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Hamster Monoclonal XRCC6 Primary Antibody für ICC, FACS - ABIN151413
Doster, Ziegler, Foermer, Rieker, Heeg, Bekeredjian-Ding: Phosphorothioate-modified CpG oligodeoxynucleotides mimic autoantigens and reveal a potential role for Toll-like receptor 9 in receptor revision. in Immunology 2013
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Human Monoclonal XRCC6 Primary Antibody für IF, IHC (p) - ABIN560973
Nishii, Nakano, Nakamura, Wate, Shinde, Kaneko, Kusaka: Myonuclear breakdown in sporadic inclusion body myositis is accompanied by DNA double strand breaks. in Neuromuscular disorders : NMD 2011
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Human Monoclonal XRCC6 Primary Antibody für IHC (fp), IF - ABIN966469
Ajmani, Satoh, Reap, Cohen, Reeves: Absence of autoantigen Ku in mature human neutrophils and human promyelocytic leukemia line (HL-60) cells and lymphocytes undergoing apoptosis. in The Journal of experimental medicine 1995
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Human Monoclonal XRCC6 Primary Antibody für IF, IHC (p) - ABIN2475248
Slupianek, Poplawski, Jozwiakowski, Cramer, Pytel, Stoczynska, Nowicki, Blasiak, Skorski: BCR/ABL stimulates WRN to promote survival and genomic instability. in Cancer research 2011
Human Polyclonal XRCC6 Primary Antibody für ELISA, WB - ABIN547944
Ribes-Zamora, Mihalek, Lichtarge, Bertuch: Distinct faces of the Ku heterodimer mediate DNA repair and telomeric functions. in Nature structural & molecular biology 2007
Human Monoclonal XRCC6 Primary Antibody für ELISA, FACS - ABIN4881267
Ishida, Akita, Mori, Tanida, Toda, Inoue, Nakada: Negative regulation of Toll-like receptor-4 signaling through the binding of glycosylphosphatidylinositol-anchored glycoprotein, CD14, with the sialic acid-binding lectin, CD33. in The Journal of biological chemistry 2014
Human Polyclonal XRCC6 Primary Antibody für IF, IP - ABIN6150312
Zhang, Chang, Sun, Chen, Yang, Tang, Jing, Kang, He, Wu, Wei, Wang, Xu, Zhu, Shen, Zeng, Wang, Liu, Zhang, Mao, Jiang, Sun: Histone H3K27 methylation modulates the dynamics of FANCD2 on chromatin to facilitate NHEJ and genome stability. in Journal of cell science 2018
Human Polyclonal XRCC6 Primary Antibody für IF, IHC - ABIN5663801
Li, Zhang, Chen, Guo, Zhang, Tang, Xu, Zhang, Tao, Wang, Jiang, Sun, Mao: Impaired DNA double-strand break repair contributes to the age-associated rise of genomic instability in humans. in Cell death and differentiation 2017
Study demonstrated that Ku70 forms a stable complex with HIV-1 integrase. Two binding sites in Ku70 were identified to be important for its binding to HIV1 integrase.
demonstrated that the interaction of Ets-1 with DNA-PK was mediated through the Ku70 subunit and was mapped to the C-terminal region of Ets-1 and the C-terminal part of Ku70 including SAP domain
KU70 defect influenced the expression of P53, BCL2 and BAX, remaining Jurkat cells in a pro-apoptosis status and KU70 silencing prolonged the survival time and impaired the tumorigenesis ability in Jurkat-xenografted mice.
Small cell lung cancer (SCLC) subtype had amplified risk with XRCC7 6721G>T. Gene-environment interaction analysis revealed that XRCC6 61C>G showed a strong protective effect towards lung cancer. Survival analysis revealed poor prognosis in case of XRCC6 61C>G SCLC subtype. XRCC7 6721G>T subjects with SCLC subtype showed an increased susceptibility while poor prognosis in case of XRCC6 61C>G.
verexpression of USP50 has no effect on Ku70 mRNA levels, while it reduces Ku70 protein levels by promoting Ku70 degradation, suggesting that USP50 may indirectly regulate Ku70 protein stability.
Observations suggest that IER5 is a novel regulator of the non-homologous end-joining pathway pathway for DNA double-strand breaks repair, possibly through its interaction with PARP1 and Ku70.
The DNA binding domain of Ku70 was essential for formation of the Ku70-STING complex. Knocking down STING in primary human macrophages inhibited their ability to produce IFN-lambda1 in response to transfection with DNA or infection with the DNA virus HSV-2 (herpes simplex virus-2). Together, these data suggest that STING mediates the Ku70-mediated IFN-lambda1 innate immune response to exogenous DNA or DNA virus infection.
analysis of a novel cellular stress response mechanism in cancer cells and a key role of LSD1/SIRT1/KU70 dynamic interaction in regulating DNA repair and mutation acquisition
Single nucleotide polymorphisms in the Ku70 gene XRCC6 were independently associated with Elevated Creatine Kinase Levels in Unhealthy Male Nonagenarians.
Although PAXX-deficient cells lack c-NHEJ phenotypes, PAXX forms a stable ternary complex with Ku bound to DNA. Thus, PAXX plays an accessory role during c-NHEJ that is largely overlapped by XLF's function.
HTLV-1 infection enhanced the association between Ku70 and stimulator of IFN genes, suggesting that stimulator of IFN genes was involved in Ku70-mediated host defenses against HTLV-1 infection; findings suggest a new sensor that detects HTLV-1 reverse transcription intermediate and controls HTLV-1 replication
Nuclear PTEN interferes with binding of Ku70 at double-strand breaks through post-translational poly(ADP-ribosyl)ation.
Results show that DDB2 is critical for chromatin association of XRCC5/6 in the absence of DNA damage and provide evidence that XRCC5/6 are functional partners of DDB2 in its transcriptional stimulatory activity.
High KU70 expression is associated with drug resistance in glioblastoma.
These results suggest that Ku-mediated repression of p53 mRNA translation constitutes a novel mechanism linking DNA repair and mRNA translation.
VCP removes sterically trapped Ku70/80 rings from DNA in double-strand break repair.
found that the rs228593, rs2267437 and rs1805388 functional polymorphisms probably alter the level of expression of the ATM, XRCC6 and LIG4 genes, respectively, being important in the maintenance of genomic instability in MDS
Data show that the increased acetylation of Ku autoantigen 70kDa (Ku70) in sirtuin 6 protein (SIRT6)-depleted cells disrupt its interaction with Bax apoptosis regulator protein (Bax), which finally resulted in Bax mitochondrial translocalization.
Ku70 (XRCC6) was found to bind directly within the CR4 of E1A from human adenovirus type 5.
periodic phosphorylation of Ku70 by cyclin-cyclin dependent kinases prevents the interaction of Ku with replication origin after initiation events in S-phase.
Data show that phosphorylated Ku70 S155 interacts with the Aurora B kinase and leads to inhibition of its activity.
Ku70 is epistatic with XLF and DNA-PKcs and support a model in which inactivation of Ku70 allows DNA lesions to become accessible to alternative DNA repair pathways (other than Classical Non-Homologous End-Joining (C-NHEJ)).
Study found that emphysema occurred in ku70(-/-) mice at the age of three-months old, and that Bax deficiency was able to suppress it. These results suggest that Bax-mediated apoptosis induces emphysema in ku70(-/-) mice.
Bax deficiency appeared to delay the development of emphysema. This study suggests that enhanced Bax activity exacerbates the negative impact of Ku70 deletion
Ku (ku70/ku80 heterodimer)roles in nonhomologous end joining and base excision repair pathways of DNA repair are overviewed.
A novel role for free Ku70 and free Ku80 in altering base excision repair.
A novel function of Ku70 essential for colon homeostasis.
Overexpression of Bcl2 rescues the hematopoietic stem cell defect in Ku70-deficient mice by restoration of quiescence.
important for DNA repair in somatic cells and in late spermatocytes of the testis
This study highlights Ku70 as an important player not only in maintaining genomic stability through NHEJ-dependent functions, but also in regulating pancreatic beta-cell proliferation, a novel NHEJ-independent function.
Ku70/80 binds to DNA double strand breaks (DSB) in all cell cycle stages and is likely actively displaced from DSB ends to free the DNA ends for DNA end resection and thus homologous recombination to occur.
The findings suggest that Artemis can work in not only the Ku-dependent repair process, but also the Ku-independent process at DNA double-strand break in living epithelial cells.
These findings clearly indicate that Ku70 plays a key role in regulation of the Ku80 expression level in and the radioresistance of lung epithelial cells.
Ku70/86 binds to the Apaf1 promoter and represses its activity.
a conserved critical Ku70 role for FOXO function toward coordination of a survival program
Ku70-deficient B cells have reduced, but still substantial, immunoglobulins class switch recombination
Ku can be identified as an effective 5'-dRP/AP lyase; data support an unexpected direct role for Ku in end-processing steps
Ku70 is a regulator of Bax-mediated pathogenesis in laminin-alpha2-deficiency muscle cells.
Data show that DSB promote PP2A to associate with Ku 70 and Ku 86.
Antioxidants and lower oxygen tension reduced the high levels of neuronal death in primary cortical cultures derived from Ku70(-/-) mice, but not the low levels of cell death in wildtype cortical cultures
The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus.
ATP-dependent DNA helicase 2 subunit 1
, ATP-dependent DNA helicase II, 70 kDa subunit
, X-ray repair complementing defective repair in Chinese hamster cells 6 (Ku autoantigen, 70kDa)
, X-ray repair cross-complementing protein 6
, 5'-dRP lyase Ku70
, 5'-deoxyribose-5-phosphate lyase Ku70
, 70 kDa subunit of Ku antigen
, ATP-dependent DNA helicase II 70 kDa subunit
, CTC box binding factor 75 kDa subunit
, CTC box-binding factor 75 kDa subunit
, DNA repair protein XRCC6
, Ku autoantigen p70 subunit
, Ku autoantigen, 70kDa
, lupus Ku autoantigen protein p70
, thyroid autoantigen 70kD (Ku antigen)
, thyroid autoantigen 70kDa (Ku antigen)
, thyroid-lupus autoantigen p70
, 5'-dRP/AP lyase Ku70
, Ku p70
, ku autoantigen protein p70 homolog
, thyroid autoantigen 70 kDa
, Ku70 DNA-binding component of DNA-dependent proteinkinase complex (thyroid autoantigen 70 kDa)
, thyroid autoantigen
, X-ray repair cross-complementing protein 5