SMAD6 Antikörper
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- Target Alle SMAD6 Antikörper anzeigen
- SMAD6 (SMAD, Mothers Against DPP Homolog 6 (SMAD6))
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser SMAD6 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA
- Aufreinigung
- purified
- Immunogen
- Purified recombinant fragment of human SMAD6 expressed in E. coli. ,
- Klon
- 5H3
- Isotyp
- IgG1
- Top Product
- Discover our top product SMAD6 Primärantikörper
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- Applikationshinweise
- ELISA: 1:10000, WB: 1:500 - 1:2000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- Ascitic fluid containing 0.03 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- 4°C, -20°C for long term storage
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A new nonsense mutation of SMAD8 associated with pulmonary arterial hypertension." in: Journal of medical genetics, Vol. 46, Issue 5, pp. 331-7, (2009) (PubMed).
: "Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation." in: The Journal of biological chemistry, Vol. 281, Issue 6, pp. 3569-76, (2006) (PubMed).
: "Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1." in: Nature immunology, Vol. 7, Issue 10, pp. 1057-65, (2006) (PubMed).
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A new nonsense mutation of SMAD8 associated with pulmonary arterial hypertension." in: Journal of medical genetics, Vol. 46, Issue 5, pp. 331-7, (2009) (PubMed).
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- Target
- SMAD6 (SMAD, Mothers Against DPP Homolog 6 (SMAD6))
- Andere Bezeichnung
- SMAD6 (SMAD6 Produkte)
- Synonyme
- madh6 antikoerper, madh7 antikoerper, Xsmad6 antikoerper, hst17432 antikoerper, AOVD2 antikoerper, HsT17432 antikoerper, MADH6 antikoerper, MADH7 antikoerper, Madh6 antikoerper, b2b390Clo antikoerper, Smad6-like antikoerper, smad6 antikoerper, wu:fb22g05 antikoerper, SMAD family member 6 antikoerper, SMAD family member 6a antikoerper, smad6 antikoerper, SMAD6 antikoerper, Smad6 antikoerper, smad6a antikoerper
- Hintergrund
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Description: Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members, has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions.Tissue specificity: Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue.
Aliases: MADH6, MADH7, HsT17432, SMAD6
- Molekulargewicht
- 53 kDa
- Gen-ID
- 4091
- HGNC
- 4091
- Pathways
- Chromatin Binding
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