May modulate splice site selection during alternative splicing of pre-mRNAs. Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription (By similarity).
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Olsen, Blagoev, Gnad, Macek, Kumar, Mortensen, Mann: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, (2006) (PubMed).
Maita, Kitaura, Ariga, Iguchi-Ariga: "CIR, a corepressor of CBF1, binds to PAP-1 and effects alternative splicing." in: Experimental cell research, Vol. 303, Issue 2, pp. 375-87, (2005) (PubMed).
Zhou, Hayward: "Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex." in: Molecular and cellular biology, Vol. 21, Issue 18, pp. 6222-32, (2001) (PubMed).
Synonyme und alternative Namen zu CIR1
corepressor interacting with RBPJ, 1 (CIR1), corepressor interacting with RBPJ, 1 (Cir1), 1700023B02Rik, 1700023b02rik, 2810021A19Rik, Cicr, CIR, Cir, RGD1309199