anti-CCL5 (CCL5) Antikörper

Human Chemokine (C-C Motif) Ligand 5 (CCL5) Interaktionspartner

1. The secretion of CCL5 and CCL2 was stimulated in undifferentiated and decidualized ESCs by the combination of TNF-alpha and IFN-gamma under non-apoptotic as well as apoptotic (with Fas-stimulation in parallel) conditions. TNF-alpha or IFN-gamma alone did not have this effect. The stimulatory influence of TNF-alpha plus IFN-gamma on CCL5 and CCL2 in ESCs was also seen on the transcriptional level.

2. this study shows that EMSY is increased and activates TSLP & CCL5 expression in eosinophilic esophagitis

3. These CCL5 derivatives may now be tested against several inflammation-related pathologies where the CCL5:CCR5 axis plays a relevant role.

4. The CCL5 In1.1T/C polymorphism may modulate pulmonary early-onset tuberculosis risk.

5. We use CPRC prostate cancer model and demonstrate that endothelial cells secrete large amount of CCL5 and induces autophagy by suppressing AR expression in prostate cancer cell lines. Consequently, elevated autophagy accelerates focal adhesions proteins disassembly and promoted prostate cancer invasion. Inhibition of both CCL5/CCR5 signaling and autophagy significantly reduces metastasis in vivo

6. CCL5, from endothelial cells, acts in a paracrine fashion on triple-negative breast cancer (TNBC) cells to enhance their migration, invasion, and metastasis. CCL5, in turn, accelerates TNBC cell secretion of PAI-1 and promotes TNBC cell metastasis, thus forming a positive feedback loop. Moreover, this enhanced metastatic ability is reversible and dependent on CCL5 signaling via the chemokine receptor, CCR5.

7. high concentration of plasma CCL5 may promote EMT of breast cancer cells. Plasma CCL5 could be a promised candidate to predict chemotherapy response in NCT of LABC.

8. The polymorphism of CCR1 rs3733096 and CCL5 rs3817656 are associated with spontaneous clearance of hepatitis C virus in Chinese Han population.

9. Our results suggested that the CCL5 level was influenced collectively not only by the genotypes of -403G>A SNP and bacillary load but also by the treatment. Thus, CCL5 may be considered for the development of a diagnostic marker and also as an indicator of recovery.

10. serum levels in active vitiligo significantly elevated compared to those in stable vitiligo patients

11. these findings collectively indicate that TGF-beta regulates CCL5 expression in a stage-dependent manner during breast cancer progression

12. KLF5-regulating cancer-associated fibroblasts affect gastric cancer cells progression by CCL5 secretion and activation of CCR5.

13. Data show that plasminogen activator inhibitor-1 (PAI-1) and chemokine CCL5 (CCL5) overexpression promoted cell proliferation and migration in breast cancer cells.

14. Among infants with lower CCL5 levels, the Haemophilus-dominant microbiota profile was associated with a higher risk of intensive care use and hospital length-of-stay >/=3 days compared to the Moraxella-dominant profile. Conversely, among those with higher CCL5 levels, there were no significant associations between the microbiota profiles and these severity outcomes

15. The current study suggests that TLR3 signaling induces CCL5 expression via NF-kappaB and IRF3 in bile duct cells, and this pathway may be involved in the pathogenesis of BA.

16. Study demonstrates that increased CCL5 expression was restricted to human mesenchymal glioblastoma (GBM) and suggests that CCL5 functions in an autocrine growth-promoting circuit, and establish a new receptor responsible for CCL5 function in mesenchymal glioblastoma cells.

17. Study showed that bone stromal cells promoted prostate cancer progression through the secretion of CCL5. In vitro co-culture of bone stromal cells with prostate cancer cells induced the expression of CCL5, which promoted prostate cancer cell migration. CCL5 was found to have a key role in the progression of prostate cancer in the bone metastasis microenvironment.

18. identifies the essential role of the chemoattractive cytokine CCL5 for liver disease progression and especially hepatocellular carcinoma development

19. Breast cancer cell CCL5 mediates bone marrow independent angiogenesis via paracrine signaling.

20. the present study has demonstrated a novel pathway involving CCl5/CCR1/beta-catenin/Slug, via which human Mesenchymal stem cells promotes colorectal cancer development.

Mouse (Murine) Chemokine (C-C Motif) Ligand 5 (CCL5) Interaktionspartner

1. the results show that Broadleaf Mahonia is a novel effective antiinflammatory herb in vitro and ex vivo, and that CCL5 may be closely associated with Granulomatous lobular mastitispathogenesis

2. miR-155 enhances venous neointima formation through the autocrine and paracrine effects of smooth muscle-like cell-derived RANTES in a nuclear factor kappaB-dependent manner in arteriovenous shunts.

3. Macrophage subtypes enhanced the osteogenesis in transwell setting and the transition from M1 to M2 was associated with an increase in bone anabolic factors CCL2/MCP-1, CCL5/RANTES and IGF-1 in vitro.

4. Taken together, our data suggest that CCR5 regulates insulin signaling in hypothalamus which contributes to systemic insulin sensitivity and glucose metabolism.

5. identifies the essential role of the chemoattractive cytokine CCL5 for liver disease progression and especially hepatocellular carcinoma development

6. Breast cancer cell CCL5 mediates bone marrow independent angiogenesis via paracrine signaling.

7. Studied the effects of CCL5-CCR5 interactions in breast cancer metabolism, and findings suggest that CCL5-CCR5 interactions in the tumor microenvironment modulate metabolic events during tumor onset to promote tumorigenesis.

8. RANTES levels were associated with TMS measures of cortical synaptic excitability, but not with long-term potentiation (LTP)-like plasticity.

9. study found that the inflammatory chemokine CCL5 is mostly retained (75%) during the resolution of zymosan A peritonitis in mice; CCL5 exerts a novel proresolving role on macrophages when acting in concert with apoptotic PMN-expressed D6.

10. A robust up-regulation of RANTES within the brain was seen in a mouse model of tick-borne encephalitis.

11. CCL5 paradoxically limits macrophage accumulation in the injured kidney during renin angiotensin system (RAS) activation by constraining the proinflammatory actions of CCL2.

12. This study showed that RANTES is important in the regulation of vascular dysfunction through modulation of perivascular inflammation.

13. IL-6 Mediates Macrophage Infiltration after Irradiation via Up-regulation of CCL2/CCL5 in Non-small Cell Lung Cancer

14. Blocking antibodies against RANTES and eotaxin reduced the infiltration of CD4(+) and CD8(+) T cells into the nigra, attenuated nigral expression of proinflammatory molecules, and suppressed nigral activation of glial cells. These findings paralleled dopaminergic neuronal protection, normalized striatal neurotransmitters, and improved motor functions in MPTP-intoxicated mice.

15. CCL5 deficiency resulted in reduced neointima formation after carotid artery injury and thrombosis.

16. RANTES produced by renal tubular cells act as a key chemokine in acute kidney injury and HIF-1alpha regulated LncRNA-PRINS might be involved in RANTES production.

17. Mycobacterium chelonae activates the gene expressions of chemokine (C-C motif) ligand 2 (CCL2) and CCL5 in murine bone marrow-derived macrophages and in vivo mouse model.

18. Neutralization of circulating RANTES decreased liver neutrophilic infiltration

19. CCL5 signaling through CCR5 may increase platelet counts during physiological stress.

20. An intriguing finding was that S1P induced c-Fos-inhibited CCL5 directly and also indirectly through inhibition of the IFN-beta amplification loop

Pig (Porcine) Chemokine (C-C Motif) Ligand 5 (CCL5) Interaktionspartner

1. These results represent an important molecular mechanism whereby H. parasuis induced RANTES in the inflammatory response.

2. Foot-and-mouth disease virus leader proteinase inhibits dsRNA-induced RANTES transcription.

3. we cloned the nucleotide sequence of the 5'-flanking region of the porcine RANTES (poRANTES) gene and characterized the regulatory elements that activate transcription

4. The Toll-like receptor signaling pathway is involved in porcine reproductive and respiratory syndrome virus-induced RANTES activation.

5. These results suggest that porcine RANTES can play an important role in xenotransplant rejection, through participating in the interaction between porcine endothelial cells and human monocytes.

Cow (Bovine) Chemokine (C-C Motif) Ligand 5 (CCL5) Interaktionspartner

1. CCL5 but not CCL2 mainly attract bovine classical monocytes and promote their differentiation into LPS-hypo-responsive macrophages.

2. decrease in sensitivity of HIV variants to RANTES neutralization during the course of progressive infection, but not during follow-up of long term survivors; data suggest a role for RANTES neutralization sensitivity of HIV-1 in AIDS pathogenesis

Guinea Pig Chemokine (C-C Motif) Ligand 5 (CCL5) Interaktionspartner

1. In the pathogenesis of allergic rhinitis, substance P induces expression of RANTES in nasal mucosa.

Rhesus Monkey Chemokine (C-C Motif) Ligand 5 (CCL5) Interaktionspartner

1. CCL3, CCL4 and CCL5 gene expression was evaluated in response to simian-human immunodeficiency virus (SHIV) infection in a rhesus macaque model.