anti-SH3-Domain Kinase Binding Protein 1 (SH3KBP1) Antikörper

Bezeichnung:: anti-SH3-Domain Kinase Binding Protein 1 Antikörper (SH3KBP1)

Auf www.antikoerper-online.de finden Sie aktuell 47 SH3-Domain Kinase Binding Protein 1 (SH3KBP1) Antikörper von 14 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen SH3-Domain Kinase Binding Protein 1 Proteine (9) und und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 61 SH3-Domain Kinase Binding Protein 1 Produkte verfügbar.

Synonyme:: 1200007H22Rik, 1700125L08Rik, 5830464D22Rik, AI447724, CD2BP3, CIN85, GIG10, HSB-1, HSB1, IN85, MIG18, Ruk, Seta

Alle Antikörper anzeigen	Gen	GeneID	UniProt
	SH3KBP1	30011	Q96B97
	SH3KBP1	58194	Q8R550
	SH3KBP1	84357	Q925Q9
Alle Spezies anzeigen Weitere Synonyme anzeigen

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Human SH3-Domain Kinase Binding Protein 1 (SH3KBP1) Interaktionspartner

Transcriptional regulation of NOX genes expression in human breast adenocarcinoma cells is modulated by adaptor protein CIN85.
The multiple Src (zeige SRC Antikörper) homology 3 (SH3) domains of trimeric CIN85 molecules associated with multiple SLP-65 (zeige BLNK Antikörper) molecules, which recruited further CIN85 trimers, thereby perpetuating the oligomerization process.
these data support a role for the novel PP2Ac (zeige PPP2CA Antikörper)-CIN85 complex in supporting integrin-dependent platelet function by dampening the phosphatase activity.
CIN85 promotes recycling of TGF-beta (zeige TGFB1 Antikörper) receptors and thereby positively regulates TGF-beta (zeige TGFB1 Antikörper) signaling.
we demonstrate that SEPT9 (zeige SEPT9 Antikörper) negatively regulates EGFR (zeige EGFR Antikörper) degradation by preventing the association of the ubiquitin ligase Cbl (zeige CBL Antikörper) with CIN85, resulting in reduced EGFR (zeige EGFR Antikörper) ubiquitylation
Results support the model that Cbl (zeige CBL Antikörper)-CIN85-endophilin complex is not required for efficient internalization of EGFR (zeige EGFR Antikörper), a prototype RTK.
Multiple molecular forms of adaptor protein Ruk/CIN85 specifically associate with different subcellular compartments in human breast adenocarcinoma cell line.
LOX (zeige LOX Antikörper)-PP interacts with CIN85 via a novel SH3-binding motif and this association reduces CIN85-promoted invasion by breast cancer cells.
an FRS2beta (zeige FRS3 Antikörper)-CIN85/CD2AP (zeige Cd2ap Antikörper)-Cbl (zeige CBL Antikörper) axis for downregulation of ErbB2 (zeige ERBB2 Antikörper) may regulate ErbB2 (zeige ERBB2 Antikörper) protein levels in physiological and pathological settings
Data show that EGFR (zeige EGFR Antikörper) activation leads to a pronounced src (zeige SRC Antikörper)-mediated tyrosine phosphorylation of CIN85 that subsequently influences EGFR (zeige EGFR Antikörper) ubiquitination.

Mouse (Murine) SH3-Domain Kinase Binding Protein 1 (SH3KBP1) Interaktionspartner

Cin85-deficient mother mice had reduced pituitary hormone (zeige CGA Antikörper) prolactin (zeige PRL Antikörper) secretion as a result of excessive dopamine signaling in the brain. Their offspring matured normally and produced their own pups; however, nurturing behaviors such as pup retrieval and nursing were strongly inhibited.
competitive analytical gel-filtration chromatography and isothermal titration calorimetry (ITC) results showed that ARAP1 (zeige ARAP1 Antikörper) could compete with Cbl (zeige CBL Antikörper) for CIN85 binding, which provides a biochemical basis for the regulatory roles of ARAP1 (zeige ARAP1 Antikörper) in the CIN85-mediated EGFR (zeige EGFR Antikörper) internalizing process.
CIN85/RukL is involved in endocytosis of nephrin (zeige NPHS1 Antikörper) in podocytes under diabetic conditions, causing podocyte depletion and promoting proteinuria. CIN85/RukL expression therefore shows potential to be a novel target for antiproteinuric therapy in diabetes.
Dab1 (zeige DAB1 Antikörper) mediated the association of CIN85 with ApoER2 (zeige LRP8 Antikörper) or VLDLR (zeige VLDLR Antikörper) in neurons.
Data suggest that Ser587 Cin85 phosphomimetic mutant protein shows dramatically reduced binding to Dab1 (zeige DAB1 Antikörper) (disabled protein 1) (without affecting binding to CapZ (zeige CAPZA1 Antikörper)).
Sh3kbp1 is SUMOylated by SUMO-1 (zeige SUMO1 Antikörper), -2, and -3 and that SUMOylation is enhanced in the presence of Cd2ap (zeige Cd2ap Antikörper).
the interaction between SHIP-1 (zeige INPP5D Antikörper) and CIN85 might synergistically facilitate the down-regulation of phosphatidylinositol-3,4,5-trisphosphate levels.
Live cell imaging and co-immunoprecipitation experiments confirmed that both SLP65 (zeige BLNK Antikörper) and CIN85 are both required for the onset and progression phases of B-cell antigen receptor signal transduction.
a B cell-specific deletion of CIN85 led to impaired T cell-independent type II antibody responses in vivo and diminished IKK-beta (zeige IKBKB Antikörper) activation and cellular responses to B (zeige TDO2 Antikörper) cell receptor cross-linking in vitro
Coexpression of CIN85/Ruk(L) with CD2AP (zeige Cd2ap Antikörper) led to a decreased binding of CIN85/Ruk(L) to nephrin (zeige NPHS1 Antikörper) and podocin, which indicates a functional competition between CD2AP (zeige Cd2ap Antikörper) and CIN85/Ruk(L).

SH3-Domain Kinase Binding Protein 1 (SH3KBP1) Antigen-Profil

Beschreibung des Gens

This gene encodes an adapter protein that contains three N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The encoded protein facilitates protein-protein interactions and has been implicated in numerous cellular processes including apoptosis, cytoskeletal rearrangement, cell adhesion and in the regulation of clathrin-dependent endocytosis. Alternate splicing results in multiple transcript variants.

Alternative names and synonyms associated with SH3-Domain Kinase Binding Protein 1 (SH3KBP1)

SH3 domain containing kinase binding protein 1 (SH3KBP1) Antikörper
SH3-domain kinase binding protein 1 (sh3kbp1) Antikörper
SH3 domain-containing kinase-binding protein 1 (LOC100551401) Antikörper
SH3-domain kinase binding protein 1 (Sh3kbp1) Antikörper
SH3 domain-containing kinase-binding protein 1 (Sh3kbp1) Antikörper

1200007H22Rik Antikörper
1700125L08Rik Antikörper
5830464D22Rik Antikörper
AI447724 Antikörper
CD2BP3 Antikörper
CIN85 Antikörper
GIG10 Antikörper
HSB-1 Antikörper
HSB1 Antikörper
IN85 Antikörper
MIG18 Antikörper
Ruk Antikörper
Seta Antikörper

Bezeichner auf Proteinebene für SH3KBP1

SH3-domain kinase binding protein 1 , SH3 domain-containing kinase-binding protein 1-like , CD2-binding protein 3 , SH3 domain-containing kinase-binding protein 1 , Src family kinase-binding protein 1 , c-Cbl-interacting protein , cbl-interacting protein of 85 kDa , human Src family kinase-binding protein 1 , migration-inducing gene 18 , src-related kinase binding protein-1 , SH3-containing, expressed in tumorigenic astrocytes , Sh3 containing, expressed in astrocytes , regulator of ubiquitous kinase , SH3 domain-containing adapter protein , ruk

GENE ID	SPEZIES
465527	Pan troglodytes
612797	Canis lupus familiaris
100013895	Monodelphis domestica
100058644	Equus caballus
100151706	Xenopus (Silurana) tropicalis
100357864	Oryctolagus cuniculus
100450340	Pongo abelii
100471577	Ailuropoda melanoleuca
694764	Macaca mulatta
100083478	Ornithorhynchus anatinus
100522530	Sus scrofa
100551401	Meleagris gallopavo
30011	Homo sapiens
58194	Mus musculus
84357	Rattus norvegicus
418608	Gallus gallus
510489	Bos taurus

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