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Dog (Canine) Polyclonal AIRE Primary Antibody für EIA, IHC (p) - ABIN5553212
Ströbel, Hartmann, Rosenwald, Kalla, Ott, Friedel, Schalke, Kasahara, Tomaru, Marx: Corticomedullary differentiation and maturational arrest in thymomas. in Histopathology 2014
Show all 6 Pubmed References
Human Polyclonal AIRE Primary Antibody für IHC, ELISA - ABIN185643
Niki, Oshikawa, Mouri, Hirota, Matsushima, Yano, Han, Bando, Izumi, Matsumoto, Nakayama, Kuroda, Matsumoto: Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice. in The Journal of clinical investigation 2006
Show all 3 Pubmed References
Human Polyclonal AIRE Primary Antibody für IHC (p), IHC - ABIN249580
Kumar, Laloraya, Wang, Ruan, Davoodi-Semiromi, Kao, She: The autoimmune regulator (AIRE) is a DNA-binding protein. in The Journal of biological chemistry 2001
Cow (Bovine) Polyclonal AIRE Primary Antibody für WB - ABIN2779776
Tao, Kupfer, Stewart, Williams-Skipp, Crowell, Patel, Sain, Scheinman: AIRE recruits multiple transcriptional components to specific genomic regions through tethering to nuclear matrix. in Molecular immunology 2005
Aire transactivates HLA-G gene expression in thymic epithelial cells.
Mutations of the autoimmune regulator gene (AIRE), located on chromosome 21q22.3, are recognized as the cause of a rare monogenic organ-specific autoimmune disorder called autoimmune polyglandular syndrome type 1 (APS-1).
Study demonstrated AIRE to be expressed outside the human thymus in human tonsils cells and shows that AIRE expression within the periphery is not associated with an enriched expression of tissue-restricted antigens. These cells are CD127+ dendritic cells with a mature CCR7+PDL1+ phenotype that express AIRE during their maturation.
AIRE-interactors networks showed that minipuberty and genomic mechanisms interact in shaping thymic sexual dimorphism along the first six months of life.
genetic variation in the autoimmune regulator (AIRE) locus is associated with autoimmune Addison's disease
In a Brazilian cohort, all autoimmune polyendocrine syndrome type 1 patients exhibited mutations in AIRE, and 3 are novel variants.
Meta-analysis and systematic review show that AIRE rs2075876 and rs760426 are significantly associated with an increased risk of rheumatoid arthritis in allelic, dominant, recessive, codominant heterozygous, and codominant homozygous genetic models.
this study shows that Aire controls in trans the production of medullary thymic epithelial cells expressing Ly-6C/Ly-6G
AIRE displays gender-biased thymic expression, with females showing a lower expression compared with males, a finding that could explain the female susceptibility to autoimmune diseases. Review.
DOCK180 has an indispensable role in pregnancy establishment as knocking down Dock180 abrogates pregnancy by a consolidated impact on decidualization and angiogenesis by regulating AIRE nuclear entry.
no significant relation was manifested in our study between the subset age of Myasthenia gravis (MG) and Aire level. Overall, these findings imply circulating Aire might play a role in the imbalance of cTfh and cTfr cells and participate in the pathogenesis of MG.
Data show that autoimmune regulator (AIRE) is important for Candida Albicans yeast and hyphal phagocytosis.
High AIRE expression was detected in 25 patients (58.1%), and significantly associated with the presence of lung metastasis (P = 0.014) and an increased number of forkhead box P3-positive tumor-infiltrating lymphocytes (regulatory T cells) (P = 0.014).
We describe a novel maternally inherited missense variant (c.268T>C, p.Tyr90His) in AIRE, an autoimmune regulator gene on Chromosome 21q22.3. This variant was observed in trans with a paternally inherited variant in AIRE that has previously been classified as pathogenic
this study shows that dominant-negative loss of function arises from a second, more frequent variant within the SAND domain of AIRE
these results also highlight the importance of coordinated action between central tolerance and peripheral tolerance under the common control of Aire
Genetic model analysis showed significant correlations between the TT genotype and the risk of rheumatoid arthritis. Stratification analyses of sex, age, smoking, and alcoholism suggested that the rs878081 polymorphism of the AIRE gene increased rheumatoid arthritis risk among non-smokers. In conclusion, rs878081 polymorphism of AIRE gene increases the risk of RA in a Chinese Han population.
Direct interactions between AIRE, NF-kappaB, and P-TEFb result in efficient transcription of their target genes.
this review shows the role of AIRE in peripheral tolerance
AIRE contributes to autoimmunity in more common organ-specific autoimmune disorders than autoimmune polyendocrine syndrome type-1 (Review)
The results demonstrate that Aire expressed by bone marrow-derived dendritic cells plays an important role in the maintenance of homeostasis by regulating TRA expression and the differentiation of T cell subsets.
Aire plays a role in the process of medullary thymic epithelial cell-thymocyte adhesion
Two-week hindlimb unloading did not alter percentage of CD4+CD8+ cells in thymocytes. Hindlimb unloading reduced cellularity of thymic epithelial cells expressing Aire.
Together, Brg1 and Aire fine-tune the expression of tissue-specific genes at levels that prevent toxicity yet promote immune tolerance
At 5 weeks of age (wk), Aire-/- mice show minimal tissue dysfunction and destruction compared to 7 wk Aire-/-, which exhibit severe dry eye, poor tear secretion, extensive lymphocytic infiltration, reduced functional innervation, and increased vascularization.
This study re-defines requirements for late stage intrathymic alphabetaT-cell development, and demonstrates that Aire controls a CCR6-CCL20 axis that determines the developmental makeup of the intrathymic regulatory T-cell pool.
The Aire fl/fl strain is a suitable model to scrutinize the cell specific function of Aire in distinct biological processes. Medullary thymic epithelial cell (mTEC)-restricted expression of autoimmune regulator (Aire) is essential for establishment of immune tolerance. Aire was also shown to be expressed in cells of hematopietic and reproductive lineages.
Aire associates with spindle-associated proteins in mouse embryonic stem cells. Loss of function analysis revealed that Aire was important for centrosome number regulation and spindle pole integrity specifically in mouse embryonic stem cells.
allelic variants of one AIRE SNP may differentially shape the melanoma antigen-specific T cell repertoire potentially influencing susceptibility to melanoma
In an insulin-promoter model, lack of Aire in medullary thymic epithelial cells, but not in BM-derived APCs, impaired clonal deletion and Treg production. In an Aire-promoter Tg model, both mTECs and BM-derived APCs independently induced clonal deletion without Aire. Treg production was impaired by the lack of Aire in mTECs, but not in BM-derived APCs, suggesting an essential but not universal role for Aire in tolerance.
the maternal microbiome influences Treg differentiation in the thymus of offspring through GPR41-mediated Aire expression
A mutation in LYN, an inhibitory protein tyrosine kinase that is implicated in systemic autoimmunity, combines with an Aire mutation to provoke organ-specific autoimmunity.
Aire exerts multi-faceted autoimmune control that extends to a population of innate-like T cells.
this study shows that Aire enforces immune tolerance by ensuring that distinct autoreactive T cell specificities differentiate into the Treg cell lineage
This finding is the first direct evidence that Aire also plays a role in controlling medullary thymic epithelial cells-thymocyte adhesion.
findings identified two novel stages in the differentiation program of Aire(+) Medullary thymic epithelial cells.
this study shows that Aire and some of its partners, notably those implicated in the DNA-damage response, preferentially localize to and activate long chromatin stretches that are overloaded with transcriptional regulators, known as super-enhancers
Results indicated that AIRE influenced gene expression in germ cell 1 spermatogonial (GC1-spg) cells by acting at multiple levels, including transcription, translation, RNA processing, protein transport, protein localization, and protein degradation, thus setting the foundation in understanding the functional role of AIRE in germ cell biology.
this study provides insight into the complex molecular mechanisms that control the medullary thymic epithelial cells-specific expression of Aire
AIRE, which is phosphorylated on two specific residues near its N terminus, then binds to the F-box protein 3 (FBXO3) E3 ubiquitin ligase. In turn, this SCF(FBXO3) (SKP1-CUL1-F box) complex ubiquitylates AIRE, increases its binding to the positive transcription elongation factor b (P-TEFb), and potentiates its transcriptional activity.
This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED).
, autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein
, autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)
, APECED protein homolog
, autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog
, autoimmune regulator AIRE1a