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TH is a robust interaction partner of different 14-3-3 (zeige YWHAQ Proteine) dimer types with moderate variability between the 14-3-3 (zeige YWHAQ Proteine) dimers on their regulation of TH.
Retinol activates tyrosine hydroxylase via two sequential non-genomic mechanisms, which have not previously been characterized. These mechanisms are likely to operate in vivo to facilitate the stress response.
IFN-alpha (zeige IFNA Proteine) mediated activation of ERK1/2 appeared to be responsible for the increased phosphorylation of tyrosine hydroxylase.
This study demonstrated that the expression patterns of the calcitonin-related polypeptide alpha (zeige CALCA Proteine) and tyrosine hydroxylase formed opposing gradients, with tyrosine hydroxylase being preferentially expressed in apical and calcitonin-related polypeptide alpha (zeige CALCA Proteine) in basal type II afferent neurons, indicating heterogeneity among type II afferent neurons.
Study used Cre-lox (zeige LOX Proteine) technology to selectively ablate tyrosine hydroxylase (TH) from Kiss1 (zeige KISS1 Proteine) cells. Surprisingly, despite a practically complete knock-out of TH from Kiss1 (zeige KISS1 Proteine) cells, study found that all aspects of puberty, reproductive hormone secretion, and fertility were normal in Kiss THKOs. This suggests that dopamine synthesized in Kiss1 (zeige KISS1 Proteine) cells is not required for normal puberty and reproduction.
These findings reveal that Th and Gad1 share a transcription regulatory mechanism that facilitates odorant-dependent regulation of dopamine and GABA expression levels.
deletion of Th in hematopoietic cells of adult mice neither alters energy expenditure upon cold exposure nor reduces browning in inguinal adipose tissue. Bone marrow-derived macrophages did not release NE in response to stimulation with IL-4 (zeige IL4 Proteine), and conditioned media from IL-4 (zeige IL4 Proteine)-stimulated macrophages failed to induce expression of thermogenic genes, such as uncoupling protein 1 (Ucp1 (zeige UCP1 Proteine)), in adipocytes.
The neurogenic contractions were higher in the sickle cell disease, in association with elevated tyrosine hydroxylase phosphorylated at Ser (zeige SIGLEC1 Proteine)-31 and total tyrosine hydroxylase protein expression, as well as increased tyrosine hydroxylase mRNA expression.
these data demonstrate a novel interaction between Hsc70 (zeige HSPA8 Proteine) and TH that regulates the activity and localization of the enzyme to synaptic vesicles, suggesting an important role for Hsc70 (zeige HSPA8 Proteine) in dopamine homeostasis.
TH gene overexpression promotes the polarization and differentiation of CD4 (zeige CD4 Proteine)+ cells towards Th2 cells.
The TH-immunopositive fibres detected in the orbitofrontal cortices of the DISC1 (zeige DISC1 Proteine) KO mice were significantly shorter than those seen in the wild-type mice.
Real-time PCR analyses revealed that social defeat significantly increased tyrosine hydroxylase in the ventral tegmental area.
These results revealed a new role of the canonical Lrp5 (zeige LRP5 Proteine)/6-beta-catenin (zeige CTNNB1 Proteine) pathway in regulating the morphogenesis of the cerebellum during postnatal development.
Achilles tendon tenocytes produce tyrosine hydroxylase.
One novel mutation of c.679A>G (p.T227A) in GCH1 (zeige GCH1 Proteine) and 3 known mutations of c.457C>T (p.R153X), c.739G>A (p.G247S), and c.698G>A (p.R227H) in tyrosine hydroxylase (TH) have been found and predicted to be damaging or deleterious.
A novel heterozygous variant in tyrosine hydroxylase was identified in Chinese patients with dopa-responsive dystonia.
The purpose of this study is to investigate the clinical significance of tyrosine hydroxylase (TH) expression in peripheral blood (PB) at diagnosis in patients with neuroblastoma (zeige ARHGEF16 Proteine).. The treatment intensity should be tailored according to TH expression in PB at diagnosis.
Results show that the positive rates and expression levels of nestin (zeige NES Proteine), tyrosine hydroxylase (TH), GFAP (zeige GFAP Proteine) and IL-17 (zeige IL17A Proteine) were significantly decreased while Foxp3 (zeige FOXP3 Proteine) and the ratio of Foxp3 (zeige FOXP3 Proteine)/IL-17 (zeige IL17A Proteine) were statistically elevated in BM of AML (zeige RUNX1 Proteine) patients.
Data suggest that TH phosphorylated at Ser (zeige SIGLEC1 Proteine)-31 co-distributes with Golgi complexes and synaptic-like vesicles in rat and human dopaminergic neurons/cell lines; Ser (zeige SIGLEC1 Proteine)-31 phosphorylation may regulate TH subcellular localization by enabling its transport along microtubules, notably toward the projection terminals.
No statistically significant differences were found between cases and controls for the allele frequencies in five genes: TH, SLC18A2, DRD1 (zeige DRD1 Proteine), DRD3 (zeige DRD3 Proteine) and COMT (zeige COMT Proteine). Conversely, some alleles of the 12 sNPs from the DRD2 (zeige DRD2 Proteine) locus and the 5 from the MAOA (zeige MAOA Proteine) locus showed significant associations with excessive alcohol consumption.
Results show that metastasis-associated protein 1 (MTA1 (zeige MTA1 Proteine)) and tyrosine hydroxylase (TH) levels were significantly down-regulated in Parkinson disease (PD) samples as compared with normal brain tissue
the reduction of tyrosine hydroxylase-immunoreactive neurons occurring in the locus coeruleus after perinatal hypoxic insults persists into adulthood
In high-risk metastatic Neuroblastoma (zeige ARHGEF16 Proteine), TH and DCX (zeige DCX Proteine) mRNA quantification could be used for the assessment of response to treatment and for early detection of progressive disease or relapses.
The biochemically conserved regulatory mechanisms of recombinant DTH parallel those from mammals.
maternal as well as embryonic effects on the secretion and/or functionality of Tyrosine hydroxylase (pale) may play roles in the early developmental program of the organism.
activity of tyrosine hydroxylase is also increased by this interaction, in excess (zeige RCC1 Proteine) of the stimulation resulting from phosphorylation alone
Tyrosine hydroxylase is co-localized with egr1 (zeige EGR1 Proteine) in olfactory bulb throughout brain development.
Transiently knocked down tyrosine hydroxylase (TH, the rate limiting enzyme in DA synthesis) gene expression in the early stages of brain development was studied in zebrafish.
Overall, TH1 (zeige TH1L Proteine)+ and serotonergic system innervation is massively altered in the successfully regenerated spinal cord of adult zebrafish.
The tyrosine hydroxylase-immunoreactive cells in zebrafish are limited to very specific subpopulations of the amacrine cells.
mRNA expression of TH1 (zeige TH1L Proteine) and TH2 is differentially affected by hypoxia exposure in larvae and adults. TH1 (zeige TH1L Proteine) mRNA levels are much higher in eye and brain
th1 (zeige TH1L Proteine) is predominant in the brain of zebrafish and th2 in the periphery.
The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
, tyrosine 3-monooxygenase
, tyrosine hydroxylase
, dystonia 14
, XBB70 group VII
, drosophila tyrosine hydroxylase
, tyrosine hydrodroxylase
, tyrosine hydroxylase S homeolog