anti-XRCC1 (XRCC1) Antikörper

Human X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 1 (XRCC1) Interaktionspartner

1. downregulation of XRCC1, which interacts with PARP1 and coordinates base excision repair, is an early event in human breast cancer pathogenesis

2. results reveal that XRCC1-contaning foci constitute newly recognized PML-like nuclear bodies that accrete and locally deliver essential factors for repair of single-strand DNA breaks in replication regions

3. XRCC1 Arg280His and Arg194Trp were associated with thyroid cancer in Pakistani population.

4. We conclude that the T-allele of XRCC1 c.1254C>T (rs2293035) and the C allele of c.1517G>C (rs139599857) genetic variants may be associated with increased hepatocellular carcinoma (HCC) risk among chronic hepatitis C patients.

5. The main aim of the current study was to evaluate the frequency distribution of single nucleotide polymorphism (SNP) Arg280His Exon 9 (C>G) (rs25489) of XRCC1 gene in Saudi Arabian population and its comparison with the worldwide ethnic groups.

6. Results suggest that the XRCC1-Arg399Gln polymorphism might be a risk factor for prostate cancer (PCa) and it could be considered as a prognostic and predictive biomarker for susceptible men.

7. Data suggest a model in which Cockayne syndrome protein B (CSB) plays a role in facilitating base excision repair (BER) progression at transcribed genes, probably to allow X-ray repair cross-complementing protein 1 (XRCC1) recruitment to BER-intermediates.

8. This is the first meta-analysis to investigate the association of XRCC1 polymorphisms (codon 399) and male infertility risk. Our results indicated that the XRCC1 Arg399Gln polymorphism was not associated with male infertility risk in the total studied populations [meta-analysis]

9. XRCC1 and XPD polymorphisms, cooking oil mist, and soot exposure history may be interactively correlated with non-small-cell lung cancer incidence for nonsmoking female patients.

10. XRCC1 polymorphism is associated with DNA damage in tobacco farmers.

11. Low XRCC1 expression is associated with increased DNA damage and male infertility.

12. This study found that an XRCC1 fragment, comprising residues 166-436, binds tightly to PNKP and DNA and efficiently activates PNKP's kinase activity.

13. Polymorphic variant XRCC1 HNSCC patients treated with CCRT have significantly increased acute radiation morbidities

14. carrying the allele T of XRCC1 rs1799782 polymorphism and the allele G of APEX rs1130409 polymorphism increased the risk of developing Paget's disease of bone.

15. a significant association between XRCC1 Arg399Gln and hepatocellular carcinoma risk was found in healthy controls in the general population but not in hospital controls.

16. XRCC1 gene is highly associated with susceptibility to cervical cancer risk in a female population in southwestern China.

17. Via interference with XRCC1/PARP1-mediated base excision repair.

18. we showed that CHK2-dependent phosphorylation of PARP1 not only regulates its cellular localization but also promotes its catalytic activity and its interaction with XRCC1. These findings indicate that CHK2 exerts a multifaceted impact on PARP1 in response to oxidative stress to facilitate DNA repair and to maintain cell survival.

19. Study shows that polymorphisms in the genes coding for the DNA damage repair enzymes - OGG1 Ser326Cys (rs1052133) and XRCC1 Arg399Gln (rs25487) - may be associated with poor sperm parameters and male infertility.

20. Data suggest that phosphorylation of T358 and T367 and p38 signaling are important for proper regulation of XRCC1 recruitment to DNA damage.

Mouse (Murine) X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 1 (XRCC1) Interaktionspartner

1. Unrepaired single strand DNA breaks (SSBs) activate DNA damage response and increase the expression of inflammatory cytokines through NF-kappaB signalling. Pressure overload-induced heart failure is more severe in the mice lacking XRCC1, an essential protein for SSB repair.

2. Interaction with phosphorylated XRCC1 is a requirement for significant APTX recruitment to cellular DNA damage and enzymatic activity in cell extracts.

3. this review focuses on the role of the oxidized form of XRCC1 in protection against extreme oxidative stress

4. Repair independent of the well documented XRCC1-PNKP interaction was studied. XRCC1 can mediate repair of strand breaks without PNKP binding.

5. data establish the importance of XRCC1 protein complexes for normal neurological function and identify PARP1 as a therapeutic target in DNA strand break repair-defective disease

6. We have characterized the nuclear localization signal (NLS) of XRCC1 structurally using X-ray crystallography and functionally using fluorescence imaging.

7. Its allelic loss results in increased brain damage and reduced recovery from ischemic stroke.

8. Data indicate that maternal folate depletion during pregnancy and high-fat feeding from weaning altered gene expression of Ogg1, Neil1, Mutyh and Xrcc1 in the brain of adult offspring.

9. In cells with DNA base damage, PAR serves to recruit XRCC1 that in turn binds and recruits pol beta, the primary DNA polymerase of the base excision repair pathway.

10. Lig4 and XRCC1 double-deficient cells switch as efficiently as Lig4-deficient cells, clearly indicating that XRCC1 is dispensable for A-EJ in CH12F3 cells during class switch recombination

11. findings firmly demonstrate that XRCC1 is not a requisite factor for A-EJ of chromosomal DSBs and raise the possibility that DNA ligase 1 (Lig1) may contribute more to A-EJ than previously considered

12. Data support a role for XRCC1 in microhomology-mediated joining, and imply that AID-induced single-strand breaks in Igh variable and switch regions become substrates simultaneously for BER and mutagenesis pathways.

13. Results indicates that XRCC1 haploinsufficiency has little effect on chronological longevity and many key biological markers of aging, but may adversely affect normal animal development or increase disease susceptibility to a relevant genotoxic exposure.

14. data reveal that the critical biological role of Lig3 is to maintain mtDNA integrity and not Xrcc1-dependent DNA repair

15. results establish a role for Lig3 in mitochondria, but distinguish it from its interacting protein Xrcc1

16. poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III utilize an alternative route for DNA double-strand breaks rejoining

17. These results identify a novel role for FoxM1 in the transcriptional response during DNA damage/checkpoint signaling and show a novel mechanism by which Chk2 protein regulates expression of DNA repair enzymes.

18. the XRCC1 Arg399Gln and RAD51 5'UTR G135C polymorphisms have roles in breast cancer aggressiveness

19. E2F1 regulates the base excision repair gene XRCC1 and promotes DNA repair