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A subset of well-differentiated hepatocellular carcinomas are arginase-1 negative.
The data in this study suggest that arginase I inhibition potentially represents a novel therapeutic target for the prevention and/or treatment of bronchopulmonary dysplasia-associated pulmonary hypertension.
this study shows that infiltrating macrophages expressing Arg1 are present in active allergic contact dermatitis lesions
High arginase expression is associated with glioblastoma.
Report the value of Arg-1 in distinguishing HepPar-1-positive prostatic carcinoma from hepatocellular carcinoma at metastatic sites or cases of liver metastasis from prostate carcinoma.
AEG-1 (zeige MTDH Proteine) is positively activated in the tumorigenesis and deterioration of NSCLC.
Arginase-1 expression is common (62.5%) in hepatoid adenocarcinoma and hence it is not useful in distinguishing hepatocellular carcinoma from hepatoid adenocarcinoma.
Arginase 1 was highly expressed by tumor-associated Gr1+ microglia and macrophages.
The authors report here that Candida albicans blocks nitric oxide production in human-monocyte-derived macrophages by induction of host arginase activity.
Evidence for a negative association of arginase I with job strain and positive association with job control and social support in females.
Arginase has a role in preventing angiogenesis in endothelial cells exposed to hypoxia
Ang II (zeige AGT Proteine) increases endothelial arginase activity/expression through a p38 MAPK (zeige MAPK14 Proteine)/ATF-2 (zeige ATF2 Proteine) pathway leading to reduced endothelial NO production
results indicate that arginase induction depends in part on epidermal growth factor (EGF (zeige EGF Proteine)) receptor (zeige EGFR Proteine) activity, and that EGFR (zeige EGFR Proteine) inhibitors may attenuate vascular remodeling without affecting nitric oxide release
high glucose (HG)-treated bovine coronary endothelial cells (BCECs) showed increased arginase activity and diminished NO production
Data suggest that chronic hypoxia enhances HIF-2alpha stability, which causes increased arginase expression and dysregulates normal vascular NO homeostasis.
Deletion of Arg1 in hematopoietic cells adversely affects blood leukocyte counts and increases foam cell formation. However, no effects on atherosclerosis could be demonstrated, indicating that hematopoietic Arg1 function is not a decisive factor in atherosclerotic plaque formation.
diabetes-dependent increase in renal arginase-2 (zeige ARG2 Proteine) expression also requires arginase-1 expression in macrophages
this study shows that mice lacking Arg1 in macrophages develop increased allergic contact hypersensitivity
this study shows that Ron (zeige MST1R Proteine) is expressed in a subpopulation of macrophages during chronic inflammation induced by obesity that exhibit a repair phenotype as determined by the expression of arginase 1
This study uncovers synergistic activation of Arg1 by retinoic acid and IL-4 (zeige IL4 Proteine) in M2 macrophages.
this study shows that group 2 innate lymphoid cells selectively express arginase 1 and that this is critical for their bioenergetics, proliferation and function
this study shows that c-Jun (zeige JUN Proteine) regulates the activation state of macrophages and promotes arthritis via differentially regulating cyclooxygenase-2 (zeige PTGS2 Proteine) and arginase-1 levels
deletion or TNF-mediated restriction of Arg1 unleashes the production of nitric oxide by NOS2, which is critical for pathogen control.
The immunosuppressive effect of a purified substance (ISF (zeige ATP6V0A2 Proteine)) in the culture medium of neonatal pig liver fragments was due to arginase activity that decreased arginine concentration in culture medium, not to another function of ISF (zeige ATP6V0A2 Proteine).
Results show that ischemia markedly potentiated the expression of arginase-1, and also induced the SOD2 (zeige SOD2 Proteine) in the wound tissue.
Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene.
, liver-type arginase
, type I arginase
, arginase 1
, arginase I
, arginase 1, liver
, AI type I arginase
, arginase, hepatic