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anti-Human SMAD6 Antikörper:
anti-Mouse (Murine) SMAD6 Antikörper:
anti-Rat (Rattus) SMAD6 Antikörper:
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Human Polyclonal SMAD6 Primary Antibody für ICC, IF - ABIN252409
Hogg, Etherington, Young, McNeilly, Duncan: Inhibitor of differentiation (Id) genes are expressed in the steroidogenic cells of the ovine ovary and are differentially regulated by members of the transforming growth factor-beta family. in Endocrinology 2010
Show all 6 Pubmed References
Human Monoclonal SMAD6 Primary Antibody für ELISA, WB - ABIN969405
Shen, Chen, Wang, Kaneki, Xing, Okeefe, Chen: Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation. in The Journal of biological chemistry 2006
Show all 3 Pubmed References
Mouse (Murine) Polyclonal SMAD6 Primary Antibody für WB - ABIN1881817
Ryan, Ryan, Fabre, Lawless, Crowe: Defective bone morphogenic protein signaling underlies hepcidin deficiency in HFE hereditary hemochromatosis. in Hepatology (Baltimore, Md.) 2010
Show all 2 Pubmed References
activation of AMPK (zeige PRKAA1 Antikörper) upregulated Smad6 and Smurf1 (zeige SMURF1 Antikörper) and thereby enhanced their interactions, resulting in its proteosome-dependent degradation of ALK2 (zeige ACRV1 Antikörper).
Results show that high Smad6 expression is correlated with increased risk of metastasis in ER negative breast cancer and that Smad6 determines BMP-regulated invasive behavior of breast cancer cells in a zebrafish xenograft model.
evaluated the role of inherited genetic variation in Langerhans cell histiocytosis susceptibility and identified a novel risk variant in SMAD6
This search revealed that rare mutations that disable one copy of a gene called SMAD6 in combination with a common DNA variant near another gene called BMP2 (zeige BMP2 Antikörper) account for about 7% of infants with midline forms of craniosynostosis.
Single Nucleotide Polymorphisms in SMAD6 gene is associated with brain metastasis in non-small-cell lung cancer
monoubiquitinated SMAD6 impairs the binding affinity of non-modified SMAD6 to the BMP type I receptor. Moreover, UBE2O (zeige UBE2O Antikörper) and SMAD6 cooperated in the regulation of BMP7 (zeige BMP7 Antikörper)-induced adipogenesis
Smad6 indirectly maintains stemness by preventing spontaneous erythropoiesis in hematopoietic stem cells.
Loss of SMAD6 is associated with lung adenocarcinoma.
Congenital cardiovascular malformation is related to genetic variation in SMAD6
Haplotype analysis further revealed that two haplotype blocks within SMAD6 were significantly associated with decreased ovarian cancer risk, as compared to the most common haplotype.
A complex form of acute rheumatic heart disease with tissue hardening is seen in the absence of either Smad-6 (or NKX2-5 (zeige NKX2-5 Antikörper)).
These results indicate that PRIP (zeige NCOA6 Antikörper) is implicated in BMP-induced osteoblast differentiation by the negative regulation of Smad (zeige SMAD1 Antikörper) phosphorylation, through the methylation of inhibitory Smad6
These findings suggest that TNF-alpha (zeige TNF Antikörper) induces valvular and vascular cell calcification, in part, by specifically reducing the expression of a BMP-2 (zeige BMP2 Antikörper) signaling inhibitor, Smad6.
The Smad6 is a novel target of Arkadia (zeige RNF111 Antikörper), and that Arkadia (zeige RNF111 Antikörper) positively regulates BMP signalling via degradation of Smad6, Smad7 (zeige SMAD7 Antikörper) and c-Ski (zeige SKI Antikörper)/SnoN (zeige SKIL Antikörper).
Smad6 inhibits non-canonical TGF-beta1 (zeige TGFB1 Antikörper) signaling by recruiting the deubiquitinase A20 (zeige TNFAIP3 Antikörper) to TRAF6 (zeige TRAF6 Antikörper).
Hepcidin (zeige HAMP Antikörper), Smad6 and Smad7 (zeige SMAD7 Antikörper) mRNA expression is coordinated in a way that it correlates with the activity of the Bmp/Smad (zeige SMAD1 Antikörper) signaling pathway.
Sema7A (zeige SEMA7A Antikörper) positively regulates the production of transforming growth factor (TGF)-beta1 (zeige TGFB1 Antikörper) and Smad6 to facilitate West Nile virus pathogenesis in mice.
Results indicate that peptidyl-prolyl isomerase Pin1 (zeige PIN1 Antikörper) Associates with Smad3 (zeige SMAD3 Antikörper) and Smad6.
Data show that Runx1 (zeige RUNX1 Antikörper), in conjunction with Fli1 (zeige FLI1 Antikörper), Gata2 (zeige GATA2 Antikörper), and Scl (zeige TAL1 Antikörper), directly regulates the expression of Smad6 in the aorta-gonad-mesonephros region in the developing embryo, where hematopoietic stem cells originate.
The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants encoding different isoforms have been found for this gene.
SMAD, mothers against DPP homolog 6
, MAD homolog 6
, Mothers against decapentaplegic, drosophila, homolog of, 6
, SMAD 6
, mothers against DPP homolog 6
, mothers against decapentaplegic homolog 6
, Smad 6
, mad homolog 7
, MAD, mothers against decapentaplegic homolog 6