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anti-Human NLRP3 Antikörper:
anti-Mouse (Murine) NLRP3 Antikörper:
anti-Rat (Rattus) NLRP3 Antikörper:
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Human Polyclonal NLRP3 Primary Antibody für ICC, IF - ABIN4340123
Wang, Pan, Zhang, Wang, Kong: Quercetin and allopurinol ameliorate kidney injury in STZ-treated rats with regulation of renal NLRP3 inflammasome activation and lipid accumulation. in PLoS ONE 2012
Show all 31 Pubmed References
Human Polyclonal NLRP3 Primary Antibody für ELISA, ICC - ABIN4340113
Chamaillard, Girardin, Viala, Philpott: Nods, Nalps and Naip: intracellular regulators of bacterial-induced inflammation. in Cellular microbiology 2003
Show all 11 Pubmed References
Human Monoclonal NLRP3 Primary Antibody für IHC, IP - ABIN1169100
Zhou, Tardivel, Thorens, Choi, Tschopp: Thioredoxin-interacting protein links oxidative stress to inflammasome activation. in Nature immunology 2010
Show all 8 Pubmed References
Human Polyclonal NLRP3 Primary Antibody für IF (p), IHC (p) - ABIN1386361
Zendedel, Johann, Mehrabi, Joghataei, Hassanzadeh, Kipp, Beyer: Activation and Regulation of NLRP3 Inflammasome by Intrathecal Application of SDF-1a in a Spinal Cord Injury Model. in Molecular neurobiology 2015
Show all 7 Pubmed References
Human Monoclonal NLRP3 Primary Antibody für CyTOF, FACS - ABIN4898963
Hu, Zhang, Wang, Mao, Lv, Yuan, Huang, Ding, Xie, Liu: Knockout of Ccr2 alleviates photoreceptor cell death in rodent retina exposed to chronic blue light. in Cell death & disease 2016
Show all 6 Pubmed References
Human Polyclonal NLRP3 Primary Antibody für IHC, IHC (p) - ABIN4340115
Abdul-Sater, Koo, Häcker, Ojcius: Inflammasome-dependent caspase-1 activation in cervical epithelial cells stimulates growth of the intracellular pathogen Chlamydia trachomatis. in The Journal of biological chemistry 2009
Show all 5 Pubmed References
Human Monoclonal NLRP3 Primary Antibody für IHC, IHC (fro) - ABIN4340117
Shio, Tiemi Shio, Eisenbarth, Savaria, Vinet, Bellemare, Harder, Sutterwala, Bohle, Descoteaux, Flavell, Olivier: Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases. in PLoS pathogens 2009
Show all 3 Pubmed References
Human Polyclonal NLRP3 Primary Antibody für WB - ABIN3043571
Xue, Wang, Du, Zhu: Maternal obesity induces gut inflammation and impairs gut epithelial barrier function in nonobese diabetic mice. in The Journal of nutritional biochemistry 2014
Show all 2 Pubmed References
Human Polyclonal NLRP3 Primary Antibody für IHC (p), IHC - ABIN251577
Wei, Chen, James, Stone, Chamley: IL-1 beta but not the NALP3 inflammasome is an important determinant of endothelial cell responses to necrotic/dangerous trophoblastic debris. in Placenta 2015
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Human Polyclonal NLRP3 Primary Antibody für IHC (p), WB - ABIN652504
Jhang, Lu, Ho, Cheng, Yen: Protective Effects of Catechin against Monosodium Urate-Induced Inflammation through the Modulation of NLRP3 Inflammasome Activation. in Journal of agricultural and food chemistry 2015
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Similar carrier rate of the NLRP3-Q703K allele among patients with manifestations of autoinflammatory disease and an ethnically matched control group suggest that this variant, does not determine the clinical phenotype.
Saturated faty acids activated the NLRP3 inflammasome and stimulated the secretion of IL-1beta (zeige IL1B Antikörper) cytokine, while polyunsaturated fatty acids were mainly inhibitors.
The results lead to the hypothesis that NLRP3-inflammasome and associated IL-1beta (zeige IL1B Antikörper) release have potential as CVR biomarkers, particularly in post-AMI (zeige CFD Antikörper) patients with otherwise low risk scores.
findings suggest that beside the RLR (zeige DHX58 Antikörper) pathway, RNase L (zeige RNASEL Antikörper) cleavage products can also activate the NLRP3-inflammasome pathway, which requires DHX33 (zeige DHX33 Antikörper) (DExD/H-box helicase) and the mitochondrial adaptor protein MAVS (zeige MAVS Antikörper).
Collectively, our findings show that inhibition of the NLRP3 inflammasome decreases foam cell formation of THP-1 (zeige GLI2 Antikörper) macrophages via suppression of ox-LDL uptake and enhancement of cholesterol efflux, which may be due to downregulation of CD36 (zeige CD36 Antikörper) expression and upregulation of ABCA1 (zeige ABCA1 Antikörper) and SR-BI (zeige SCARB1 Antikörper) expression, respectively.
This review surveys the involvement of the NLRP3 inflammasome in various signalling pathways and highlight different aspects of their influence on diabetic nephropathy. [review]
Data suggest that aggregates of amyloid beta(1-40) induce excessive generation of reactive oxygen species, MAPK (zeige MAPK1 Antikörper)/NFkappaB (zeige NFKB1 Antikörper) signaling activation, and NLRP3 inflammasome activation in retinal pigment epithelial cells mimicking changes seen in age-related macular degeneration; this mechanism is dependent on NADPH oxidase (zeige NOX1 Antikörper).
results indicate a possible role of the NLRP3 inflammasome and its genetic variants in the pathogenesis of atherosclerosis.
Our results show that Tim-3 (zeige HAVCR2 Antikörper) is a critical negative regulator of NLRP3 inflammasome and provides a potential target for intervention of diseases with uncontrolled inflammasome activation.
IL-27 (zeige IL27 Antikörper) increased NLRP3 inflammasome activation in monocytes with enhanced release of IL-1 beta (zeige IL1B Antikörper).
Andrographolide can inhibit ovalbumin (zeige OVA Antikörper)-induced asthma with a possible mechanism of ROS (zeige ROS1 Antikörper) elimination, thus negatively regulate NF-kappaB (zeige NFKB1 Antikörper) and NLRP3 inflammasome activation.
mitochondrial dysfunction contributed to NLRP inflammasome activation and was triggered by Ang II (zeige AGT Antikörper) via AT1R (zeige AGTRAP Antikörper).
Data suggest that advanced glycation end products act on bone marrow-derived macrophages to impair Nlrp3 inflammasome-mediated innate immunity.
blockade of RAGE (zeige AGER Antikörper) inhibited AGE-RAGE (zeige AGER Antikörper)-induced ROS (zeige ROS1 Antikörper) production and attenuated TXNIP (zeige TXNIP Antikörper)-NLRP3 activation, thus reducing the levels of the pro-inflammatory cytokine IL-1beta (zeige IL1B Antikörper) and consequently attenuating abnormal kidney function and vascular endothelial dysfunction
In the absence of NLRP3 inflammasome, prolonged stress does not provoke depressive behavior or microglial activation compared to controls.
NLRP3 inflammasome activation in HSCs may serve as an early mechanism to turn on the inflammatory response and thereby instigate liver fibrosis during Schistosoma J infection
Nlrp3 regulated caspase-8 (zeige CASP8 Antikörper) activation downstream of multiple pathways involving TNFR (zeige TNFRSF1A Antikörper), CD95 (zeige FAS Antikörper) and non-death receptor apoptosis triggered by etoposide. Second, the impact of K+ on epithelial cell apoptosis and the formation of the non-canonical NLRP3/ASC (zeige STS Antikörper)/caspase-8 (zeige CASP8 Antikörper) platform implies that multiple mitochondrial cell death pathways may converge on a single mechanism to that involving NLRP3.
sestrin2 has a role in suppressing sepsis by inducing mitophagy and inhibiting NLRP3 activation in macrophages
the agonists inhibited the priming of inflammasome activation. In vivo data also showed that LXRs agonist prevented NLRP3-dependent peritonitis. In conclusion, LXRs agonists are identified to potently suppress NLRP3 inflammasome and the regulation of LXRs signaling is a potential therapeutic for inflammasome-driven diseases.
The reactive oxygen species-dependent activation of endothelial Nlrp3 inflammasomes by hyperglycemia may be an important initiating mechanism to cause endothelial dysfunction.
This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data\; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.
NACHT, LRR and PYD domains-containing protein 3
, cold autoinflammatory syndrome 1
, NLR family, pyrin domain containing 3
, NACHT, LRR and PYD domains-containing protein 3-like
, NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3
, NACHT, LRR and PYD containing protein 3
, PYRIN-containing APAF1-like protein 1
, caterpiller protein 1.1
, cold autoinflammatory syndrome 1 protein
, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3
, NACHT/LRR/pyrin domain-containing protein 3
, cold autoinflammatory syndrome 1 homolog
, cold autoinflammatory syndrome 1 protein homolog
, mast cell maturation inducible protein 1
, mast cell maturation-associated-inducible protein 1
, NLR family pyrin domain containing 3