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TGF-beta1 (zeige TGFB1 Proteine) and arginase-1 may play important roles in determining long-term graft survival.
These results showed that arginase controlled sFlt-1 elevation to some extent.
ARG1 gene polymorphisms and their association in individuals with essential hypertension in Pakistan has been presented.
A subset of well-differentiated hepatocellular carcinomas are arginase-1 negative.
The data in this study suggest that arginase I inhibition potentially represents a novel therapeutic target for the prevention and/or treatment of bronchopulmonary dysplasia-associated pulmonary hypertension.
this study shows that infiltrating macrophages expressing Arg1 are present in active allergic contact dermatitis lesions
High arginase expression is associated with glioblastoma.
Report the value of Arg-1 in distinguishing HepPar-1-positive prostatic carcinoma from hepatocellular carcinoma at metastatic sites or cases of liver metastasis from prostate carcinoma.
AEG-1 (zeige MTDH Proteine) is positively activated in the tumorigenesis and deterioration of NSCLC.
Arginase-1 expression is common (62.5%) in hepatoid adenocarcinoma and hence it is not useful in distinguishing hepatocellular carcinoma from hepatoid adenocarcinoma.
Activity of arginase before and at the time of parturition might be a potential marker for occurrence of metritis, especially in cows that develop retained fetal membranes.
Arginase has a role in preventing angiogenesis in endothelial cells exposed to hypoxia
Ang II (zeige AGT Proteine) increases endothelial arginase activity/expression through a p38 MAPK (zeige MAPK14 Proteine)/ATF-2 (zeige ATF2 Proteine) pathway leading to reduced endothelial NO production
results indicate that arginase induction depends in part on epidermal growth factor (EGF (zeige EGF Proteine)) receptor (zeige EGFR Proteine) activity, and that EGFR (zeige EGFR Proteine) inhibitors may attenuate vascular remodeling without affecting nitric oxide release
high glucose (HG)-treated bovine coronary endothelial cells (BCECs) showed increased arginase activity and diminished NO production
This study shows for the first time that diabetes-induced increases in arginase 1 expression promotes endothelial cell senescence through the activation of p16INK4A and p53 (zeige TP53 Proteine) signaling pathways.
findings identified a novel function of the VEGFR1 (zeige FLT1 Proteine) signaling in avoiding over-expression of Arginase 1 potentially to maintain the proper innate immune response.
Up-regulation of arginase 1 expression/activity in vascular endothelial cells has an integral role in diet-induced cardiovascular dysfunction and metabolic syndrome.
Complete ablation of Arg1 in the lung affects mRNA abundance of arginine-transporting and -metabolizing genes, and pro-inflammatory genes, but not methacholine responsiveness or accumulation of inflammatory cells.
Data suggest that Arg1 mRNA and protein expression in liver are significantly higher in obese mice (fed high-fat diet) than in control mice; hepatic Arg1 levels positively correlate with plasma Arg1 levels and negatively correlate with L-arginine (zeige GATM Proteine) bioavailability in plasma. Increased expression of hepatic Arg1 and reduced plasma L-arginine (zeige GATM Proteine) and NO(2)(-) may lead to vascular endothelial dysfunction even in early obesity.
Data suggest that chronic hypoxia enhances HIF-2alpha stability, which causes increased arginase expression and dysregulates normal vascular NO homeostasis.
Deletion of Arg1 in hematopoietic cells adversely affects blood leukocyte counts and increases foam cell formation. However, no effects on atherosclerosis could be demonstrated, indicating that hematopoietic Arg1 function is not a decisive factor in atherosclerotic plaque formation.
diabetes-dependent increase in renal arginase-2 (zeige ARG2 Proteine) expression also requires arginase-1 expression in macrophages
this study shows that mice lacking Arg1 in macrophages develop increased allergic contact hypersensitivity
this study shows that Ron (zeige MST1R Proteine) is expressed in a subpopulation of macrophages during chronic inflammation induced by obesity that exhibit a repair phenotype as determined by the expression of arginase 1
The immunosuppressive effect of a purified substance (ISF (zeige ATP6V0A2 Proteine)) in the culture medium of neonatal pig liver fragments was due to arginase activity that decreased arginine concentration in culture medium, not to another function of ISF (zeige ATP6V0A2 Proteine).
Results show that ischemia markedly potentiated the expression of arginase-1, and also induced the SOD2 (zeige SOD2 Proteine) in the wound tissue.
Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene.
, liver-type arginase
, type I arginase
, arginase 1
, arginase I
, arginase 1, liver
, AI type I arginase
, arginase, hepatic