintenance
The aim of this study was to identify novel candidate genes implicated in chondrocyte hypertrophy during osteoarthritis (OA) pathogenesis by determining which TGFbeta-related genes are regulated during murine OA and endochondral ossification.
elevated levels of active TGF-beta in the enthesis bone marrow induce the initial pathological changes of enthesopathy
High TGFB1 expression is associated with cognitive impairment.
TGF-beta1-induced deposition of provisional extracellular matrix by tracheal basal cells promotes epithelial-to-mesenchymal transition in a c-Jun NH2-terminal kinase-1-dependent manner.
this study shows that age-related loss of innate immune antimicrobial function of dermal fat is mediated by TGF-beta
that Raf1-promoted TGF-beta1 signaling was through the Raf1/ERK/Smad pathway and contributed to the cell proliferation and migration
These results highlight the multifunctional impact of TGFbeta on pulmonary pathology in vivo and identify cellular-response differences that may impact Cystic fibrosis lung pathology.
In summary, the authors concluded that glycosylation-dependent Gal-1/NRP-1 interactions activate TGF-beta and PDGF-like signaling to promote the migration and activation of hepatic stellate cells.
Irradiation induced SMAD-dependent TGFbeta signaling independently of the PPARalpha status, but the presence of PPARalpha was necessary for the activation of the SMAD-independent pathway.
TGF-beta is involved in the pathogenesis of acute liver injury.Plasma kallikrein-dependent activation of latent TGF-beta.
this study shows that TGF-beta suppresses RasGRP1 expression and supports regulatory T cell resistance against p53-induced CD28-dependent T-cell apoptosis
LRRC25 as a critical molecular switch whose down-regulation resulted in cardiac hypertrophy in a TGF-beta1- and NF-kappaB-dependent manner.
This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.
TGF-beta 1 protein
, latency-associated peptide
, transforming growth factor beta-1
, transforming growth factor, beta 1 (Camurati-Engelmann disease)
, transforming growth factor-beta 1
, transforming growth factor beta 1
, transforming growth factor-beta
, transforming growth factor beta1
, transforming growth factor-beta-1
, TGF-beta 1
, regulatory protein
, transforming growth factor, beta-1