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Human TNFSF4 Protein expressed in HEK-293 Cells - ABIN1344408
Mestas, Crampton, Hori, Hughes: Endothelial cell co-stimulation through OX40 augments and prolongs T cell cytokine synthesis by stabilization of cytokine mRNA. in International immunology 2005
Data suggest that tumour necrosis factor (zeige TNF Proteine) superfamily 4 (TNFSF4) rs704840 could be the potential systemic lupus erythematosus (SLE) risk factors in the Malaysian population.
House dust mite sublingual immunotherapy downregulated Th2-type immune responses mediated by the TSLP (zeige TSLP Proteine)-OX40L signaling pathway in patients with persistent moderate to severe allergic rhinitis.
OX40 (zeige TNFRSF4 Proteine) and OX40L formed a functional complex, which may facilitate signal transduction from OX40L to OX40 (zeige TNFRSF4 Proteine) and contribute to the pathogenesis of Grave's disease.
The polymorphisms of the TNFSF4 gene may contribute to the susceptibility to pathogenesis of early-Onset Autoimmune Thyroid Diseases and Hypothyroidism of Hashimoto's Thyroiditis.
the SNPs in TNFSF4 and FAM167A-BLK may be involved in asthma and allergic rhinitis gene risk in the Han Chinese cohort.
Given the discovery cohort, functional data, and importance of TNFSF4 in infection clearance, TNFSF4C may associate with outcomes and warrants future studies.
Review/Meta-analysis: TNFSF4 (rs3850641) polymorphisms is not associated with coronary heart disease risk.
Study showed that the A allele of the rs7518045 and haplotype rs3861950C-rs17346501C-rs7518045A-rs1234313G in the TNFSF4 gene were associated with decreased risk for myocardial infarction in a Chinese Han population.
Data indicate that soluble OX40 (zeige TNFRSF4 Proteine) and sOX40L plasma levels are increased in early rheumatoid arthritis patients.
Report role of TNFSF4 genetic variants in confering risk of systemic lupus erythematosus in Chinese population.
These data support the hypothesis that the Ox40 (zeige TNFRSF4 Proteine)/Ox40L pathway drives cellular and humoral autoimmune responses during lupus nephritis in NZB/W F1 mice and emphasize the potential clinical value of targeting this pathway in human lupus.
The OX40L expression is induced on the bronchiolar progenitors for the antiviral immunity during the infectious process. However, these defense-like host responses lead to more extensive infection with the influenza virus owing to the induced OX40L with alpha-2,6 sialic acid modification, which augments the interaction with the viral hemagglutinin (zeige HA Proteine).
bone marrow-derived mast cell (BMMC)-exosomes facilitated the differentiation of naive CD4 (zeige CD4 Proteine)+ T cells to Th2 cells by ligation of OX40L and OX40 (zeige TNFRSF4 Proteine) between BMMC-exosomes and CD4 (zeige CD4 Proteine)+ T cells and represents a novel mechanism of cell-to-cell communication
Rhinovirus infection interferes with induction of tolerance to aeroantigens through OX40 ligand, thymic stromal lymphopoietin (zeige TSLP Proteine), and IL-33 (zeige IL33 Proteine)
Anti-OX40L mAb could prolong secondary heart allograft survival based on CD40 (zeige CD40 Proteine)/CD40L (zeige CD40LG Proteine) and LFA-1 (zeige ITGAL Proteine)/ICAM-1 (zeige ICAM1 Proteine) blockade.
intestinal Th2 priming is initiated by an autocrine/paracrine acting CD4 (zeige CD4 Proteine)(+) Th cell-intrinsic IL-4 (zeige IL4 Proteine) program that is controlled by DC OX40L, and not by NKT (zeige CTSL1 Proteine), gammadelta T, or ILC (zeige CCL27 Proteine) cells.
a critical role of OX40L presented by the activated basophils to initiate Th2 responses in an allergic asthma model, implicating OX40 (zeige TNFRSF4 Proteine)-OX40L signaling as a potential therapeutic target in the treatment of allergic airway inflammation.
The majority of transferred CD40L (zeige CD40LG Proteine)(-/-) T cells in Rag-1 (zeige RAG1 Proteine)(-/-) B6 mice were differentiated to CD44 (zeige CD44 Proteine)(high).
OX40 (zeige TNFRSF4 Proteine)-OX40L interaction regulates the expression of NFATc1 (zeige NFATC1 Proteine), which may play a critical role in atherosclerotic plaque formation, and may therefore have implications with pathophysiology of atherosclerosis.
The need for additional immune suppression in the intestine reflects commensal microbe-driven T-cell activation through the accessory costimulation molecules ICOSL (zeige ICOSLG Proteine) and OX40L in B7 deprived mice.
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF4/OX4. It is found to be involved in T cell antigen-presenting cell (APC) interactions. In surface Ig- and CD40-stimulated B cells, this cytokine along with CD70 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells.
tumor necrosis factor (ligand) superfamily, member 4 (tax-transcriptionally activated glycoprotein 1, 34kDa)
, tumor necrosis factor (ligand) superfamily, member 4
, tumor necrosis factor ligand superfamily member 4
, OX40L protein
, CD134 ligand
, OX40 antigen ligand
, TAX transcriptionally-activated glycoprotein 1
, glycoprotein Gp34
, tax-transcriptionally activated glycoprotein 1 (34kD)
, OX40 ligand
, atherosclerosis 1
, tax-transcriptionally activated glycoprotein 1 ligand