anti-XRCC1 (XRCC1) Antikörper

Human X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 1 (XRCC1) Interaktionspartner

1. Polymorphic variants of XRCC1 Arg399Gln and XPD Lys751Gln are not associated with the risk of gastric cancer in the Kashmiri population.

2. The effects of chronic smoking on oral mucosa led to the methylation of genes MRE11A PMS2, XRCC1 and MLH3, but resulted in a reduction of gene expression of MRE11A and PMS2, which showed >/=50% methylation. These results provide evidence that smoking cause methylation and reduced expression of repair genes.

3. T-77C and Arg399Gln polymorphisms of the XRCC1 gene, as well as the 186C>T and Val158Met polymorphisms of the COMT gene, increased the risk of lung cancer in non-smoking women.

4. XRCC1 Arg194Trp, Arg280His, and Arg399Gln did not affect overall survival after platinum-based chemotherapy in ovarian cancer patients. However, disease status could affect the relationship between Arg399Gln and overall survival in these patients

5. results suggested an increased risk for Non-Hodgkin Lymphoma regarding the XRCC1 Arg194Trp polymorphism in a Romania population, while XRCC1 Arg399Gln polymorphism is not associated with Non-Hodgkin Lymphoma.

6. Our present case-control study has shown that tryptophan allele (R/W-W/W genotype) in XRCC1A (Arg194Trp) gene significantly increased the risk of breast cancer 1.44-fold..the present case-control study did not reveal any significant association of XRCC3 (Thr241Met) polymorphism with the risk of breast cancer in females from NE region of India

7. The C allele of rs861539 and T allele of rs1799782 Interaction between rs1799782 and obesity and haplotype T- C were all associated with increased papillary thyroid cancer risk.

8. We confirmed that Arg399Gln polymorphism of XRCC1 gene is a potential predictor for susceptibility to NPC, especially for Asians

9. Review/Meta-analysis: XRCC1 Arg399Gln polymorphism might be associated with genetic susceptibility to systemic lupus erythematosus in Asians and Caucasians.

10. Infants born to women with specific AHR and XRCC1 genotypes may have higher genetic risks for birth weight reduction

11. XRCC1 Arg399Gln and Arg194Trp variants may modify the susceptibility to gynecologic cancers based on ethnicity and type.

12. the XRCC1 Arg399Gln GA variant might be risk alleles for cervical cancer susceptibility in the Chinese population (meta-analysis).

13. studied SNPs in XRCC1 and XPD have no association with the incidence of age related cataract in the analyzed group of subjects.

14. our data confirmed the individual susceptibility to BC resulting from polymorphic markers of DNA repair genes (XRCC1), apoptosis genes (TP53), as well as of apoptosis inhibition genes (MDM2).

15. Meta-analysis: in Non-Small-Cell Lung Carcinoma patients treated with platinum-based regimen, XRCC1 194Arg allele suggest poor objective response rate, the GlnGln genotype of XRCC1 399 suggest poorer overall survival in Caucasian patients, and longer PFS in Asian patients.

16. Our meta-analysis suggested that Arg399Gln in XRCC1 was associated with endometriosis risk. And especially in Asians, the A allele might be a preventive factor for this disease.

17. Our results showed that DNA base excision repair proteins APE-1 and XRCC-1 are overexpressed in tongue squamous cell carcinoma and that XRCC-1 is associated with better clinical staging and nodal status.

18. The effect of the XRCC1 gene homozygosity, particularly Arg/Arg, on the risk for stomach cancer was elevated by a high intake of vegetable oils and salt.

19. DNA sequencing was performed for six single-nucleotide polymorphisms in the GSTP1, RAD51, XRCC1 and XRCC3 genes in BC patients and the control group. Two variants in the 5'-UTR of the XRCC3 and RAD51 genes showed a significant association with susceptibility to breast cancer. Additionally, authors reported 2 mutations in intron 7 of the XRCC3 gene.

20. The SNPs in CYP1A1, GSTP1 and XRCC1 genes did not show significant association with complete remission (CR) rate, overall survival (OS) or event free survival (EFS). However, XRCC1 Arg194Trp SNP was associated with higher drug toxicity; carriers of variant genotypes (CT and TT) had a significantly higher frequency of myelosuppression compared to those with the wild CC genotype

Mouse (Murine) X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 1 (XRCC1) Interaktionspartner

1. Unrepaired single strand DNA breaks (SSBs) activate DNA damage response and increase the expression of inflammatory cytokines through NF-kappaB signalling. Pressure overload-induced heart failure is more severe in the mice lacking XRCC1, an essential protein for SSB repair.

2. Interaction with phosphorylated XRCC1 is a requirement for significant APTX recruitment to cellular DNA damage and enzymatic activity in cell extracts.

3. this review focuses on the role of the oxidized form of XRCC1 in protection against extreme oxidative stress

4. Repair independent of the well documented XRCC1-PNKP interaction was studied. XRCC1 can mediate repair of strand breaks without PNKP binding.

5. data establish the importance of XRCC1 protein complexes for normal neurological function and identify PARP1 as a therapeutic target in DNA strand break repair-defective disease

6. We have characterized the nuclear localization signal (NLS) of XRCC1 structurally using X-ray crystallography and functionally using fluorescence imaging.

7. Its allelic loss results in increased brain damage and reduced recovery from ischemic stroke.

8. Data indicate that maternal folate depletion during pregnancy and high-fat feeding from weaning altered gene expression of Ogg1, Neil1, Mutyh and Xrcc1 in the brain of adult offspring.

9. In cells with DNA base damage, PAR serves to recruit XRCC1 that in turn binds and recruits pol beta, the primary DNA polymerase of the base excision repair pathway.

10. Lig4 and XRCC1 double-deficient cells switch as efficiently as Lig4-deficient cells, clearly indicating that XRCC1 is dispensable for A-EJ in CH12F3 cells during class switch recombination

11. findings firmly demonstrate that XRCC1 is not a requisite factor for A-EJ of chromosomal DSBs and raise the possibility that DNA ligase 1 (Lig1) may contribute more to A-EJ than previously considered

12. Data support a role for XRCC1 in microhomology-mediated joining, and imply that AID-induced single-strand breaks in Igh variable and switch regions become substrates simultaneously for BER and mutagenesis pathways.

13. Results indicates that XRCC1 haploinsufficiency has little effect on chronological longevity and many key biological markers of aging, but may adversely affect normal animal development or increase disease susceptibility to a relevant genotoxic exposure.

14. data reveal that the critical biological role of Lig3 is to maintain mtDNA integrity and not Xrcc1-dependent DNA repair

15. results establish a role for Lig3 in mitochondria, but distinguish it from its interacting protein Xrcc1

16. poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III utilize an alternative route for DNA double-strand breaks rejoining

17. These results identify a novel role for FoxM1 in the transcriptional response during DNA damage/checkpoint signaling and show a novel mechanism by which Chk2 protein regulates expression of DNA repair enzymes.

18. the XRCC1 Arg399Gln and RAD51 5'UTR G135C polymorphisms have roles in breast cancer aggressiveness

19. E2F1 regulates the base excision repair gene XRCC1 and promotes DNA repair