This gene encodes a precursor protein that is cleaved into two products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiation factor functions as a cytokine that can stimulate colony formation in bone marrow megakaryocytes. Mesothelian is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010].
MSLN
Spezies: Human
Wirt: HEK-293 Cells
Recombinant
The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
WB
custom-made
MSLN
Spezies: Maus
Wirt: HEK-293 Cells
Recombinant
> 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
custom-made
MSLN
Spezies: Human
Wirt: HEK-293 Cells
Recombinant
> 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
MSLN
Spezies: Human
Wirt: HEK-293 Cells
Recombinant
The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
MSLN
Spezies: Maus
Wirt: HEK-293 Cells
Recombinant
The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
Aktuelle Publikationen für unsere Mesothelin Proteine
Li, Li, Xu, Xing, Ding, Jing, Wang, Hong: "Preclinical evaluation of a novel anti-mesothelin immunotoxin based on a single domain antibody as the targeting ligand." in: International journal of pharmaceutics, Vol. 602, pp. 120647, (2021) (PubMed).
Sirois, Deny, Li, Fall, Moore: "Engineered Fn3 protein has targeted therapeutic effect on mesothelin-expressing cancer cells and increases tumor cell sensitivity to chemotherapy." in: Biotechnology and bioengineering, (2019) (PubMed).
Sirois, Deny, Baierl, George, Moore: "Fn3 proteins engineered to recognize tumor biomarker mesothelin internalize upon binding." in: PLoS ONE, Vol. 13, Issue 5, pp. e0197029, (2018) (PubMed).
Chang, Chen, Chen, Chiang, Chen, Mao, Lin, Lin Chiang, Cheng: "Mesothelin enhances invasion of ovarian cancer by inducing MMP-7 through MAPK/ERK and JNK pathways." in: The Biochemical journal, Vol. 442, Issue 2, pp. 293-302, (2012) (PubMed).
Li, Bharadwaj, Zhang, Zhang, Mu, Fisher, Brunicardi, Chen, Yao: "Mesothelin is a malignant factor and therapeutic vaccine target for pancreatic cancer." in: Molecular cancer therapeutics, Vol. 7, Issue 2, pp. 286-96, (2008) (PubMed).