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anti-Human XRCC1 Antikörper:
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Human Polyclonal XRCC1 Primary Antibody für ICC, IF - ABIN151964
Iles, Rulten, El-Khamisy, Caldecott: APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks. in Molecular and cellular biology 2007
Show all 3 Pubmed References
Review/Meta-analysis: XRCC1 Arg399Gln polymorphism might be associated with genetic susceptibility to systemic lupus erythematosus in Asians and Caucasians.
Infants born to women with specific AHR (zeige AHR Antikörper) and XRCC1 genotypes may have higher genetic risks for birth weight reduction
XRCC1 Arg399Gln and Arg194Trp variants may modify the susceptibility to gynecologic cancers based on ethnicity and type.
the XRCC1 Arg399Gln GA variant might be risk alleles for cervical cancer susceptibility in the Chinese population (meta-analysis).
studied SNPs in XRCC1 and XPD (zeige ERCC2 Antikörper) have no association with the incidence of age related cataract in the analyzed group of subjects.
our data confirmed the individual susceptibility to BC resulting from polymorphic markers of DNA repair genes (XRCC1), apoptosis genes (TP53 (zeige TP53 Antikörper)), as well as of apoptosis inhibition genes (MDM2 (zeige MDM2 Antikörper)).
Meta-analysis: in Non-Small-Cell Lung Carcinoma patients treated with platinum-based regimen, XRCC1 194Arg allele suggest poor objective response rate, the GlnGln genotype of XRCC1 399 suggest poorer overall survival in Caucasian patients, and longer PFS in Asian patients.
Our meta-analysis suggested that Arg399Gln in XRCC1 was associated with endometriosis risk. And especially in Asians, the A allele might be a preventive factor for this disease.
Our results showed that DNA base excision repair proteins APE-1 (zeige APEX1 Antikörper) and XRCC-1 are overexpressed in tongue squamous cell carcinoma and that XRCC-1 is associated with better clinical staging and nodal status.
The effect of the XRCC1 gene homozygosity, particularly Arg/Arg, on the risk for stomach cancer was elevated by a high intake of vegetable oils and salt.
Interaction with phosphorylated XRCC1 is a requirement for significant APTX (zeige APTX Antikörper) recruitment to cellular DNA damage and enzymatic activity in cell extracts.
this review focuses on the role of the oxidized form of XRCC1 in protection against extreme oxidative stress
Repair independent of the well documented XRCC1-PNKP (zeige PNKP Antikörper) interaction was studied. XRCC1 can mediate repair of strand breaks without PNKP (zeige PNKP Antikörper) binding.
data establish the importance of XRCC1 protein complexes for normal neurological function and identify PARP1 (zeige PARP1 Antikörper) as a therapeutic target in DNA strand break repair-defective disease
We have characterized the nuclear localization signal (NLS (zeige ALDH1A2 Antikörper)) of XRCC1 structurally using X-ray crystallography and functionally using fluorescence imaging.
Data indicate that maternal folate depletion during pregnancy and high-fat feeding from weaning altered gene expression of Ogg1 (zeige OGG1 Antikörper), Neil1 (zeige NEIL1 Antikörper), Mutyh (zeige MUTYH Antikörper) and Xrcc1 in the brain of adult offspring.
In cells with DNA base damage, PAR (zeige AFG3L2 Antikörper) serves to recruit XRCC1 that in turn binds and recruits pol beta (zeige POLB Antikörper), the primary DNA polymerase (zeige POLB Antikörper) of the base excision repair pathway.
Lig4 (zeige LIG4 Antikörper) and XRCC1 double-deficient cells switch as efficiently as Lig4 (zeige LIG4 Antikörper)-deficient cells, clearly indicating that XRCC1 is dispensable for A-EJ in CH12F3 cells during class switch recombination
findings firmly demonstrate that XRCC1 is not a requisite factor for A-EJ of chromosomal DSBs and raise the possibility that DNA ligase 1 (Lig1 (zeige LIG1 Antikörper)) may contribute more to A-EJ than previously considered
Data support a role for XRCC1 in microhomology-mediated joining, and imply that AID-induced single-strand breaks in Igh variable and switch regions become substrates simultaneously for BER and mutagenesis pathways.
The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
X-ray repair complementing defective repair in Chinese hamster cells 1
, X-ray repair cross complementing protein 1
, DNA repair protein XRCC1-like
, DNA repair protein XRCC1
, X-ray repair cross-complementing protein 1
, X-ray-repair, complementing defective, repair in Chinese hamster
, x-ray repair cross-complementing group 1 protein