CIITA Produkte
(Class II, Major Histocompatibility Complex, Transactivator (CIITA))
Kategorien
This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the 'master control factor' for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. [provided by RefSeq, Jul 2008].
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Ausgewählte CIITA Kategorien
CIITA Antikörper
High quality antibodies with extensive validation data.
CIITA Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene CIITA Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB, IHC (p)
Validierungen
- (1)
- (4)
Kat. Nr.
ABIN4886541
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Pig
Applikation
WB
Validierungen
- (3)
- (1)
Kat. Nr.
ABIN97339
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB, ELISA, IHC, IF, ICC
Validierungen
- (2)
Kat. Nr.
ABIN6257104
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene CIITA Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1349483
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
Tobacco (Nicotiana tabacum)
Validierungen
- (1)
Kat. Nr.
ABIN3134669
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Tobacco (Nicotiana tabacum)
Validierungen
- (1)
Kat. Nr.
ABIN3090387
Menge
1 mg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren CIITA Produkten
: "A super enhancer controls expression and chromatin architecture within the MHC class II locus." in: The Journal of experimental medicine, Vol. 217, Issue 2, (2020) (PubMed).: "Class II transactivator knockdown limits major histocompatibility complex II expression, diminishes immune rejection, and improves survival of allogeneic bone marrow stem cells in the infarcted heart." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 30, Issue 9, pp. 3069-82, (2016) (PubMed).
: "Autoregulatory loop between TGF-β1/miR-411-5p/SPRY4 and MAPK pathway in rhabdomyosarcoma modulates proliferation and differentiation." in: Cell death & disease, Vol. 6, pp. e1859, (2016) (PubMed).
: "Genome-wide CIITA-binding profile identifies sequence preferences that dictate function versus recruitment." in: Nucleic acids research, Vol. 43, Issue 6, pp. 3128-42, (2015) (PubMed).
: "Pollen-induced antigen presentation by mesenchymal stem cells and T cells from allergic rhinitis." in: Clinical & translational immunology, Vol. 2, Issue 10, pp. e7, (2014) (PubMed).
: "The 19S proteasome positively regulates histone methylation at cytokine inducible genes." in: Biochimica et biophysica acta, Vol. 1789, Issue 11-12, pp. 691-701, (2009) (PubMed).
Synonyme und alternative Namen zu CIITA
class II, major histocompatibility complex, transactivator (CIITA), class II major histocompatibility complex transactivator (CIITA), MHC class II transactivator (LOC710761), class II, major histocompatibility complex, transactivator (ciita), MHC class II transactivator (LOC100443575), class II transactivator (Ciita), MHC class II transactivator (LOC100736732), class II, major histocompatibility complex, transactivator (Ciita), C2ta, C2TA, CIITA, CIITAIV, EG669998, Gm9475, MHC2TA, Mhc2ta, NLRABezeichner auf Proteinebene für CIITA
- class II, major histocompatibility complex, transactivator
- class II transactivator-like
- class II transactivator
- MHC class II transactivator-like
- MHC class II transactivator
- MHC class II transactivator type III
- NLR family, acid domain containing
- nucleotide-binding oligomerization domain, leucine rich repeat and acid domain containing
- MHC class II transactivator type IV
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