anti-XRCC1 (XRCC1) Antikörper

Bezeichnung:: anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 1 Antikörper (XRCC1)

Auf www.antikoerper-online.de finden Sie aktuell 126 X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 1 (XRCC1) Antikörper von 23 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen XRCC1 Proteine (6) und XRCC1 Kits (2) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 140 XRCC1 Produkte verfügbar.

Synonyme:: MGC80909, RCC, Xrcc-1, XRCC1

Alle Antikörper anzeigen	Gen	GeneID	UniProt
	XRCC1	7515	P18887
	XRCC1	22594	Q60596
	XRCC1	84495	Q9ESZ0
Alle Spezies anzeigen Weitere Synonyme anzeigen

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Verknüpfte Pathways mit anti-XRCC1 Antikörper

DNA Reparatur

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Human X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 1 (XRCC1) Interaktionspartner

We confirmed that Arg399Gln polymorphism of XRCC1 gene is a potential predictor for susceptibility to NPC (zeige NPC1 Antikörper), especially for Asians
Review/Meta-analysis: XRCC1 Arg399Gln polymorphism might be associated with genetic susceptibility to systemic lupus erythematosus in Asians and Caucasians.
Infants born to women with specific AHR (zeige AHR Antikörper) and XRCC1 genotypes may have higher genetic risks for birth weight reduction
XRCC1 Arg399Gln and Arg194Trp variants may modify the susceptibility to gynecologic cancers based on ethnicity and type.
the XRCC1 Arg399Gln GA variant might be risk alleles for cervical cancer susceptibility in the Chinese population (meta-analysis).
studied SNPs in XRCC1 and XPD (zeige ERCC2 Antikörper) have no association with the incidence of age related cataract in the analyzed group of subjects.
our data confirmed the individual susceptibility to BC resulting from polymorphic markers of DNA repair genes (XRCC1), apoptosis genes (TP53 (zeige TP53 Antikörper)), as well as of apoptosis inhibition genes (MDM2 (zeige MDM2 Antikörper)).
Meta-analysis: in Non-Small-Cell Lung Carcinoma patients treated with platinum-based regimen, XRCC1 194Arg allele suggest poor objective response rate, the GlnGln genotype of XRCC1 399 suggest poorer overall survival in Caucasian patients, and longer PFS in Asian patients.
Our meta-analysis suggested that Arg399Gln in XRCC1 was associated with endometriosis risk. And especially in Asians, the A allele might be a preventive factor for this disease.
Our results showed that DNA base excision repair proteins APE-1 (zeige APEX1 Antikörper) and XRCC-1 are overexpressed in tongue squamous cell carcinoma and that XRCC-1 is associated with better clinical staging and nodal status.

Mouse (Murine) X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 1 (XRCC1) Interaktionspartner

Interaction with phosphorylated XRCC1 is a requirement for significant APTX (zeige APTX Antikörper) recruitment to cellular DNA damage and enzymatic activity in cell extracts.
this review focuses on the role of the oxidized form of XRCC1 in protection against extreme oxidative stress
Repair independent of the well documented XRCC1-PNKP (zeige PNKP Antikörper) interaction was studied. XRCC1 can mediate repair of strand breaks without PNKP (zeige PNKP Antikörper) binding.
data establish the importance of XRCC1 protein complexes for normal neurological function and identify PARP1 (zeige PARP1 Antikörper) as a therapeutic target in DNA strand break repair-defective disease
We have characterized the nuclear localization signal (NLS (zeige ALDH1A2 Antikörper)) of XRCC1 structurally using X-ray crystallography and functionally using fluorescence imaging.
Data indicate that maternal folate depletion during pregnancy and high-fat feeding from weaning altered gene expression of Ogg1 (zeige OGG1 Antikörper), Neil1 (zeige NEIL1 Antikörper), Mutyh (zeige MUTYH Antikörper) and Xrcc1 in the brain of adult offspring.
In cells with DNA base damage, PAR (zeige AFG3L2 Antikörper) serves to recruit XRCC1 that in turn binds and recruits pol beta (zeige POLB Antikörper), the primary DNA polymerase (zeige POLB Antikörper) of the base excision repair pathway.
Lig4 (zeige LIG4 Antikörper) and XRCC1 double-deficient cells switch as efficiently as Lig4 (zeige LIG4 Antikörper)-deficient cells, clearly indicating that XRCC1 is dispensable for A-EJ in CH12F3 cells during class switch recombination
findings firmly demonstrate that XRCC1 is not a requisite factor for A-EJ of chromosomal DSBs and raise the possibility that DNA ligase 1 (Lig1 (zeige LIG1 Antikörper)) may contribute more to A-EJ than previously considered
Data support a role for XRCC1 in microhomology-mediated joining, and imply that AID-induced single-strand breaks in Igh variable and switch regions become substrates simultaneously for BER and mutagenesis pathways.

XRCC1 Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.

Alternative names and synonyms associated with XRCC1

X-ray repair complementing defective repair in Chinese hamster cells 1 (xrcc1) Antikörper
X-ray repair cross complementing 1 (XRCC1) Antikörper
X-ray repair complementing defective repair in Chinese hamster cells 1 (Xrcc1) Antikörper
X-ray repair cross complementing 1 (Xrcc1) Antikörper

MGC80909 Antikörper
RCC Antikörper
Xrcc-1 Antikörper
XRCC1 Antikörper

Bezeichner auf Proteinebene für XRCC1

X-ray repair complementing defective repair in Chinese hamster cells 1 , X-ray repair cross complementing protein 1 , DNA repair protein XRCC1-like , DNA repair protein XRCC1 , X-ray repair cross-complementing protein 1 , X-ray-repair, complementing defective, repair in Chinese hamster , x-ray repair cross-complementing group 1 protein

GENE ID	SPEZIES
446884	Xenopus laevis
456094	Pan troglodytes
476447	Canis lupus familiaris
616905	Bos taurus
711457	Macaca mulatta
100380033	Xenopus (Silurana) tropicalis
100390129	Callithrix jacchus
100458994	Pongo abelii
100469866	Ailuropoda melanoleuca
100519604	Sus scrofa
100580597	Nomascus leucogenys
7515	Homo sapiens
22594	Mus musculus
84495	Rattus norvegicus
100689414	Cricetulus griseus

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