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Liver Arginase Protein (active Mutant)

ARG1 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant >90 % (SDS-PAGE)
Produktnummer ABIN6253489
  • Target Alle Liver Arginase (ARG1) Proteine anzeigen
    Liver Arginase (ARG1) (Arginase, Liver (ARG1))
    Protein-Typ
    Recombinant
    Proteineigenschaft
    active Mutant
    Spezies
    • 11
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Quelle
    • 6
    • 5
    • 5
    • 1
    • 1
    • 1
    Escherichia coli (E. coli)
    Verwendungszweck
    Arginase I (human) (rec.) (highly active)
    Spezifität
    Full length human arginase I.
    Produktmerkmale
    Protein. Full length human arginase I. Source: E. coli. Liquid. In 10  mM TRIS-HCl,  pH 7.5, containing 1  mM beta-mercaptoethanol, 1  mM MnCl2 and 50 % glycerol. Purity: >90 % (SDS-PAGE). Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Arginase is involved in the nitric oxide (NO) pathway and immune cell arginine metabolism. It is fundamentally involved in cancer, inflammation, infections, fibrotic diseases, neurobiology, pregnancy and immune regulation in general.
    Reinheit
    >90 % (SDS-PAGE)
    Biological Activity Comment
    1.6 ±0.2U/μg protein. One unit is defined as the amount of enzyme that converts 1μmol of L-arginine to L-ornithine and urea per min. at 37°C, pH 9.5 (according to protocol from R.T. Schimke, et al.; J. Biol. Chem. 238, 1012 (1963)).
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  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. In 10  mM TRIS-HCl,  pH 7.5, containing 1  mM beta-mercaptoethanol, 1  mM MnCl2 and 50 % glycerol.
    Handhabung
    Avoid freeze/thaw cycles.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung

    Short Term Storage: -20°C

    Long Term Storage: -80°C

    Use & Stability: Stable for at least 1 year after receipt when stored at -80°C.

  • Target
    Liver Arginase (ARG1) (Arginase, Liver (ARG1))
    Andere Bezeichnung
    Arginase I (ARG1 Produkte)
    Synonyme
    SI:zC146F4.4 (novel protein with NUDIX domain) Protein, si:ch211-146f4.3 Protein, argi1 Protein, AI Protein, AI256583 Protein, Arg-1 Protein, PGIF Protein, arginase 1 Protein, arginase Protein, Arginase-1 Protein, arginase, liver Protein, L-arginase Protein, arg1 Protein, PGTG_16455 Protein, argi1 Protein, ARG1 Protein, Arg1 Protein
    Hintergrund

    Alternate Names/Synonyms: EC 3.5.3.1, ARG1, Arginase 1, Type I Arginase, Liver-type Arginase, L-Arginase

    Product Description: Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Arginase is involved in the nitric oxide (NO) pathway and immune cell arginine metabolism. It is fundamentally involved in cancer, inflammation, infections, fibrotic diseases, neurobiology, pregnancy and immune regulation in general.

    UniProt
    P05089
    Pathways
    Cellular Response to Molecule of Bacterial Origin
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