anti-Chemokine (C-C Motif) Ligand 3-Like 1 (CCL3L1) Antikörper

Human Chemokine (C-C Motif) Ligand 3-Like 1 (CCL3L1) Interaktionspartner

1. We identified genes harboring CNVs that are highly differentiated between PM and global populations, indicating that these genes are predominantly enriched in immune responses and defense functions, including APOBEC3A_B, beta-defensin genes, and CCL3L1, followed by other biological functions, such as drug and toxin metabolism and responses to radiation

2. Characterization of CCL3L1 CNVs with droplet digital PCR methodology highlighted specific CN genotypes in a French family sample. A copy number polymorphism of a rheumatoid arthritis (RA) candidate gene was quantified, and its significant association with RA was revealed in a Tunisian sample.

3. Studied copy number variation of the CCL3L1 gene in contributing to the host variation in susceptibility and response to HIV infection by analyzing a sub-Saharan African cohort.

4. no evidence for an influence of variation in genes coding for MIP-1alpha or CCR5 individually or together in susceptibility to clinically active TB

5. Studies indicate beta-defensins (DEFB4, DEFB103, DEFB104), chemokine ligand 3 like 1 (CCL3L1), Fc gamma receptor 3B (FCGR3B), and complement component C4 (C4) for copy number variation in disease association.

6. The number of CCL3L1 gene copies does not have a role in susceptibility to KD or CALs nor with IVIG resistance in Korean KD patients.

7. The results do not support involvement of the CCL3L1 copy number variants in rheumatoid arthritis susceptibility.

8. The data show no statistically significant association of MIP-1alpha protein levels with copy number. However, there was a significant correlation between copy number and CCL3L1:CCL3 mRNA ratio.

9. Examined a Zimbabwean study population for an association of CCL3L CNV with HIV status, progression and survival. Found no association between four CCL3L CNV strata and HIV status , CD4 T-cell count, viral load , or CCL3 protein levels.

10. Studied the copy number variation of the chemokine gene CCL3L1 with susceptibility to malaria. We identified a high level of copy number haplotype diversity and find some evidence for an association of low CCL3L1 copy number with protection from anaemia.

11. liver transplant recipients with high copy number of CCL3L1 gene had a significant higher risk of acute rejection

12. Copy number of CCL3L1 may influence asthma risk by modulating IL-10 expression

13. The CCR5-HHD haplotype, a known genetic determinant of increased susceptibility to HIV-AIDS, and a high copy number of CCL3L1, a known genetic determinant of enhanced CCL3/CCL3L1 chemokine expression, each associated with presence of tuberculosis.

14. CCL3L1 copy number variation has a role in susceptibility to HIV-1 infection

15. Although CCL3L1 copy number is enriched in uninfected Caucasians, in HIV-1-infected individuals CCL3L1 copy number did not correlate either with long-term nonprogression or with CD4 cell count or viral load in chronic progressors.

16. The CCL3L1-CCR5 axis may play an important role in Kawasaki Disease pathogenesis. In addition to clinical and laboratory parameters, genetic markers may also predict risk of CAL and resistance to IVIG.

17. Studies indicate that complete phenotypic impact requires dissecting the combinatorial genomic complexity posed by various proportions of distinct CCL3L and CCL4L genes among individuals.

18. The association between gene dosage in the gene encoding FCGR3B with the risk of developing autoimmune diseases and whether the observed associations are modified by the gene dosage in CCL3L1 are reported.

19. higher level of expression at systemic level is associated with protection from HIV-1 infection in women from Benin

20. Lower CCL3L1 gene copy number compared to the population median is associated with chronic hepatitis C. Copy number variation of host genes represents a novel class of genetic diversity associated with viral hepatitis.

Rhesus Monkey Chemokine (C-C Motif) Ligand 3-Like 1 (CCL3L1) Interaktionspartner

1. Copy numbers of CCL3L1 in rhesus macaque trios (sire, dam, and offspring) were consistent with Mendelian inheritance