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Doublecortin Produkte

(Doublecortin (DCX))

Kategorien

This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ('double cortex' syndrome) in females and lissencephaly ('smooth brain' syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010].

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Ausgewählte Doublecortin Kategorien

Doublecortin Antikörper

High quality antibodies with extensive validation data.

Doublecortin ELISA Kits

Reliable ELISA kits for a wide range of species.

Doublecortin Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene Doublecortin Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation WB, ELISA, IHC, ICC, FACS
Validierungen
  • (1)
  • (7)
Kat. Nr. ABIN969513
Menge 0.1 mg
Datenblatt Datenblatt
Reaktivität Human, Mouse, Rat
Applikation WB, ELISA, IHC, IF
Validierungen
  • (5)
Kat. Nr. ABIN625829
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, ELISA, IHC, FACS, IF/ICC
Validierungen
  • (8)
Kat. Nr. ABIN1844030
Menge 100 μL
Datenblatt Datenblatt

Empfohlene Doublecortin ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6955452
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Mouse
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6955453
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Rat
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6955454
Menge 96 tests
Datenblatt Datenblatt

Empfohlene Doublecortin Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
  • (1)
Kat. Nr. ABIN1351244
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Escherichia coli (E. coli)
Validierungen
  • (1)
Kat. Nr. ABIN7122702
Menge 50 μg
Datenblatt Datenblatt
Reaktivität Human
Source Insect Cells
Validierungen
  • (1)
Kat. Nr. ABIN3078822
Menge 1 mg
Datenblatt Datenblatt

Neueste Publikationen zu unseren Doublecortin Produkten

Zhang, Zhao, Zhang, Xu, Lian, Wu, He, Sun, Li: "Regulation of the p75 neurotrophin receptor attenuates neuroinflammation and stimulates hippocampal neurogenesis in experimental Streptococcus pneumoniae meningitis." in: Journal of neuroinflammation, Vol. 18, Issue 1, pp. 253, (2022) (PubMed).

Jiang, Brackeva, Stangé, Verhaeghen, Costa, Couillard-Després, Rotheneichner, Aigner, Van Schravendijk, Pipeleers, Ling, Gorus, Martens: "LC-MS/MS identification of doublecortin as abundant beta cell-selective protein discharged by damaged beta cells in vitro." in: Journal of proteomics, Vol. 80, pp. 268-80, (2013) (PubMed).

Klempin, Kronenberg, Cheung, Kettenmann, Kempermann: "Properties of doublecortin-(DCX)-expressing cells in the piriform cortex compared to the neurogenic dentate gyrus of adult mice." in: PLoS ONE, Vol. 6, Issue 10, pp. e25760, (2011) (PubMed).

Zhang, Du, Yang, Wang, Yu, Huang, Hu, Liu, Fu: "Granulocyte colony-stimulating factor increases the therapeutic efficacy of bone marrow mononuclear cell transplantation in cerebral ischemia in mice." in: BMC neuroscience, Vol. 12, pp. 61, (2011) (PubMed).

Evangelisti, Florian, Massimi, Dominici, Giannini, Galardi, Buè, Massalini, McDowell, Messi, Gulino, Farace, Ciafrè: "MiR-128 up-regulation inhibits Reelin and DCX expression and reduces neuroblastoma cell motility and invasiveness." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 23, Issue 12, pp. 4276-87, (2009) (PubMed).

Leger, Souville, Boddaert, Elie, Pinard, Plouin, Moutard, des Portes, Van Esch, Joriot, Renard, Chelly, Francis, Beldjord, Bahi-Buisson: "The location of DCX mutations predicts malformation severity in X-linked lissencephaly." in: Neurogenetics, Vol. 9, Issue 4, pp. 277-85, (2008) (PubMed).

Zhang, Ryan, Di Cesare, Liu, Walsh, You: "Doublecortin is expressed in articular chondrocytes." in: Biochemical and biophysical research communications, Vol. 363, Issue 3, pp. 694-700, (2007) (PubMed).

Magavi, Leavitt, Macklis: "Induction of neurogenesis in the neocortex of adult mice." in: Nature, Vol. 405, Issue 6789, pp. 951-5, (2000) (PubMed).

des Portes, Pinard, Billuart, Vinet, Koulakoff, Carrié, Gelot, Dupuis, Motte, Berwald-Netter, Catala, Kahn, Beldjord, Chelly: "A novel CNS gene required for neuronal migration and involved in X-linked subcortical laminar heterotopia and lissencephaly syndrome." in: Cell, Vol. 92, Issue 1, pp. 51-61, (1998) (PubMed).

Gleeson, Allen, Fox, Lamperti, Berkovic, Scheffer, Cooper, Dobyns, Minnerath, Ross, Walsh: "Doublecortin, a brain-specific gene mutated in human X-linked lissencephaly and double cortex syndrome, encodes a putative signaling protein." in: Cell, Vol. 92, Issue 1, pp. 63-72, (1998) (PubMed).

Synonyme und alternative Namen zu Doublecortin

doublecortin (DCX), doublecortin (Dcx), 18C15.5, DBCN, Dbct, DC, DCX, LISX, SCLH, XLIS

Bezeichner auf Proteinebene für Doublecortin

  • doublecortex; lissencephaly, X-linked (doublecortin)
  • doublecortin
  • doublecortex
  • doublin
  • lis-X
  • lissencephalin-X
  • neuronal migration protein doublecortin
  • lissencephaly, X-linked (doublecortin)
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