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Human RAD51 Protein expressed in Escherichia coli (E. coli) - ABIN2452204
Kurumizaka, Aihara, Kagawa, Shibata, Yokoyama: Human Rad51 amino acid residues required for Rad52 binding. in Journal of molecular biology 1999
Show all 2 Pubmed References
Human RAD51 Protein expressed in Wheat germ - ABIN1317281
De, Donahue, Tabah, Castro, Mraz, Cruise, Campbell: A novel interaction [corrected] of nucleolin with Rad51. in Biochemical and biophysical research communications 2006
he results of the study indicate that Akt1 (zeige AKT1 Proteine) seems to be a regulatory component in the homologous recombination (HR) repair of DNA double-strand break in a Rad51-dependent manner.
RAD51 135G/C polymorphism was a risk factor for the three common gynecological tumors, especially for endometrial cancer among hospital-based populations.
Fanconi anemia (zeige PALB2 Proteine)-associated RAD51 mutants are defective at stalled fork protection. Mutant RAD51 nucleoprotein filaments are unstable due to aberrant ATP binding and hydrolysis.
PTEN promotes DNA repair through Rad51-dependnent homologous recombination.
Inactivation of homologous recombination factors BRCA1, BRCA2 (zeige BRCA2 Proteine), or RAD51 hypersensitizes cells to acetaldehyde treatment, in spite of the Fanconi anemia (zeige PALB2 Proteine) pathway being functional.
Cells with mutated PTEN showed over-activation of the PI3K (zeige PIK3CA Proteine)/mTOR (zeige FRAP1 Proteine) pathway. These cells were more sensitive to PARP inhibition compared to PTEN wild-type cells. In addition, PI3K (zeige PIK3CA Proteine) inhibitor treatment reduced RAD51 foci formation in PTEN mutated cells, and sensitized these cells to PARP inhibitor.
DNA sequencing was performed for six single-nucleotide polymorphisms in the GSTP1 (zeige GSTP1 Proteine), RAD51, XRCC1 (zeige XRCC1 Proteine) and XRCC3 (zeige XRCC3 Proteine) genes in BC patients and the control group. Two variants in the 5'-UTR of the XRCC3 (zeige XRCC3 Proteine) and RAD51 genes showed a significant association with susceptibility to breast cancer. Additionally, authors reported 2 mutations in intron 7 of the XRCC3 (zeige XRCC3 Proteine) gene.
our data demonstrated for the first time that inhibition of RAD51 suppressed the cervical cancer cell proliferation and the growth of cervical cancer xenografts by attenuating cell cycle transition, which could be a functional link between RAD51 and cyclin D1 (zeige CCND1 Proteine) and p21 (zeige CDKN1A Proteine).
Low RAD51 gene expression is associated with breast cancer.
(-)-Guaiol is involved in cell autophagy to regulate the expression of RAD51, leading to double-strand breaks triggered cell apoptosis
Meiosis progression and female age affect expression profile of DNA repair RAD51 gene in bovine oocytes.
RAD51 plays a crucial role in halting cell death program induced by ionizing radiation in bovine oocytes.
Describe and demonstrate a model showing loss of RAD51 leads to Fanconi anemia (zeige PALB2 Proteine)-like symptoms in zebrafish.
Although the presence of RAD51 protein provides essential support for the action of DMC1 (zeige DMC1 Proteine), these results show no significant effect of the absence of RAD51 strand-exchange activity on meiotic crossing-over rates or patterns in different chromosomal regions or across the whole genome of Arabidopsis, strongly supporting the argument that DMC1 (zeige DMC1 Proteine) catalyses repair of all meiotic DNA breaks, not only non-sister cross-overs.
The authors find that RBR1 is also required for RAD51 localization to DNA lesions.
RAD51 forms a protein complex with AtRAD51C (zeige RAD51C Proteine)-AtXRCC3 to facilitate RAD51 localization on chromosomes for meiotic recombination.
Our data demonstrate that RAD51 plays a supporting role for DMC1 (zeige DMC1 Proteine) in meiotic recombination in the flowering plant, Arabidopsis.
The present study demonstrates for the first time the involvement of a host RAD51 protein in mungbean yellow mosaic India virus replication.
Results demonstrate that DMC1 functions independently and spatially separated from RAD51 during meiosis and that ATR is an integral part of the regular meiotic program.
Establishment and stabilisation of pairing of homologous centromeric and pericentromeric regions depends principally upon DMC1 (zeige DMC1 Proteine), while pairing and synapsis of euchromatic chromosome arms of homologues requires the presence of RAD51
AtRAD51 is required to ensure the fidelity of homologous recombination during interchromosomal exchanges. It may also be required to ensure the fidelity of homologous recombination in the interchromosomal exchanges initiated by AtDMC1.
AtBRCA2 is required for proper meiotic synapsis and mediates the recruitment of AtRAD51 and AtDMC1.
Study provides the molecular evidence showing that the BRCA2 (zeige BRCA2 Proteine)-RAD51 complex, known for its function in HR, also plays a direct and specific role in transcription regulation during plant immune responses.
RAD51 plays a critical role in maintaining chromosome integrity and mitochondrial activity during porcine oocyte maturation.
The complete cDNA sequences of the pig RAD51, RAD52 (zeige RAD52 Proteine), and RAD54 (zeige RAD54L Proteine) genes, which are closely related to homologous recombination events, arae identified using molecular cloning technique in pigs.
Data show that the expression of miR (zeige MLXIP Proteine)-193b-3p and Rad51 was altered in in response to low-dose irradiation (LDIR) exposure.
The anti-recombinase (zeige RAG1 Proteine) activity of BLM (zeige BLM Proteine) is of general importance for normal retention of RAD51 at DNA double strand break sites and regulation of homologous recombination.
Our results thus help establish the functional relevance of the trimeric RAD51-SWI5 (zeige SWI5 Proteine)-SFR1 (zeige SFR1 Proteine) complex and provide insights into the mechanistic underpinnings of homology-directed DNA repair in mammalian cells.
Unlike directly induced DSBs, secondary DSBs were not efficiently repaired, although Rad51 and 53BP1 (zeige TP53BP1 Proteine) were recruited to these sites. H2AX (zeige H2AFX Proteine) was dramatically stabilized in response to DSBs directly caused by gamma-rays, enabling gammaH2AX (zeige H2AFX Proteine) foci formation and DSB repair, whereas H2AX (zeige H2AFX Proteine) was barely stabilized in response to secondary DSBs, in which gammaH2AX (zeige H2AFX Proteine) foci were small and DSBs were not efficiently repaired
HOP2 (zeige PSMC3IP Proteine)-MND1 (zeige MND1 Proteine) enhances the interaction of RAD51 with nucleotide cofactors and modifies its DNA-binding specificity.
Rad51 repaired DNA damage.
BRCA2 (zeige BRCA2 Proteine)-mediated sequestration of nuclear RAD51 serves to prevent inappropriate DNA interactions.
increased Rad51 concentration and homology length interact synergistically to promote 3' extension, presumably as a result of enhanced Brca2 (zeige BRCA2 Proteine)-mediated Rad51 polymerization
Results suggest that cellular levels of Brca2 (zeige BRCA2 Proteine) and Rad51 are mutually dependent on each other, and that low levels of these proteins provide selective pressure for reduction of p53 (zeige TP53 Proteine), which permits cell growth
FBH1 restraining RAD51 DNA binding under unperturbed growth conditions to prevent unwanted or unscheduled DNA recombination.
Brca2 (zeige BRCA2 Proteine) and Rad51 prevent formation of abnormal DNA replication intermediates, whose processing by Smarcal1 (zeige SMARCAL1 Proteine) and Mre11 (zeige MRE11A Proteine) predisposes to genome instability.
Data show that MRE11- and RAD51-dependent fork repair leading to reloading of the GINS onto the MCM-CDC45 complex still engaged with the DNA could be sufficient to restore a functional CDC45-MCM-GINS (CMG) helicase complex.
By promoting CtIP (zeige RBBP8 Proteine)-dependent resection of double-strand break (DSB) ends while preventing Rad51 chromatin assembly, Cdk1 (zeige CDK1 Proteine) inhibits both the nonhomologous and homologous modes of DSB repair during mitosis.
Rad51 has a role at the replication fork protecting DNA from Mre11 (zeige MRE11A Proteine)-dependent degradation.
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene.
BRCA1/BRCA2-containing complex, subunit 5
, DNA repair protein RAD51 homolog 1
, RAD51 homolog A
, RecA, E. coli, homolog of
, RecA-like protein
, recombination protein A
, RAD51 homolog (RecA homolog, E. coli)
, homolog to S.cerevisiae
, RAD51 homolog
, DNA repair protein RAD51
, DNA repair protein RAD51 homolog A
, RAD51 homolog (RecA homolog)
, DNA repair protein RAD51-like 1