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Our findings provide evidence for a novel crosstalk and a crossregulation between ING1 and ING2 in regulating androgen receptor-mediated transactivation and suggest that ING2 acts as a novel corepressor that inhibits AR signaling, prostate cancer cell growth, and migration.
ING2 may be involved in the repair and regeneration of organs or tissues and is associated with breast and gynecological carcinogenesis.
Results suggest that ING2 acts as a tumor suppressor in osteosarcoma.
It is thought that ING2 gene expression level could contribute to the development of BCC but not be associated with the stage and the prognosis of the tumor.
Decreased expression of ING2 gene is associated with non-small cell lung cancer.
It was concluded that ING2 not only plays an essential role in the growth and invasion of MGC-803 cells but also represents a potential approach to chemosensitization therapy in human gastric cancer.
findings support a model in which PtdIns(5)P functions as a sub-nuclear trafficking factor that stabilizes ING2 at discrete genomic sites
Study establishes ING2 as a novel regulator of spermatogenesis functioning, and provides an animal model to study idiopathic and iatrogenic infertility in men.
Data show that inhibition of ING2 expression accelerates progression of cells from G(1) to S-phase, and is accompanied by a decrease of p21 expression, and that regulation of p21 by ING2 is independent of p53.
expression is downregulated in non-small cell lung carcinoma
sumoylation of ING2 enhances its binding to the Sin3A/HDAC complex and is required to regulate gene transcriptions
The ING1L gene may be involved in basal cell carcinogenesis.
P33ING2 cooperates with p53 to regulate apoptosis via activation of both the mitochondrial/intrinsic and death-receptor/extrinsic apoptotic pathways.
ING2 can act as a cofactor of p300 for p53 acetylation and thereby plays a positive regulatory role during p53-mediated replicative senescence.
The expression of ING2 was down-regulated in 6 of 7 lung cancer cell lines that had a p53 mutation.
Observations suggest that p33ING2 is required for the initial DNA damage sensing and chromatin remodeling in the nucleotide excision repair process.
The data showed that nuclear ING2 expression was significantly reduced in radial growth phase (RGP), vertical growth phase (VGP), and metastatic melanomas compared with dysplastic nevi (P < 0.05).
Deletion of leucine zipper-like (LZL)abrogated the association between ING2 and p53, suggesting that ING2 modulates p53-dependent chromatin remodeling, apoptosis and DNA repair.
molecular modeling and docking of the 5-methylenephosphonate or 5-phosphothionate analogues to the C-terminus PtdInsP-binding region of ING2 revealed a number of complementary surface and electrostatic contacts between the lipids and ING2
the interaction between Alien and the tumor suppressors p33ING1 and p33ING2 reveals a novel cellular protein network
ING2 may play a crucial role in the process of preimplantation embryo development through chromatin regulation.
These findings define a novel function for ING2 in muscle differentiation.
2.0 A resolution structure of the mouse ING2 PHD finger in complex with a histone H3 peptide trimethylated at lysine 4
These data establish the TH-dependent recruitment of transcription factors to ING promoter regions and suggest that differential TR recruitment in response to TH may not be a sufficient indicator for modulating the expression of ING in the tail.
This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis.
, inhibitor of growth 1-like protein
, inhibitor of growth protein 2
, inhibitor of growth family, member 2
, inhibitor of growth family, member 1-like
, inhibitor of growth family, X-linked, pseudogene
, inhibitor of growth family member 2 L homeolog