Checkpoint with Forkhead and Ring Finger Domains Produkte
(Checkpoint with Forkhead and Ring Finger Domains (CHFR))
Kategorien
E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating ubc13-mms2 (ube2n-ube2v2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress (By similarity).
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Ausgewählte Checkpoint with Forkhead and Ring Finger Domains Kategorien
Checkpoint with Forkhead and Ring Finger Domains Antikörper
High quality antibodies with extensive validation data.
Checkpoint with Forkhead and Ring Finger Domains Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene Checkpoint with Forkhead and Ring Finger Domains Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
ELISA, WB, IHC (p), RNAi
Validierungen
- (7)
- (6)
Kat. Nr.
ABIN565913
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
ELISA, WB, IHC
Validierungen
- (3)
Kat. Nr.
ABIN7151005
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
ELISA, WB
Validierungen
- (3)
Kat. Nr.
ABIN527639
Menge
100 μg
Datenblatt
Datenblatt
Empfohlene Checkpoint with Forkhead and Ring Finger Domains ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6234620
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene Checkpoint with Forkhead and Ring Finger Domains Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Mouse
Source
HEK-293 Cells
Validierungen
- (3)
Kat. Nr.
ABIN7564311
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Human
Source
HEK-293 Cells
Validierungen
- (3)
Kat. Nr.
ABIN7553319
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1349312
Menge
10 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren Checkpoint with Forkhead and Ring Finger Domains Produkten
: "Expression level of the mitotic checkpoint protein and G2-M cell cycle regulators and prognosis in gastrointestinal stromal tumors in the stomach." in: Virchows Archiv : an international journal of pathology, Vol. 460, Issue 2, pp. 163-9, (2012) (PubMed).: "CHFR protein regulates mitotic checkpoint by targeting PARP-1 protein for ubiquitination and degradation." in: The Journal of biological chemistry, Vol. 287, Issue 16, pp. 12975-84, (2012) (PubMed).
: "Pathobiologic implications of methylation and expression status of Runx3 and CHFR genes in gastric cancer." in: Medical oncology (Northwood, London, England), Vol. 28, Issue 2, pp. 447-54, (2011) (PubMed).
: "Loss of CHFR in human mammary epithelial cells causes genomic instability by disrupting the mitotic spindle assembly checkpoint." in: Neoplasia (New York, N.Y.), Vol. 10, Issue 7, pp. 643-52, (2008) (PubMed).
: "Mechanism and pathobiologic implications of CHFR promoter methylation in gastric carcinoma." in: World journal of gastroenterology : WJG, Vol. 14, Issue 32, pp. 5000-7, (2008) (PubMed).
: "Molecular analysis of primary gastric cancer, corresponding xenografts, and 2 novel gastric carcinoma cell lines reveals novel alterations in gastric carcinogenesis." in: Human pathology, Vol. 38, Issue 6, pp. 903-13, (2007) (PubMed).
: "Altered expression of the early mitotic checkpoint protein, CHFR, in breast cancers: implications for tumor suppression." in: Cancer research, Vol. 67, Issue 13, pp. 6064-74, (2007) (PubMed).
: "Chfr defines a mitotic stress checkpoint that delays entry into metaphase." in: Nature, Vol. 406, Issue 6794, pp. 430-5, (2000) (PubMed).
Synonyme und alternative Namen zu Checkpoint with Forkhead and Ring Finger Domains
checkpoint with forkhead and ring finger domains (CHFR), checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase (chfr), checkpoint with forkhead and ring finger domains (Chfr), checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase L homeolog (chfr.L), 5730484M20Rik, C230082M18, CHFR, fc43f10, RNF116, rnf116, RNF196, rnf196, si:dkey-69h6.7, wu:fc43f10Bezeichner auf Proteinebene für Checkpoint with Forkhead and Ring Finger Domains
- E3 ubiquitin-protein ligase CHFR
- RING finger protein 196
- checkpoint with forkhead and RING finger domains protein
- checkpoint with forkhead and ring finger domains
- Checkpoint with forkhead and RING finger domains protein
- e3 ubiquitin-protein ligase CHFR-like
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