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In pluripotent cells, Brd2-Brd4 (zeige BRD4 Proteine) occupy Nodal gene regulatory elements (NREs), but only Brd4 (zeige BRD4 Proteine) is required for pluripotency gene expression. Brd4 (zeige BRD4 Proteine) downregulation facilitates pluripotent exit and drives enhanced Brd2 NRE occupancy, thereby unveiling a specific function for Brd2 in differentiative Nodal-Smad2 (zeige SMAD2 Proteine) signalling
BRDs are overexpressed in castration-resistant prostate cancer and that ATAD2 (zeige ATAD2 Proteine) and BRD2 have prognostic value.
The bromodomain and extraterminal domain (BET) family consists of BRDT (zeige BRDT Proteine), BRD2, BRD3 (zeige BRD3 Proteine), and BRD4 (zeige BRD4 Proteine), each containing 2 bromodomains located N-terminal to extraterminal domain, which is located near C-terminus. Data suggest that 10 distinct acylations participate in binding of BET family proteins to histone 4 (oligopeptide fragments used here); C-terminal bromodomains do not cooperatively bind multiple acylation sites.
The identification of RNF43 (zeige RNF43 Proteine) mutations in a distinct subset of intraductal papillary neoplasm of the bile ducts revealed a new molecular role in the pathogenesis of this disease
LRP1B (zeige LRP1B Proteine), BRD2 and CACNA1D (zeige CACNA1D Proteine) are new candidate genes in fetal metabolic programming of newborns exposed to maternal hyperglycemia.
This study implicates BET Brds as important regulators of IkappaB kinase (zeige CHUK Proteine)/NF-kappaB (zeige NFKB1 Proteine)-mediated synovial inflammation of RA and identifies BET proteins as novel therapeutic targets in inflammatory arthritis.
An unexpected role for the bromodomain and extraterminal domain (BET) proteins BRD2 and BRD4 (zeige BRD4 Proteine) in maintaining oncogenic IKK (zeige CHUK Proteine) activity in activated B-cell-like diffuse large B-cell lymphoma.
BET proteins, particularly Brd2 and Brd4 (zeige BRD4 Proteine), may play a key role in the regulation of Nrf2 (zeige GABPA Proteine)-dependent antioxidant gene transcription and are hence an important target for augmenting antioxidant responses in oxidative stress-mediated diseases.
The C-terminal domain of Brd2 is important for chromatin interaction and regulation of transcription and alternative splicing.
A structural basis for BRD2/4-mediated host chromatin interaction and oligomer assembly of Kaposi sarcoma-associated herpesvirus and murine gammaherpesvirus LANA proteins.
these results provided evidence for a novel role of Brd2 in chronic inflammation and insulin (zeige INS Proteine) resistance.
BRD2 acts to augment the boundary function of CTCF (zeige CTCF Proteine) both by limiting the spread or range of enhancer activity and by physically preventing the formation of cross-boundary contacts genome-wide.
Brd2 and Brd4 (zeige BRD4 Proteine) genetic transcription required for Th17 cell development and adaptive immunity.
This study reveals an antagonistic relationship between H2A.Z (zeige H2AFZ Proteine).1ub and BRD2 to regulate the transcriptional balance at bivalent genes to enable proper execution of developmental programs.
BRD2 is involved in the modulation of neuroinflammatory responses through PAI-1 (zeige SERPINE1 Proteine) and via the regulation of epigenetic reader BET protein
DNA demethylation of the Brd2 promoter region induced Brd2 expression during differentiation of 3T3-L1 cells into adipocytes.
Brd2 inhibits adipogenesis via the ERK1/2 signaling pathway in 3T3-L1 adipocytes.
We conclude that Brd2 plays a critical, independent role in regulation of mitogenic response genes
Data show that infection of macrophages with Listeria monocytogenes caused binding of the BET proteins Brd2, Brd3, and, most prominently, Brd4 to the Nos2 promoter.
these results suggest an evolutionarily conserved role for Brd2 in the proper formation and/or patterning of segmented tissues, including the vertebrate CNS, where it acts as a bi-modal regulator of apoptosis, and is necessary, directly or indirectly, for proper expression of genes that pattern the MHB and/or regulate differentiation in the anterior hindbrain.
brd2a on chromosome 19 exhibits both maternal and zygotic contributions to early development and patterning, analogous to the brd2 ortholog in Drosophila.
This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene.
, bromodomain-containing 2
, bromodomain-containing protein 2
, female sterile homeotic-related gene 1
, really interesting new gene 3 protein
, collagen type XI alpha 2
, glutamate-cysteine ligase catalytic subunit
, ring finger protein 3