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Human Polyclonal CCL2 Primary Antibody für ELISA, WB - ABIN3042598
Li, Hou, Zhang, Chen, Liu, Feng, Liu, Shan, Wang, Zhou, Tian, Xie: Advanced oxidation protein products accelerate renal fibrosis in a remnant kidney model. in Journal of the American Society of Nephrology : JASN 2007
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Human Monoclonal CCL2 Primary Antibody für ELISA, FACS - ABIN4288765
Chen, Jiao, Jiang, Wan, Li, Li, Xu, Zhou, Xu, Xiao: T-box transcription factor Brachyury in lung cancer cells inhibits macrophage infiltration by suppressing CCL2 and CCL4 chemokines. in Tumour biology 2015
Show all 11 Pubmed References
Human Polyclonal CCL2 Primary Antibody für BP, ICC - ABIN446462
Fet, Fiebeler, Klinge, Park, Barth, Thepen, Tolba: Reduction of activated macrophages after ischaemia-reperfusion injury diminishes oxidative stress and ameliorates renal damage. in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2012
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Mouse (Murine) Polyclonal CCL2 Primary Antibody für IF (p), IHC (p) - ABIN737676
Guo, Feng, Yao, Sun, Zhu: Transplantation of endothelial progenitor cells in treating rats with IgA nephropathy. in BMC nephrology 2014
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Human Polyclonal CCL2 Primary Antibody für ELISA, IHC - ABIN6263169
Wang, Sun, Li, Deng, Zeng, Tao, Wang, Guan, Zhao: Urinary MCP-1、HMGB1 increased in calcium nephrolithiasis patients and the influence of hypercalciuria on the production of the two cytokines. in Urolithiasis 2016
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Mouse (Murine) Monoclonal CCL2 Primary Antibody für FACS, IHC (p) - ABIN2191758
Zoja, Liu, Donadelli, Abbate, Testa, Corna, Taraboletti, Vecchi, Dong, Rollins, Bertani, Remuzzi: Renal expression of monocyte chemoattractant protein-1 in lupus autoimmune mice. in Journal of the American Society of Nephrology : JASN 1997
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Mouse (Murine) Monoclonal CCL2 Primary Antibody für FACS, IHC (p) - ABIN2191759
Kimura, Sumiyoshi, Samukawa, Satake, Sakanaka: Facilitating action of asiaticoside at low doses on burn wound repair and its mechanism. in European journal of pharmacology 2008
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Mouse (Murine) Monoclonal CCL2 Primary Antibody für IA, IHC - ABIN452068
Kajii, Suzuki, Kashihara, Kobayashi, Kubo, Miyamoto, Yuuki, Yamamoto, Nakae: Prevention of excessive collagen accumulation by human intravenous immunoglobulin treatment in a murine model of bleomycin-induced scleroderma. in Clinical and experimental immunology 2011
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Human Polyclonal CCL2 Primary Antibody für WB - ABIN966546
Gosling, Slaymaker, Gu, Tseng, Zlot, Young, Rollins, Charo: MCP-1 deficiency reduces susceptibility to atherosclerosis in mice that overexpress human apolipoprotein B. in The Journal of clinical investigation 1999
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Human Monoclonal CCL2 Primary Antibody für ELISA, WB - ABIN966545
Yoshimura, Yuhki, Moore, Appella, Lerman, Leonard: Human monocyte chemoattractant protein-1 (MCP-1). Full-length cDNA cloning, expression in mitogen-stimulated blood mononuclear leukocytes, and sequence similarity to mouse competence gene JE. in FEBS letters 1989
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High CCL2 is associated with IgA Nephropathy.
A significant relationship between the content of monocytic chemoattractant protein-1 and C-reactive protein in young children with pyelonephritis against the background of reflux was established.
These results indicate that IH stress down-regulates the miR-452 in adipocytes, resulting in increased levels of RETN, TNFalpha, and CCL2 mRNAs, leading to insulin resistance in SAS patients.
sCD163, CCL2, and CXCL10 are associated with activation of macrophages and may have a serious impact on overall survival in patients with idiopathic pulmonary fibrosis .
Serum MCP-1 and TGF-beta1 levels increased in polymyositis/dermatomyositis patients.
Study found that PA28gamma enhanced the ability of oral squamous cell carcinoma (OSCC) cells to promote the migration, invasion, and tube formation of HUVECs and promoted tumor-induced angiogenesis in xenograft mice models in vivo. Expression and secretion of IL-6 and CCL2 were dependent on PA28gamma expression. In addition, IL-6, CCL2 and PA28gamma expressions were correlated in a clinical OSCC cohort.
The relative expression of IL1B and CCL2 was higher in coronary artery disease patients than in normal controls.
The anaplastic thyroid carcinoma produce CCL2 basally and after cytokines stimulation, with an extremely variable pattern of modulation, suggesting different types of deregulation in the chemokine modulation.
IL-10 increase after the first trimester is associated with reduced MCP-1 level in normal weight, but not in obese, mothers.
Blocking androgen receptor signaling in cancer-associated fibroblasts -like cells increases prostate cancer cell migration mediated by increased secretion of CCL2 and CXCL8.
No association was observed between the CCL2 rs1024611 polymorphism and benign prostatic hyperplasia in Chinese patients.
Oligo-Fucoidan supplementation increases cancer cell death and attenuates the adverse effects induced by etoposide that decreases production of the pro-inflammatory cytokine IL-6 and chemokine CCL2/MCP-1.
NFAT5-knockout mouse FLSs also showed decreased expressions of TF and CCL2.
The -2518 A/G polymorphism of the monocyte chemoattractant protein-1 as a candidate genetic predisposition factor.
Study findings indicate a potential role for serum level of MCP-1 in combination with CTRP3 and CTRP9 as a diagnostic and prognostic tool in type 2 diabetes (T2D) and coronary artery disease as a complication of T2D in Egyptian postmenopausal female patients. Negative correlation between MCP-1 and CTRP9 proposes that the anti-inflammatory action of CTRP9 results from reducing MCP-1 production.
We found that pro-inflammatory cytokines IL-6 and CCL2 suppressed PER2 gene expression. Mechanistic studies further revealed that IL-6/STAT3/NFkappaB p50 and CCL2/PI3K/AKT signaling pathways suppressed PER2 gene expression in both phenotypically normal MCF-10A cells as well as MCF-7 breast cancer cells.
the patterns of HBP regulation of the expression of the adhesion molecular VCAM-1 were similar to those seen in MCP-1 after pretreatment with inhibitors.
Serum MCP-1 expression was significantly decreased in patients with UGIB and correlated with blood lipid level.
The aim was to determine the performance of urine EGF, MCP-1 or their ratio at baseline as biomarkers to predict complete remission, and the relationship of these mediators with subsequent renal function 24months later in primary glomerulonephritis.
MCP-1 is independently associated with coronary artery atherosclerosis among emergency department patients with chest pain.
study provides the first evidence to our knowledge that chronic inflammation inhibits reparative fibroblast activation and generates an unfavorable cardiac-healing environment through Ccl12-dependent mechanisms
Combined treatment of PA and LPS in RAW264.7 cells mimics the situation of diabetes with obesity that has higher level of PA and LPS, MAPK/TLR4/ MCP-1 might be potential therapeutic targets for diabetes with obesity.
work demonstrates that MCP-1 has a role in PTH's catabolic effects on bone including monocyte and macrophage recruitment, osteoclast formation, bone resorption, and cortical and trabecular bone loss.
Adipose tissue MCP1 deficiency attenuates high fat diet-enhanced pulmonary metastasis of Lewis lung carcinoma.
These data provide a direct link between TRPML2 activation, CCL2 release and stimulation of macrophage migration in the innate immune response.
High CCL2 expression promotes breast cancer lung metastasis.
results showed elevated expression of Syk in neutrophils and CD11c + DC which was linked with increased IL-6/MCP-1 in CD11c + DCs, and iNOS, NOX2 and nitrotyrosine in neutrophils during sepsis-induced acute kidney injury.
CXCL1, CXCL2 and CCL2 binding to the glomerular endothelial glycocalyx appears differentially mediated by specific Heparan sulfate domains.
Targeting a reduction of MCP-1 opens the door to a better understanding of the mechanistic consequences of ceramide accumulation.
CCL2 played important roles in regulating platelet function and arterial thrombosis through the PKCalpha-P38MAPK-HSP27 pathway.
these results suggested that the IL-1beta-induced recruitment of monocyte/macrophage lineage cells to inflamed synovial membranes in TMJ was further augmented by the cell-cell interaction-induced secretion of MCP-1 from the inflammation site, possibly resulting in prolonged inflammatory responses in TMJ synovial tissue.
NOX4 is induced in early alcoholic liver injury and regulates CCR2/CCL2 mRNA stability thereby promoting recruitment of inflammatory cells and production of proinflammatory cytokines.
Ccl2-Ccr2 signaling recruits a distinct fetal microchimeric population that rescues delayed maternal wound healing.
itration reduced the potential of CCL2 to stimulate monocyte migration in diffusion gradient chemotaxis assays (p < 0.05). This was consistent with a trend towards reduced affinity of the nitrated chemokine for its cognate receptor CCR2b.
CCL2 enables the prolonged Mesenchymal stem cells-T cell interactions needed for sufficient suppression of autoreactive T cells
The data highlight Klf4 as an essential MCPIP1-dependent modulator of innate immunity that protects against excessive and self-destructive inflammation.
a novel mechanism that contributes to the EMT and metastatic phenotype observed in a subset of ADT-resistant prostate cancer, where the CCL2 is stimulated through the inactivated of AR-mediated SPDEF.
Macrophage subtypes enhanced the osteogenesis in transwell setting and the transition from M1 to M2 was associated with an increase in bone anabolic factors CCL2/MCP-1, CCL5/RANTES and IGF-1 in vitro.
Axotomy Leads to Reduced Calcium Increase and Earlier Termination of CCL2 Release in Spinal Motoneurons.
Our results showed that MIF regulates MCP-1 expression in hepatocytes of injured liver via CD74, CD44, and p38 MAPK in an autocrine manner.
these results provide novel insights into CCL2-mediated signaling mechanisms in the porcine endometrium at the maternal-fetal interface during early pregnancy
CXCL10 protein was detected in serum from pigs infected with a high virulence African swine fever virus isolate. Levels of CCL2 mRNA were increased in pigs infected with the high virulence isolate compared to a low virulence isolate.
Porcine CCL2 binding on Tuk4+SLA-II- but not on Tuk4-SLA-II+ cells was detected by using a CCL2-green fluorescence protein fusion protein.
The protective properties of flavonoids, such as EGCG, against endothelial inflammation may be regulated in part though induction of HO-1 and subsequent activator protein-1 signaling.
MCP-1 contributes to functional and structural impairment in the kidney in renal artery stenosis, mainly in the tubulointerstitial compartment
may contribute to xenograft rejection by attracting monocytes into the islets
Contrast media did not affect bone marrow cell viability/MCP-1 secretion.
Porcine vessel wall injury via balloon arthroplasty upregulates expression of CCL2 by coronary artery transmural and perivascular cells in a sequential pattern.
in the aortic arch expression of monocyte chemoattractant protein 1 (MCP-1) was upregulated, compared with the thoracic aorta
Variable gene expression (eg, matrix metalloproteinase-9, CCL2 and Lp-PLA(2) mRNAs), both in regard to the arterial bed and duration of disease, was associated with variable plaque development and progression.
myocardial infarction induced proinflammatory gene and protein expression in peripheral blood mononuclear cells of tissue factor cyclo-oxygenase-2, monocyte chemoattractant protein-1 and CRP
CCL2 plays a pivotal role in reproductive tissues and may support maternal-fetal interface to improve efficiency of pregnancy.
resence of type 2 diabetes negatively affects the work of cytokines and markers of fibrosis, as evidenced by higher levels of interleukin-1beta and monocyte chemoattractant protein-1, compared with patients without diabetes
Studied SNPs in the bovine toll-like receptor 4 (TLR4) and monocyte chemo attractant protein-1(CCL2) genes.
The LEP, IGF2 and CCL2 genes showed allelic expression imbalance in liver, kidney and pituitary glands of Polish Holstein-Friesian bulls.
immune cells and endothelial cells can interact cooperatively to increase CCL2 secretion in the corpus luteum
Data show that peripheral blood endothelial progenitor cells can increase the expressions of chemokines CCL2 and CXCL12 and promote the migration of enhanced green fluorescent protein-positive bone marrow stromal cells to bone defect site.
Data show that the serum levels of mast cell tryptase, monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) decreased significantly in Dachengqi decoction treatment group.
measurements of CCL2 and macrophages can serve as new inflammatory biomarkers to evaluate the safety of promising novel microbicides for prevention of HIV.
Expression of MCP-1 was successfully inhibited by transfecting MCP-1 siRNA expression plasmid to the carotid artery, and the progression of atherosclerosis was restricted by RNAi-mediated silencing of MCP-1 expression.
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4.
C-C motif chemokine 2
, monocyte chemoattractant protein 1
, monocyte chemoattractant protein-1
, monocyte chemotactic and activating factor
, monocyte chemotactic protein 1
, monocyte secretory protein JE
, small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je)
, small inducible cytokine subfamily A (Cys-Cys), member 2
, small-inducible cytokine A2
, platelet-derived growth factor-inducible protein JE
, small inducible cytokine A2
, immediate-early serum-responsive JE protein
, immediate-early serum-responsive protein JE
, small inducible gene JE
, acidic seminal fluid protein
, monocyte chemotactic protein 1A
, chemokine CCL2/MCP-1
, Monocyte chemoattractant protein 1
, Monocyte chemotactic protein 1
, Small-inducible cytokine A2