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Human Monoclonal MCM7 Primary Antibody für IF, IHC (p) - ABIN561764
Köhler, Kreuter, Rozynkowski, Rahmel, Uhl, Tannapfel, Schmidt, Meier: Validation of different replication markers for the detection of beta-cell proliferation in human pancreatic tissue. in Regulatory peptides 2010
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Human Polyclonal MCM7 Primary Antibody für ChIP, ICC - ABIN441356
Hubbi, Luo, Baek, Semenza: MCM proteins are negative regulators of hypoxia-inducible factor 1. in Molecular cell 2011
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Human Polyclonal MCM7 Primary Antibody für PLA, WB - ABIN151719
Nash, Chen, Muzyczka: Complete in vitro reconstitution of adeno-associated virus DNA replication requires the minichromosome maintenance complex proteins. in Journal of virology 2008
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Human Polyclonal MCM7 Primary Antibody für IP, WB - ABIN440771
Panneerselvam, Pickering, Han, Li, Zheng, Zhang, Zhang, Fei: Basal level of FANCD2 monoubiquitination is required for the maintenance of a sufficient number of licensed-replication origins to fire at a normal rate. in Oncotarget 2014
Human Monoclonal MCM7 Primary Antibody für FACS, IF - ABIN5583309
Koonin: A common set of conserved motifs in a vast variety of putative nucleic acid-dependent ATPases including MCM proteins involved in the initiation of eukaryotic DNA replication. in Nucleic acids research 1993
Human Polyclonal MCM7 Primary Antibody für IF, IP - ABIN2452047
Fujita, Kiyono, Hayashi, Ishibashi: hCDC47, a human member of the MCM family. Dissociation of the nucleus-bound form during S phase. in The Journal of biological chemistry 1996
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Results proved that MCM7 proliferative index is a better method for identifying patients with risk of recurrence in patients surgically resected for meningiomas compared with the traditional methods used in the current clinical practice.
MCM7-cyclin D1 (zeige CCND1 Antikörper) pathway may participate in cancer progression.
The MCM7 directly binds to the centrosomal linker protein (zeige LAT Antikörper) Cep68 in vitro and complexes with Cep68 and VHL (zeige VHL Antikörper) in vivo.
The results clearly demonstrate 7q21-22 amplification, MCM7, and its intronic miR (zeige MLXIP Antikörper)-25 are the major molecular switches involved in the complex oncogenic circuits of gastric cancer.
High MCM7 expression is associated with non-small cell lung cancer.
MCM4 (zeige MCM4 Antikörper) and MCM7 expression is significantly correlated with Ki-67 (zeige MKI67 Antikörper), Bmi1 (zeige BMI1 Antikörper), and cyclin E (zeige CCNE1 Antikörper) expression in esophageal adenocarcinoma, squamous cell carcinoma and precancerous lesions.
Data suggest that interaction of Mcm10 (zeige MCM10 Antikörper) with Mcm2-7 (zeige MCM2 Antikörper) multimer requires Mcm10 (zeige MCM10 Antikörper) domain that contains amino acids 530-655, which overlaps with domain required for stable retention of Mcm10 (zeige MCM10 Antikörper) on chromatin; Mcm10 (zeige MCM10 Antikörper) conserved domain (amino acids 200-482) is essential for DNA replication; both conserved domain and Mcm2-7 (zeige MCM2 Antikörper)-binding domain are required for full activity of Mcm10 (zeige MCM10 Antikörper).
Results show that the expression of MCM7 gene and its microRNA, miR (zeige MLXIP Antikörper)-106b-25 cluster is reduced under hypoxia.
This MCM4 (zeige MCM4 Antikörper) mutation affected human MCM4 (zeige MCM4 Antikörper)/6/7 complex formation, since the complex containing the mutant MCM4 (zeige MCM4 Antikörper) protein is unstable and the mutant MCM4 (zeige MCM4 Antikörper) protein is tend to be degraded.
Authors found that MCM7 highly expressed in K562 cells rather than that in normal neutrophils. Thus, lentivirus-mediated shRNA targeting MCM7 was used to suppress its endogenous expression in K562 cells and develop a novel therapeutic strategy for leukemia.
Unique pattern of ORC2 and MCM7 localization during DNA replication licensing in the mouse zygote.
cyclin D1 (zeige CCND1 Antikörper)/CDK4 (zeige CDK4 Antikörper) complexes play a direct role in altering an inhibitory RB.MCM7 complex possibly allowing for setting of the origin in preparation for DNA replication
MCM7 may be a highly informative biomarker for cervical cancer.
Substrate preference and helicase (zeige DNA2 Antikörper) actions of mouse MCM4 (zeige MCM4 Antikörper)/6/7 helicase (zeige DNA2 Antikörper) complexes.
Accumulation and dynamics of Mcm7 are described during oogenesis and the first embryonic cell cycle.
cellular DNA replication factor (zeige CDT1 Antikörper) MCM7 is involved in prostate cancer (CaP) and MCM7 gene expression was reduced by green tea catechins
DNA binding and helicase (zeige DNA2 Antikörper) activities of Mcm4 (zeige MCM4 Antikörper)/6/7 are significantly stimulated by Cdt1 (zeige CDT1 Antikörper)
Mcm2-7 (zeige MCM2 Antikörper) associate with Cdc45 (zeige CDC45 Antikörper) and GINS to form a relatively stable CMG (zeige CASK Antikörper) (Cdc45 (zeige CDC45 Antikörper)-MCM-GINS) complex.
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
, DNA replication licensing factor MCM7
, homolog of S. cerevisiae Cdc47
, minichromosome maintenance deficient 7
, hypothetical protein
, minichromosome maintenance protein 7
, minichromosome maintenance complex component 7
, minichromosome maintenance protein 2
, MCM7 minichromosome maintenance deficient 7
, minichromosome maintenance complex component 2
, DNA replication licensing factor MCM7-like
, mini chromosome maintenance deficient 7
, CDC47 homolog B
, DNA replication licensing factor mcm7-B
, minichromosome maintenance protein 7-B
, minichromosome maintenance 7
, minichromosome maintenance-PCR1
, CDC47 homolog A
, DNA replication licensing factor mcm7-A
, minichromosome maintenance protein 7-A
, Minichromosome maintenance protein 7